Navigation Links
Boffins Develop New Technique to Hunt Illness-causing Mutants in Non-gene DNA

University of Utah geneticists say that they have developed a faster, less expensive technique to hunt illness-causing mutants in large, non-gene stretches of DNA. The development of the new technique is important because diseases can result not only from mutant genes, but also from mutations of other DNA that controls genes.

"Diseases are known to occur as a consequence of deleting non-gene DNA sequences, and this new method allows us to evaluate what these sequences do," Nature magazine quoted Mario Capecchi, distinguished professor and co-chair of human genetics at the University of Utah, as saying.

He says that the new method attains significance as it "makes it practical to do this for a vast amount of the total genome." Sen Wu, a postdoctoral fellow in human genetics at the University of Utah, says human diseases were studied in mice, "we want to know the function of every piece of DNA in the mouse genome."

"The best way to know the function of the genetic blueprint is by removing part of the DNA and seeing what goes wrong. We have found a way to do this job on a large scale that is simple and practical," added the researcher.

According to researchers, the finding of a way to delete or duplicate moderately long to very long pieces of DNA, and make those mutations happen much more frequently than other methods can, makes it easier to determine what defects or diseases arise due to such mutations, and thus what the DNA does normally.

They devised a much more efficient method for mixing and recombining pieces of two chromosomes, making it easier to breed mice with human cancers. Such mice are needed to develop new treatments. "We know how to knock out genes, and that technology is very good at changing any given gene in a designed manner. The negative side is, it takes work and money to do that," Capecchi says.

The new method is "a cheaper way of knocking out a gene as well as reg ulatory sequences," he adds. He, however, admits that the savings are not proportionate because more mutant mice must be bred to obtain desired mutants.


'"/>




Related medicine news :

1. Fizzy Logic For A Perfect Drink: Courtesy Boffins
2. Boffins Identify Fifth Gene Behind Joubert Syndrome
3. Boffins Find Link Between Common Sleep Disorder and Hypertension
4. Boffins Identify Molecule That Might Treat Food Allergy
5. Boffins a Step Closer to Solving Puzzle of Lou Gehrigs Disease
6. Boffins Identify Gene That Helps Regulates Body Weight
7. Boffins Link Atkins Diet With Bowel Cancer
8. Developmental, neurologic problems common in extremely preterm infants
9. Development of AIDS vaccine -- Chiron Corp in talks with four Indian cos
10. Risk Of Developing Arthritis
11. Developing HIV fighter
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... , ... TherapySites, the leading website and online ... Counseling Association. This new relationship allows TherapySites to continue to extend their ... benefits and promotional offers. , "TCA is extremely excited about this new partnership, ...
(Date:6/26/2016)... ... 27, 2016 , ... Quality metrics are proliferating in cancer care, and are ... the eye of the beholder, according to experts who offered insights and commentary in ... Managed Care. For the full issue, click here . , For the American ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified ... be personalized through a fitness app. The fitness app plans to fix the two major ... only offer a one size fits all type program , They don’t eliminate ...
(Date:6/25/2016)... FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial ... Plant City Observer , brings up a new, often overlooked aspect of head lice: the ... closing for fumigation is not a common occurrence, but a necessary one in the event ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as ... City area —Johnson is one of the first doctors to perform the treatment. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Research and Markets has announced the ... Tests" report to their offering. ... The World Market for Companion Diagnostics covers the ... analysis in the report includes the following: ... Kits) by Region (N. America, EU, ROW), 2015-2020 , ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced ... as its e-clinical software solution of choice.  This ... best possible value to their clients by offering ... The preferred relationship establishes nowEDC as the EDC ... for MedSource,s full-service clients.  "nowEDC has long been ...
(Date:6/23/2016)... 23, 2016 Roche (SIX: RO, ROG; OTCQX: ... its Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated ... shock. With this clearance, Roche is the first IVD ... solution for sepsis risk assessment and management. ... and PCT levels in blood can aid clinicians in ...
Breaking Medicine Technology: