Navigation Links
Boffins Develop New Technique to Hunt Illness-causing Mutants in Non-gene DNA

University of Utah geneticists say that they have developed a faster, less expensive technique to hunt illness-causing mutants in large, non-gene stretches of DNA. The development of the new technique is important because diseases can result not only from mutant genes, but also from mutations of other DNA that controls genes.

"Diseases are known to occur as a consequence of deleting non-gene DNA sequences, and this new method allows us to evaluate what these sequences do," Nature magazine quoted Mario Capecchi, distinguished professor and co-chair of human genetics at the University of Utah, as saying.

He says that the new method attains significance as it "makes it practical to do this for a vast amount of the total genome." Sen Wu, a postdoctoral fellow in human genetics at the University of Utah, says human diseases were studied in mice, "we want to know the function of every piece of DNA in the mouse genome."

"The best way to know the function of the genetic blueprint is by removing part of the DNA and seeing what goes wrong. We have found a way to do this job on a large scale that is simple and practical," added the researcher.

According to researchers, the finding of a way to delete or duplicate moderately long to very long pieces of DNA, and make those mutations happen much more frequently than other methods can, makes it easier to determine what defects or diseases arise due to such mutations, and thus what the DNA does normally.

They devised a much more efficient method for mixing and recombining pieces of two chromosomes, making it easier to breed mice with human cancers. Such mice are needed to develop new treatments. "We know how to knock out genes, and that technology is very good at changing any given gene in a designed manner. The negative side is, it takes work and money to do that," Capecchi says.

The new method is "a cheaper way of knocking out a gene as well as reg ulatory sequences," he adds. He, however, admits that the savings are not proportionate because more mutant mice must be bred to obtain desired mutants.


'"/>




Related medicine news :

1. Fizzy Logic For A Perfect Drink: Courtesy Boffins
2. Boffins Identify Fifth Gene Behind Joubert Syndrome
3. Boffins Find Link Between Common Sleep Disorder and Hypertension
4. Boffins Identify Molecule That Might Treat Food Allergy
5. Boffins a Step Closer to Solving Puzzle of Lou Gehrigs Disease
6. Boffins Identify Gene That Helps Regulates Body Weight
7. Boffins Link Atkins Diet With Bowel Cancer
8. Developmental, neurologic problems common in extremely preterm infants
9. Development of AIDS vaccine -- Chiron Corp in talks with four Indian cos
10. Risk Of Developing Arthritis
11. Developing HIV fighter
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, ... Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility ... home to some of the world’s leading providers of cereal and other breakfast foods. ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many ... been diagnosed with endometriosis. These women need a treatment plan to not only ... approach that can help for preservation of fertility and ultimately achieving a pregnancy. ...
(Date:6/25/2016)... Viejo, California (PRWEB) , ... June 25, 2016 , ... ... to fit their specific project," said Christina Austin - CEO of Pixel Film Studios. ... fully customizable and all within Final Cut Pro X . Simply select a ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
(Date:6/24/2016)... Michigan (PRWEB) , ... June 24, 2016 , ... June ... about the dangers associated with chronic pain and the benefits of holistic treatments, ... individuals who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has announced ... Forecast to 2022" report to their offering. ... the patients with kidney failure, it replaces the function of ... patient,s blood and thus the treatment helps to keep the ... balance. Increasing number of ESRD patients & ...
(Date:6/23/2016)... June 23, 2016 Roche (SIX: RO, ROG; ... for its Elecsys BRAHMS PCT (procalcitonin) assay as a ... septic shock. With this clearance, Roche is the first ... integrated solution for sepsis risk assessment and management. ... infection and PCT levels in blood can aid clinicians ...
(Date:6/23/2016)... Bracket , a leading clinical trial technology ... outcomes platform, Bracket eCOA (SM) 6.0, at the 52 ... 30, 2016 in Philadelphia , Pennsylvania.  A ... product of its kind to fully integrate with RTSM, will ... 6.0 is a flexible platform for electronic clinical outcomes assessments ...
Breaking Medicine Technology: