Navigation Links
Boffins Develop New Technique to Hunt Illness-causing Mutants in Non-gene DNA

University of Utah geneticists say that they have developed a faster, less expensive technique to hunt illness-causing mutants in large, non-gene stretches of DNA. The development of the new technique is important because diseases can result not only from mutant genes, but also from mutations of other DNA that controls genes.

"Diseases are known to occur as a consequence of deleting non-gene DNA sequences, and this new method allows us to evaluate what these sequences do," Nature magazine quoted Mario Capecchi, distinguished professor and co-chair of human genetics at the University of Utah, as saying.

He says that the new method attains significance as it "makes it practical to do this for a vast amount of the total genome." Sen Wu, a postdoctoral fellow in human genetics at the University of Utah, says human diseases were studied in mice, "we want to know the function of every piece of DNA in the mouse genome."

"The best way to know the function of the genetic blueprint is by removing part of the DNA and seeing what goes wrong. We have found a way to do this job on a large scale that is simple and practical," added the researcher.

According to researchers, the finding of a way to delete or duplicate moderately long to very long pieces of DNA, and make those mutations happen much more frequently than other methods can, makes it easier to determine what defects or diseases arise due to such mutations, and thus what the DNA does normally.

They devised a much more efficient method for mixing and recombining pieces of two chromosomes, making it easier to breed mice with human cancers. Such mice are needed to develop new treatments. "We know how to knock out genes, and that technology is very good at changing any given gene in a designed manner. The negative side is, it takes work and money to do that," Capecchi says.

The new method is "a cheaper way of knocking out a gene as well as reg ulatory sequences," he adds. He, however, admits that the savings are not proportionate because more mutant mice must be bred to obtain desired mutants.


Related medicine news :

1. Fizzy Logic For A Perfect Drink: Courtesy Boffins
2. Boffins Identify Fifth Gene Behind Joubert Syndrome
3. Boffins Find Link Between Common Sleep Disorder and Hypertension
4. Boffins Identify Molecule That Might Treat Food Allergy
5. Boffins a Step Closer to Solving Puzzle of Lou Gehrigs Disease
6. Boffins Identify Gene That Helps Regulates Body Weight
7. Boffins Link Atkins Diet With Bowel Cancer
8. Developmental, neurologic problems common in extremely preterm infants
9. Development of AIDS vaccine -- Chiron Corp in talks with four Indian cos
10. Risk Of Developing Arthritis
11. Developing HIV fighter
Post Your Comments:

(Date:11/27/2015)... ... 27, 2015 , ... CBD College is proud to announce that ... awarded accreditation to its Diagnostic Medical Sonography program. CBD College is honored to join ... twelve colleges and universities in the state of California make the cut. CBD College ...
(Date:11/27/2015)... ... November 27, 2015 , ... Indosoft Inc., ... the incorporation of Asterisk 11 LTS (Long Term Support) into its Q-Suite 5.10 ... brings Q-Suite 5.10 up-to-date with a version of Asterisk that will receive not ...
(Date:11/26/2015)... , ... November 26, 2015 , ... ... Express Travel Representative. As a franchise owner, Somu now offers travelers, value and ... destination wedding packages, private cruise sales, as well as, cabin upgrades and special ...
(Date:11/26/2015)... ... November 26, 2015 , ... WorldCare ... participated in the 61st annual Employee Benefits Conference. The Employee Benefits Conference was ... November 8th through Wednesday, November 11th, 2015. The conference was held at the ...
(Date:11/25/2015)... ... November 25, 2015 , ... Additional breast cancers ... on mammography, according to a study published online in the journal Radiology. Researchers ... mammography may necessitate a change in treatment. , Breast MRI is the most ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... UTRECHT, the Netherlands , November 26, 2015 /PRNewswire/ ...   A new combination approach blends immunotherapy ... --> A new combination approach blends immunotherapy with ... A new combination approach blends immunotherapy with ... the Netherlands has found that immunotherapy ...
(Date:11/26/2015)... , November 26, 2015 3D bioprinting ... 2022, according to a new report by Grand View Research ... Disease (CKD) which demands kidney transplantation is expected to boost ... effective substitute for organ transplantation. --> 3D bioprinting ... 2022, according to a new report by Grand View Research ...
(Date:11/26/2015)... ) has ... Future Horizons and Growth Strategies in the ... Shares, Country Segment Forecasts, Competitive Intelligence, Emerging ... --> ) has announced the ... and Growth Strategies in the German Drugs ...
Breaking Medicine Technology: