Navigation Links
Body's Defence Mechanism Against Viral Disease Discovered

Fox Chase Cancer Center researchers say that they have discovered the defence mechanism whereby "memory" T cells protect the body from viral diseases. Published in the online edition of the Proceedings of the National Academy of Science, their study shows that lymph nodes are not just organs where immune cells reside and proliferate, but also are the sites where a major fight against the spread of an invading virus occurs.

Lead author of the study, Dr. Luis J. Sigal, says while the role of antibodies in protection has been known for a long time, the ability of memory cells (CD8T) in preventing viral diseases has been debated. He claims that his team's work provides the basis whereby memory T cells prevent viral diseases.

The body becomes "immune" from recurrence of the same disease when the immune system produces cells called lymphocytes that specifically attack and eliminate the virus at the time of infection. Most of the lymphocytes die after the infection subsides, but some remain in the body as "memory lymphocytes" and protect the body from recurrence of the disease.

Earlier, scientists used to think that in order to protect from disease, the memory T cells need to multiply in the lymph nodes, and then migrate through the blood to kill infected cells at the site where the virus entered the body-most commonly the skin, the lungs or the gut.

But to the contrary, the researcher have now shown that memory T cells protect from viral disease without the need to migrate from the lymph nodes to the site of viral entry. "It was very difficult to imagine how the memory T cells could win this race," said Sigal, because process of lymphocyte multiplication and migration may take several days while viruses multiply and spread quicker.

The researchers say that their experiments have shown the ability of memory T cells to rapidly multiply and kill target cells inside the lymph node.

"In fact we fou nd that memory CD8 T cells already killed target cells in the lymph node and decreased viral spread to the liver and spleen when the virus just barely started to multiply," Sigal said.

The researchers conclude that memory CD8 T cells do not prevent infection, but prevent disease partly because they curb the spread of the virus from the lymph node to vital organs at very early stages of the infection.

"It's like having a security check point. Also, many cancers, like viruses, must pass through lymph nodes to metastasise, so this research may help develop vaccines that prevent tumour metastases," said Sigal.


'"/>




Related medicine news :

1. New Treatment For Skin Cancer Using Bodys own Immune System
2. Now, Store Your Bodys Immune System for Future Use Against Deadly Diseases
3. Defence against free radicals
4. Countries Defenceless Against Bird Flu
5. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
6. New Gene Silencing Mechanism To Prevent Cancer
7. Molecular Mechanism Of HIV Infecting The Healthy Cells Discovered.
8. Self-defense Mechanism of food borne bugs found
9. Specific Immune Mechanism against DNA viruses
10. A New Focus For The Mechanism Of Nerve Growth
11. Mechanism of Stem Cell Regulation Identified
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... ... PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with clinical associate professor ... prevention of cardiovascular diseases during the 15th Annual Women’s Health Conference. The ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , ... mock evacuation of the facility as part of a disaster drill on October 3rd. ... EMS and Shelton City Emergency Manager, as well as the Connecticut Long Term ...
(Date:10/13/2017)... ... ... The Visiting Nurse Association (VNA) of Somerset Hills is proud to host ... items from across the nation, this holiday-themed event will raise funds and awareness for ... The boutique will be open Saturday, November 4 (10:00 a.m. – 5:00 p.m.) ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids this ... by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited about ... ages; it is a non-competitive, non-timed event, which is all about having fun and ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob Lowe, ... in a new episode of "Success Files," which is an award-winning educational program ... investigates each subject in-depth with passion and integrity. , Sciatica occurs when the ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... ROCKVILLE, Md. , Sept. 22, 2017  As ... by Republican Senators Bill Cassidy (R-LA) and ... Kalorama Information notes that the medical device industry is ... the medical device tax, the 2.3% excise tax on ... Act.  But they also want covered patients, increased visits ...
(Date:9/19/2017)... Mich. , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company ... destruction of targeted tissues, announced three leadership team developments today:   ... PhD ... ... Veteran medical device executive Josh ...
(Date:9/18/2017)... KALAMAZOO, Mich. , Sept. 18, 2017 ... , and OptiMed Specialty Pharmacy of Kalamazoo, ... offer a strategic hub service that expedites and streamlines ... personal spirometer, Spiro PD 2.0, and wellness management services.  ... is a medical device used to measure lung function ...
Breaking Medicine Technology: