Navigation Links
Blood test may aid foretell Alzheimer's

According to study in University of Texas, a novel blood test can detect plaque buildup in mice brains, suggesting a possible new way to predict who might get Alzheimer's disease.Researchers at the School of Medicine in St. Louis said it is unclear whether a similar blood test would work in people, but the findings in the animal studies appeared promising.//

Plaque buildup ruins brain cells and is the cause of Alzheimer's. Some people have a genetic propensity to develop this plaque later in life. The St. Louis team examined 40 mice carrying a genetic mutation to develop buildup up amyloid plaque. Two types of this amyloid protein were measured in the mice's blood. Animals then were injected with an antibody -- an immune system substance that fights infection -- called m266 -- which draws amyloid protein from the brain into the blood.

Within five minutes of the m266 injection, amyloid levels increased dramatically in the blood, indicating how much amyloid protein had built up in the mouse's brain. "That's like unbelievably fast," researcher Dr. David M. Holtzman told United Press International. "We thought if you saw anything it would take days."

The mice's brains were studied 24 hours after injection to affirm whether the levels detected in the blood had accurately reflected how much amyloid protein had built up in the brain tissue. The m266 injection appeared give an accurate picture.

"If this worked the same way in humans, it has the potential to be a predictor on who might develop Alzheimer's later," Holtzman added. M266 is a mouse antibody, Holtzman cautioned, so whether a similar human antibody exists to draw this plaque from the brain into the blood in people remains untested.

It is estimated 4 million Americans have Alzheimer's disease and that figure is expected to double in coming decades as more people live longer, though Holtzman said, "I think that's a big under-estimate," because it doesn't includ e folks with mild dementia.

Alzheimer's is a difficult disease to detect and doctors usually are not able to diagnose it or treat symptoms until the condition has progressed into more advanced stages. There is no cure for Alzheimer's but scientists are interested in an early screening test because earlier detection could mean starting treatment before symptoms -- such as forgetfulness, disorientation and dementia -- become unbearable.

"There's a tremendous ethical question for diagnosing (early) a disease for which this is no cure," James L. Olds, a professor of neuroscience at George Mason University in Fairfax, Va., and director of the Krasnow Institute, cautioned in an interview with UPI.

He said since there is no cure and limited treatment, telling a person they have Alzheimer's when there is no cure means that person must knowingly live with it for a longer period of time -- while they still have most of their cognitive capabilities -- rather than being told when the disease has progressed to the point they are not able to fully comprehend.

That does not mean, however, a blood test would not be useful in understanding what is taking place in the brain, he added. "If we assume what's happening in the blood is happening in the brain," he said, "that's a big red flag that things aren't going well."


'"/>




Related medicine news :

1. Recommendations for Treatment of Blood Pressue
2. Blood Cells Capable of Regenerating Liver
3. Blood clots likely in long travel
4. Hemochromatosis Patients Blood is Safe
5. Blood transfusions beneficial after heart attacks
6. Blood Pressure Drug may slow wasting in burn victims
7. Levels Of Blood Proteins May Help Heart Disease Care
8. Blood test may identify ovarian cancer
9. A Blood test for suicide risk?
10. Blood Pressure Drugs maintain muscle strength
11. Blood test diagnoses heart failure in short time
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... CO (PRWEB) , ... March 23, 2017 , ... ... serving the families and businesses of the greater Fort Collins area, has unveiled ... in their ongoing community involvement program. Donations to this worthy cause may now ...
(Date:3/23/2017)... ... ... After raising more than $1.135 million ($1,479,231 AUD) from nearly 20,000 backers ... crowdfunding history, has established a U.S. Headquarters in New York City, FaceCradle USA, LLC, ... excited to be operating on U.S. shores, where most of our initial crowdfunding backers ...
(Date:3/23/2017)... ... ... Hospital and Health System Executive Speakers including: , , Chief Executive ... United States of America: George W. Bush , Boxing Legend, Successful Entrepreneur and ... , JD, Chairperson, McGuireWoods LLP: Amber McGraw Walsh , Senior Vice ...
(Date:3/23/2017)... ... 23, 2017 , ... Sharon Kleyne, host of the nationally syndicated radio program, ... VoiceAmerica, recently talked on her program about how she is looking forward to World ... of an important distinction. World Water Day, Kleyne pointed out, is an occasion for ...
(Date:3/23/2017)... Boca Raton, FL (PRWEB) , ... March 23, ... ... range of dietary supplements that help improve all aspects of people’s health and ... popular website for nutritional products. , Natural Subsistence develops nutritional supplements that ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... India , March 23, 2017 ... growing ageing population, increasing diabetic population, accelerating economic growth and ... of this industry are higher life expectancy of ESRD patients, ... in emerging markets. However, the expansion of the market is ... ...
(Date:3/23/2017)... and INDIANAPOLIS , March ... LLY ) and the William Sansum Diabetes Center ... of Latino people affected by diabetes through enhanced research, ... of diabetes and cardiovascular disease bears a disproportionate weight ... ," said David Kerr , M.D., FRCPE, ...
(Date:3/23/2017)... , March 23, 2017   BioSpace , ... resource, has partnered with Indiana Biosciences Research Institute ... organizations and educational institutions to bring the state,s ... first-ever BioIndiana Hotbed map, an artistic representation of the ... was presented to Vice President Mike Pence , ...
Breaking Medicine Technology: