Navigation Links
Blood from Bird Flu Survivors Provides Breakthrough in Treatment of H5N1

US researchers report that antibodies extracted from the blood of bird flu survivors have helped cure mice infected with the dreaded H5N1 bird flu virus.

Scientists have long suspected that culling immune-system molecules from survivors could provide a new therapy for the hard-to-treat H5N1 flu strain.

If the research pans out, it could be possible to stockpile these antibodies, the immune system's search-and-destroy force, as an additional way to treat or even prevent H5N1 in case the worrisome flu strain ever mutates to spark a worldwide epidemic.

The research started when four Vietnamese adults who survived bouts of H5N1 in 2004 agreed to donate blood to the Hospital for Tropical Diseases in Ho Chi Minh City.

At Switzerland's Institute for Research in Biomedicine, Dr. Antonio Lanzavecchia created a way to cull antibody-producing cells from the blood and keep them churning out the molecules in laboratory dishes.

In the U.S., the National Institute of Health's Dr. Kanta Subbarao tested thousands of those antibodies to tease out the handful able to kill H5N1. They were purified to better target the virus.

Then came the real tests: Subbarao's lab infected mice with H5N1. Some were given the antibodies before they were exposed, others after they already were infected; still others were given antibodies that target different diseases, not influenza.

Mice given the non-H5N1 antibodies died. The H5N1-targeting antibodies protected mice, both when they were administered as a vaccine-like preventive or after infection. Importantly, they worked against both the same 2004 strain that the people had survived and against a different H5N1 strain that circulated in 2005.

The work is reported Monday in the online journal PLoS-Medicine.

"Obviously we're interested and excited about this potential," said Dr. Anthony Fauci, infectious disease chief at the National Institutes of Health .

This approach is called "passive immunotherapy," and more crude forms of the approach have long been used to protect against certain viruses. Before hepatitis A vaccines, for example, antibody-containing shots were common for tourists heading to developing countries.

And during the 1918 flu pandemic, the worst in history, doctors sometimes transfused blood directly from survivors to the newly sick, sometimes with good results.

The mouse study is "a very lovely, elegant proof of principle," said Dr. William Schaffner, a flu expert at Vanderbilt University.

More work is needed before trying these purified antibodies in people. It's standard to test flu vaccines and treatments in ferrets, who respond to influenza more like people do. Then the antibodies would need testing in healthy people, to see if they're safe.

If so, they might be tried as a treatment for people still falling ill with H5N1 in parts of Asia. The only treatment now is the drug Tamiflu, which doesn't always save them.


'"/>




Related medicine news :

1. Recommendations for Treatment of Blood Pressue
2. Blood Cells Capable of Regenerating Liver
3. Blood clots likely in long travel
4. Hemochromatosis Patients Blood is Safe
5. Blood transfusions beneficial after heart attacks
6. Blood Pressure Drug may slow wasting in burn victims
7. Levels Of Blood Proteins May Help Heart Disease Care
8. Blood test may identify ovarian cancer
9. A Blood test for suicide risk?
10. Blood Pressure Drugs maintain muscle strength
11. Blood test diagnoses heart failure in short time
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/22/2017)... ... 22, 2017 , ... The National Academy of Certified Care ... April 2017 testing period. NACCM, a nonprofit organization, has provided the premier certification ... is periodically re-calibrated to ensure that newly certified professionals are prepared to work ...
(Date:2/22/2017)... ... February 22, 2017 , ... Giving patients with diabetes ... emergency room, fewer hospital admissions, and better blood pressure and glycemic control, a ... The study can be found here . , The study comes as ...
(Date:2/22/2017)... ... February 22, 2017 , ... In a 2012 survey, over ... not filling a prescription because they could not afford to pay for it. ... were 30-60%*. At the same time, hospitals, pharmacies, manufacturers and nursing ...
(Date:2/22/2017)... CA (PRWEB) , ... February 22, 2017 , ... Doctors ... recent addition of esteemed ophthalmologist, Dr. Steven H. Rauchman, practicing at North Valley ... in auto accidents, product liability, premise liability and other personal injury cases. These ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... newest advanced absorption cannabidiol (CBD) serum, “NANOCALM 300” Microemulsified Hemp Extract. This ... instant absorption from the mouth into the bloodstream. Far outpacing the ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... Research and Markets has announced the addition of the ... report to their offering. ... The Global Endoscopy Market is poised to grow ... reach approximately $47.6 billion by 2025. This industry ... segments on global as well as regional levels presented in the ...
(Date:2/23/2017)... Ga., Feb. 23, 2017  MiMedx Group, Inc. (NASDAQ: ... tissue and patent-protected processes to develop and market advanced ... Spine, Sports Medicine, Ophthalmic, and Dental sectors of healthcare, ... and full year ended December 31, 2016. ... Revenue is a 31% increase over full year 2015 ...
(Date:2/23/2017)... Feb. 23, 2017   SeraCare Life Sciences ... in vitro diagnostics manufacturers and clinical laboratories, is ... Implementation of NGS-Based Tests" to be hosted by ... at 11am Eastern Standard Time (US). ... the need for improved performance and global standardization ...
Breaking Medicine Technology: