Navigation Links
Blocking Glucocorticoid Prevents Stress-Induced Skin Abnormalities

Inhibiting glucocorticoid, a type of steroid, can prevent skin abnormalities induced by psychological stress, according to a new study from the December //issue of the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. The new study also shows how psychological stress induces skin abnormalities that could initiate or worsen skin disorders such as psoriasis and atopic dermatitis.

Previous research has shown that psychological stress increases glucocorticoid production. In addition, it is well recognized that psychological stress adversely affects many skin disorders, including psoriasis and atopic dermatitis.

“In this study, we showed that the increase in glucocorticoids induced by psychological stress induces abnormalities in skin structure and function, which could exacerbate skin diseases,” Feingold explained. This provides a link for understanding how psychological stress can adversely affect skin disorders. Blocking the production or action of glucocorticoids prevented the skin abnormalities induced by psychological stress.

Skin protects

The skin is the body’s largest organ and plays a crucial role in providing a barrier between the environment and the internal organs. It protects us from harmful microorganisms, ultraviolet light, toxic chemicals, and more. However, its most important function is providing a permeability barrier that prevents us from drying out. We are approximately 65 percent water and we are able to survive and function in dry environments because the skin forms a permeability barrier that prevents the loss of water.

The permeability barrier is located in the outermost layer of the epidermis, the stratum corneum. The stratum corneum is composed of dead cells surrounded by lipid membranes which mediate the permeability barrier. The stratum corneum layer continuously sloughs off, and therefore must be regenerated. The epidermal cells in the lower epi dermis are continuously proliferating to provide new cells, which then differentiate, and ultimately die, to form the stratum corneum.

Previous studies have shown that psychological stress disturbs this elegantly balanced system by decreasing epidermal cell proliferation and inhibiting differentiation. Additionally, permeability barrier function is impaired. The researchers hypothesized that the increase in glucocorticoids induced by psychological stress would cause these adverse effects on skin function.

Study with hairless mice

They tested their hypothesis by subjecting hairless mice to stress while either blocking the production of glucocorticoids or preventing them from acting on the body. The stress was created by placing the mice in small cages in constant light with a radio playing for 48 hours.

Before placing the mice in the stressful situation, the researchers treated one group of mice with RU 486, a substance that blocks the action of glucocorticoids.

A second group of mice received antalarmin, which blocks glucocorticoid production. A third group was subjected to the stress but received neither antalarmin nor RU 486. The fourth group, the control group, remained unstressed in ordinary cages and without the continuous light and sound to which the other groups were exposed.

Results confirm hypothesis

The stressed mice that received RU 486 and antalarmin showed significantly better skin function compared to the stressed mice that did not receive either treatment. The treated mice showed significantly better:

? proliferation
? differentiation
? permeability barrier function
? stratum corneum integrity
The experiment demonstrated the important role that glucocorticoids play in inducing the skin abnormalities brought on by psychological stress. While the researchers hope the study will lead to a way to treat people who suffer these s kin conditions, there is still a long way to go: First, the research was done with mice, not people. Second, there may be serious side effects of modulating glucocorticoid activity. Glucocorticoids are essential hormones that play many important roles. Blocking the action of glucocorticoids could have negative outcomes that are much worse than exacerbations in the skin disorders.

The research team is now looking at the effect of psychological stress on the skin’s production of antimicrobial peptides, which play a role in defense against infection. They hypothesize that psychological stress might also reduce the ability of the skin to protect from infections.

Source-Newswise
RM
'"/>




Related medicine news :

1. Blocking Pain Found To Slow Down The Healing Process
2. Improving The Survival Of Lung Cancer Patients By Blocking The Effects Of Estrogen
3. Protein Fragments Blocking Cures Alzheimers Disease
4. Multiple Sclerosis Can Be Treated By Blocking Fat Hormone
5. Ventilation Systems Not Effective in Blocking Tobacco Smoke
6. Study Says - Blocking aP2 Protein Prevents Airway Diseases
7. Sunscreen Blocking UVA Radiation Receives Federal Approval
8. New Cancer-Blocking Algae Found
9. Glucocorticoid in ‘bad Light’ During Fertility Treatmet
10. Harmful Effects Of Glucocorticoids On Newborns Owing To Prenatal Exposure
11. Tea Prevents Skin Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
(Date:6/24/2016)... ... 24, 2016 , ... Those who have experienced traumatic events may suffer from ... avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid this ... coping following a traumatic event. , Trauma sufferers tend to feel a range of ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... is proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon ... beautiful women in the world, and the most handsome men, look naturally attractive. ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... June 26, 2016 Story ... operating models within the health care industry is causing ... efficiency , Deloitte offers a suite of solutions ... issues impacting efficient cost optimization: labor resource analysis, revenue ... services facilitate better outcomes and better economics ...
(Date:6/24/2016)... 24, 2016 ... the addition of the " Global Markets for ... This report focuses on ... updated review, including its applications in various applications. The ... which includes three main industries: pharmaceutical and biotechnology, food ...
(Date:6/24/2016)... 24, 2016 Research and Markets has ... Companion Diagnostic Tests" report to their offering. ... Diagnostics The World Market for Companion Diagnostics ... diagnostics. Market analysis in the report includes the following: ... Vitro Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
Breaking Medicine Technology: