Navigation Links
'Blimp1' Gene Linked To Oily Skin

New research in mice has found that though they do not develop zits, the do have oily skin. Rockefeller University researchers were able to differentiate the cells// in the sebaceous glands that are responsible for the oily skin. The research examines how a sebaceous gland is formed.

In new research, published in the August 11 issue of Cell, Elaine Fuchs, a Howard Hughes Medical Institute investigator at Rockefeller University, settles this argument, showing that at the site where the sebaceous gland adjoins the hair follicle, a unique population of cells exists whose sole job is to make, and maintain, the sebaceous gland.

"We were exploring the expression of a transcription factor called Blimp1, which had surfaced in a genetic screen that we had conducted." explains Fuchs, who is the Rebecca C. Lancefield Professor and head of the Laboratory of Mammalian Cell Biology and Development at Rockefeller. "We were surprised to find that Blimp1 was expressed in a small population of cells within the sebaceous gland. We knew these cells were skin keratinocytes but no one had ever described their existence and therefore, we had no clues about their relationship to the gland."

Valerie Horsley, a postdoc in the Fuchs lab and first author of the paper, had been interested in Blimp1’s role in hair follicle development, and had engineered mice that were missing the Blimp1 gene in their skin. "When the mice were born, they formed normal hair follicles, which was quite disappointing," says Horsley. "But when they were around one month of age I noticed that the mice started getting very oily skin."

The sebaceous glands in mice missing Blimp1 were much larger than in normal skin. This happens in another genetically altered mouse, one overexpessing the c-myc gene, which has been implicated in many different kinds of cancers. Horsley found that Blimp1 usually acts to repress c-myc expression, and in mice without Blimp1 c-myc expression wa s increased, causing the sebaceous gland to contain cells that divide more frequently. When Horsley tagged the Blimp1 positive cells and tracked them, she found that the daughters of the Blimp1 cells contribute to the entire gland. Also, when grown outside in culture, the cells that make Blimp1 can divide and self-renew, as well as make the cell types important for generating the oils of the sebaceous gland.

"The data show clearly that these cells are the progenitors for the entire sebaceous gland," says Horsley. "And Blimp1 is somehow controlling this progenitor population, regulating how many cells are allowed into the gland. This is the first molecular characterization of these cells."

"This study has implications for understanding sebaceous gland disorders ranging from acne to sebaceous cell cancers," says Fuchs. "And it not only gives us a handle on these novel resident stem cells, but also clues to how stem cells can control the balance of proliferation and differentiation in tissues."

Source: Eurekalert
'"/>




Related medicine news :

1. Low Cholesterol Linked to Severe Depression and Violent Behavior in Men
2. Cough Syrup Ingredient Linked to Stroke
3. Irregular Periods Linked to Diabetes
4. Hormones Linked To Migraines
5. Triglycerides Linked To Stroke Risk
6. Smoking Linked To Low Infant Birth Weight
7. Nausea Linked To Anxiety And Depression
8. Painkiller Linked to Deaths
9. High Levels of Protein Linked to Brain Shrinkage
10. Snoring Linked To Headaches
11. Hormone Therapy Linked to Dementia
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/23/2017)... ... February 23, 2017 , ... Rosica Communications, ... relations, content marketing, social media management, corporate communications, SEO and cause marketing, is ... and in nearby New Hampshire, Massachusetts and Canada, Rosica will focus on expanding ...
(Date:2/23/2017)... ... February 23, 2017 , ... ERT, a global data ... that Premier Research, a leading clinical development service provider, has selected ERT’s Trial ... complex, due in part to an array of circumstances including the use of ...
(Date:2/23/2017)... , ... February 23, 2017 , ... CALNOC, the nation’s ... FACPE, will keynote their upcoming conference – Empowerment, Value and Collaboration – in Seattle, ... and CEO of the Virginia Mason Health System in Seattle since 2000. In addition ...
(Date:2/23/2017)... ... , ... Carlos Gutierrez has lived his spiritual life hardly without ... is the purpose of everyone in this universe. As Gutierrez sees the need of ... attempts to guide readers to expand one’s spiritual life. , “Our Spiritual Truths” deals ...
(Date:2/22/2017)... , ... February 22, 2017 , ... The Waismann ... the thousands of individuals who have recently fallen victim to America’s opioid epidemic. Now, ... Orange County, California, where they are free from the shame, stigma, and harmful ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... CITY, Calif. , Feb. 23, 2017 /PRNewswire/ ... pharmaceutical company focused on the development and commercialization ... acute pain, announced that it will release fourth ... on Thursday, March 2nd, 2017. AcelRx management will ... Eastern Time (1:30 p.m. Pacific Time) on March ...
(Date:2/23/2017)... COTTAGE, New York , February 23, 2017 /PRNewswire/ ... health implications arising from increasing caseload for varicose veins ... recorded across the globe are prompting the adoption of ... latest study on global endovenous laser therapy ... attention towards aftereffects of lifestyle choices and consequences of ...
(Date:2/23/2017)... Research and Markets has announced the addition of the "Global ... report to their offering. ... The Global Endoscopy Market is poised to grow at ... approximately $47.6 billion by 2025. This industry report ... on global as well as regional levels presented in the research ...
Breaking Medicine Technology: