Navigation Links
Bladder Pacemaker For Incontinence

Biomedical engineering researchers from Duke University have come out with a device which is likely// to be of significance in patients who suffer from bladder control issues.

They have named this as ‘smart bladder pacemaker’ that breaks into the urinary circuit in spinal cord which is responsible for the contraction and release of muscles which is essential to sustain continence. This device is extremely useful in patients suffering from spinal cord injuries and neurological disorders.

Warren Grill of Duke's Pratt School of Engineering and his colleagues have shown in cats that electrical stimulation can engage the spinal circuitry to effectively empty the bladder, while delivery of lower frequency pulses to the same nerve can significantly increase bladder capacity and improve continence.

In fact, manipulating the nervous system provides a more flexible way of influencing urinary function than would direct bladder stimulation, Grill said.

"Stimulating the bladder directly can cause it only to contract, not to keep it from contracting," Grill said. "We stimulate the sensory inputs in the spinal cord to orchestrate either the inhibition or activation of urination.

"This illustrates an important principle: we can use the 'smarts' of the nervous system to orchestrate control of complex functions," he said.

A similar approach might also have potential for stimulating the spinal reflexes that control locomotion, Grill added. Other investigators are testing such a system for use in physical therapy for people suffering from some form of paralysis, to help them learn to walk again.

Grill presented the team's findings on Friday, Feb. 16, at the annual meeting of the American Association for the Advancement of Science in San Francisco. His presentation was part of a symposium organized through the National Academies' Keck Futures Initiative. The research was supported by the National Institutes of Hea lth and the Paralyzed Veterans of America Spinal Cord Research Foundation.

Individuals with severe spinal cord injuries generally cannot empty their bladders voluntarily, Grill said. Spinal cord injuries also can cause the bladder to become involuntarily overactive, contracting at low volume for ineffective release of urine.

Ineffective emptying of the bladder can lead to complications, including damage to the bladder and frequent urinary tract infections, he said. Therefore, most people with spinal cord injuries are fitted with catheters that carry away urine.

The Duke researchers recently showed in cats that intermittent stimulation of the pelvic nerve that controls the urinary spinal circuitry emptied 65 percent of the bladder volume. The electrical pulses were delivered at a high frequency, mimicking the normal rate of sensory nerve impulses.

"We knew that the sensory fibers that excite the bladder normally fire at a rate of 30 to 40 impulses per second," Grill said. "We used the same rate to trick the circuit to turn on."

In another study, the researchers investigated the use of lower frequency electrical pulses for blocking unwanted bladder contractions. Earlier studies found that continuous low-frequency pulses of the pelvic nerve can suppress involuntary bladder contractions to maintain continence and increase bladder volume by 60 to 110 percent.

However, Grill suspected that the method could be made even more successful by making it more selective, delivering inhibitory pulses only in response to bladder contractions rather than constantly.

"The sensory system is designed to ignore signals if they are delivered constantly," Grill said. An everyday example of this "habituation" effect is the way people become accustomed to the pressure of a watch against the skin and no longer feel it, he said.

Indeed, the researchers found that inhibiting the urinary circuit only when contractio ns were detected increased bladder capacity by another 15 percent over continuous stimulation.

The researchers monitored bladder contractions indirectly by recording electrical nerve impulses, a sensing method that could be readily incorporated into a device resembling a pacemaker, Grill said.

"We relied on electrical recording of nerve activity that is coincident with bladder contraction to deliver a conditional inhibitory stimulus," Grill said. "It's a fully bioelectric and practical way to improve urinary continence."

The team now is working with Duke University Medical Center researchers on a clinical feasibility study to examine the urinary reflexes of human patients with spinal cord injuries.-Duke University



Source-Eurekalert
JY
'"/>




Related medicine news :

1. Chemotherapy Effective for Bladder Cancer
2. Dogs Can Sense Bladder Cancer
3. More Causes of Bladder Cancer Identified
4. More Dependable Screening Test For Bladder Cancer
5. Marijuana-Derived Drug Promises Hope In Treating Bladder Infection
6. Shy Bladder Syndrome: A Social Phobia Or Functional Disorder Of Micturition?
7. Coaching In Labor Could Increase Bladder Problems
8. Measuring Urinary Protein Helps In Detecting Recurrent Bladder Cancer
9. Brain holds the key to Overactive Bladder
10. Smoking Marijuana Increases The Risk Of Bladder Cancer
11. Bladder Surgery Patients Warned About Risk Of Bladder Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/8/2016)... ... December 08, 2016 , ... California Senate Bill (SB) 863, signed into law ... in 2013 and 2014, according to CompScope™ Medical Benchmarks for California, 17th Edition ... to the study, medical payments per claim in California decreased 4 percent in 2013 ...
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... ... and the Affordable Care Act. Dr. Botelho advocates for the mass media launching ... movement gives people ongoing opportunities to share their unfortunate experiences; such a movement ...
(Date:12/8/2016)... , ... December 08, 2016 , ... ... financial planning services from offices headquartered in Little Rock, has initiated a charity ... According to the National Foundation to End Senior Hunger, Arkansas ranks first in ...
(Date:12/8/2016)... ... 08, 2016 , ... The Dan Carlisle Agency, an Alabama-owned ... is announcing the launch of a charity drive to raise support and awareness ... and children in Birmingham has grown steadily since the 1980’s, and the Pathways ...
(Date:12/8/2016)... ... December 08, 2016 , ... Coppin Insurance Agency, an insurance ... in and around the Cape Coral area, is embarking on a charity drive with ... Southwest Florida. , The Harry Chapin Food Bank of Southwest Florida works to provide ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... , Dec. 8, 2016  A new study by ... the use of opioid therapy to treat chronic pain ... likelihood of more harmful consequences, including death. ... and Zankhana Mehta , M.D., authored the study ... chronic opioid therapy. The study was published in the ...
(Date:12/8/2016)... 2016 Mederi Therapeutics Inc . hat die behördliche Zulassung ... für gastroösophageale Refluxerkrankung (GERD) – in China angekündigt. ... ... Live Stretta procedure performed and broadcast ... of Endoscopy at Wuhan Union Hospital ...
(Date:12/8/2016)... 2016 According to the research report, ... is expected to be worth US$9.7 bn by the ... Between the forecast years of 2016 and 2024, the global ... The leading players operating in the global diabetes injection pens ... plc., Biocon Ltd., and Sanofi S.A. Transparency Market Research reports ...
Breaking Medicine Technology: