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Bladder Control following Weight loss in women with Prediabetes

Urinary continence can be reduced through losing weight by dietary changes and increased physical activity in women with prediabetes, which is a condition where blood glucose// levels are higher than normal but have not yet become diabetic.

These are the results of a new study that was published in the February issue of Diabetes Care, of women who participated in the Diabetes Prevention Program (DPP), a clinical study funded by the National Institutes of Health (NIH).

DPP’s results announced in 2001 and reported in 2002 revealed that losing 5 to 7 percent of weight through diet as well as a consistent increase in physical activity reduced the onset of type 2 diabetes by 58 percent. In addition treatment with metformin lowered the chances of developing diabetes by 31 percent.

NIH Director Elias A. Zerhouni, M.D said, “To combat the dual epidemics of obesity and type 2 diabetes, Americans need to know about the proven benefits of losing some weight through calorie reduction and increased physical activity.”

The DPP randomly assigned 3,234 overweight people with above normal blood glucose levels to one of three approaches to prevent type 2 diabetes: dietary changes and increased physical activity aimed at a 7-percent weight loss; treatment with the oral diabetes drug metformin; or placebo. The last two groups were also given standard medical advice about diet and weight loss. In the study, 660 women were randomly assigned to intensive lifestyle changes, 636 to metformin treatment, and 661 to placebo. Their average age was 50 years old, with an average body mass index of 35 (e.g., a 5’ 4” woman weighing 204 pounds). It was found that women who implemented intensive lifestyle changes and lost 5 to 7 percent of their weight had fewer episodes of weekly incontinence compared to those in the metformin or placebo groups.

Lead author Jeanette S. Brown, M.D., of the University of California, San Francisco said, “O
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