Navigation Links
Biopsies Of Human Skin And Bone Marrow Support T Cell Development

Recent research suggests that biopsies of human skin and bone marrow can provide the basis for the generation of a new, patient-specific T cell repertoire. T cells generated in skin cell cultures are diverse, mature, functional, and tolerant to self-MHC//.

T cells play a central role in the human adaptive immune system, discriminating self from non-self, directing less specific elements of the immune system in the performance of effector functions, and serving as a repository for immunologic memory.

The ability to generate T cells suitable for use in human patients could lead to significant advances in the treatment of immunodeficiencies and malignancies. Such therapies have not yet been realized because the unique requirements for T cell development are difficult to replicate in vitro.

The authors, writing in the November issue of The Journal of Clinical Investigation report that fibroblasts and keratinocytes from human skin arrayed on a synthetic 3-dimensional matrix support the development of functional human T cells from hematopoietic precursor cells in the absence of thymic tissue.

The researchers from Harvard Skin Disease Research Center and Department of Dermatology, Brigham and Women’s Hospital, Harvard Institutes of Medicine, Boston, Massachusetts, USA, found that newly generated T cells contained T cell receptor excision circles, possessed a diverse T cell repertoire, and were functionally mature and tolerant to self MHC, indicating successful completion of positive and negative selection.

Skin cell cultures expressed three transcription factors and a panel of autoantigens.

The authors conclude that skin and bone marrow biopsies can thus be used to generate de novo functional and diverse T cell populations for potential therapeutic use in immunosuppressed patients.


'"/>




Page: 1

Related medicine news :

1. More Accurate "PROSTATE CANCER" Test can save Unnecessary Biopsies
2. eSie Touch Elasticity Imaging, and a Promise of Avoiding Breast Biopsies
3. MRI-safe Motor Makes Robotic Biopsies Possible
4. MRI Robotic Biopsies Simplified by PneuStep
5. Human Genome Project Achieves Technological Triumph
6. First Vaccine Designed for Africa Cleared for Testing in Humans
7. Human gene number increases
8. Scientists found ancient Human Germ Killer
9. New standards for Human Research Safety
10. Human wasting disease linked to a gene
11. The Human Mad Cow Case
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his ... David Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps ... in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Conventional wisdom ... of success. In terms of the latter, setting the bar too high can result ... more than just slow progress toward their goal. , Research from PsychTests.com ...
(Date:6/24/2016)... Michigan (PRWEB) , ... June 24, 2016 , ... June ... about the dangers associated with chronic pain and the benefits of holistic treatments, ... individuals who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that ... chosen by their peers for this recognition are considered among the top 2 percent ... special honors as members of this year’s Legal Elite Hall of Fame: Miami ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief ... a minimum wage raise to $12 an hour by 2020 and then adjusting it yearly ... lost value of the minimum wage, assure the wage floor does not erode again, and ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the ... 2016 - Forecast to 2022" report to their offering. ... up to date financial data derived from varied research sources ... with potential impact on the market during the next five ... comprises of sub markets, regional and country level analysis. The ...
(Date:6/23/2016)... MOUNTAIN VIEW, Calif. , June 23, 2016 ... 9:00 a.m. CST on Thursday, July 7, 2016 , , ... kayla.belcher@frost.com ) , , , , EXPERT PANELISTS:  ... Sciences, Nitin Naik; Senior Industry Analyst, Christi Bird; Senior Industry Analyst, ... The global pharmaceutical industry is witnessing ...
(Date:6/23/2016)...  Guerbet announced today that it has been named ... . One of 12 suppliers to receive ... support of Premier members through exceptional local customer service ... to lower costs. ... outstanding customer service from Premier," says Massimo Carrara ...
Breaking Medicine Technology: