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Biomarkers Found Harmful For Human Lupus

A team of Wake Forest University School of Medicine has found biomarkers for lupus that may play a role in causing the disease. //The biomarkers are micro-ribonucleic acids (micro-RNAs), said Nilamadhab Mishra, M.D.

Mr. Mishra and his colleagues reported at the American College of Rheumatology meeting in Washington that they had found profound differences in the expression of micro-RNAs between five lupus patients and six healthy control patients who did not have lupus.

'We are the first to show that these micro-RNAs are a problem in human lupus,' said Mishra, an assistant professor of rheumatology.

Mishra said microRNAs are a class of small chains of ribonucleic acid that have important regulatory functions in the body, particularly in suppressing genes (RNA serves as the template for translation of genes into proteins).

The research is part of Mishra's broader focus on histones, the tiny spools in the nuclei of cells around which DNA winds and compacts when it is not in the process of copying in cell division. Changes in these histones, called epigentic changes, can alter gene expression and the proteins these genes produce without altering the underlying DNA.

In the new study, the researchers found 40 microRNAs in which the difference in expression between the lupus patients and the controls was more than 1.5 times, and focused on five micro-RNAs where the lupus patients had more than three times the amount of the microRNAs as healthy controls, and one, called miR 95 where the lupus patients had just one third of the gene expression of the micro-RNA of the controls.

The team reported the lesser amount of miR 95 'results in aberrant gene expression in lupus patients.'

Furthermore, Mishra said, the microRNAs are associated with enzymes called histone deacetylases, which provide 'further rationale for the use of histone deacetylase inhibitors (HDIs) for the treatment of lupus.' Mishra has shown
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