Navigation Links
Biomarkers Could Prove Significant In Understanding Aging Process

Researchers at the Vanderbilt University Medical Center have zoned in on new molecular indicators, called "biomarkers", // for aging of the skin that could be an interesting pointer when evaluating anti-aging therapies. The findings of this particular study are reported in the latest issue of the Journal of Investigative Dermatology.

“There's a lot of interest in the pharmaceutical and cosmetic industries in developing products that will minimize or reduce certain signs of aging,” said James Sligh Jr., M.D., Ph.D., assistant professor of Medicine and Cell & Developmental Biology. “The quantifiable biomarkers we've characterized could be useful for monitoring laboratory-simulated aging as well as potential drugs or therapies that alter the aging process.” The reserachers focused on the DNA of cellular organelles called mitochondria, which are known as the "power house" of the cell owing to their ability to generate energy that is vital for various cell processes to take place. “We initiated this project with the idea that perhaps there was a specific mitochondrial DNA deletion signature that would be associated with tumor development in the skin,” Sligh said. The team found to their surprise that there were some mutational deletions in tumor-free samples as well. The tumor samples were more likely to have full-length mitochondrial DNA, Sligh said, rather than significant mutations. “Unraveling the molecular clues as to why aging cells function differently than young cells requires that we have molecular markers that we can track,” Sligh said. “It won't be long before other investigators who have other human tissue specimens — brain, lung, heart, for example — look for these changes and report back. It will be interesting to see if the mitochondrial DNA mutations we've found are markers of aging in other tissues or if they are specific to tissues exposed to ultraviolet light.”

Alex Eshaghian, an MSTP student, and former VU medical student Ruth Ann Vleugels, M.D., are the lead authors of the paper. Other contributors include Jeffrey Canter, M.D., Michel McDonald, M.D., and Thomas Stasko, M.D. The research was supported by the VA Medical Research Service, Vanderbilt Skin Diseases Research Center, Ellison Medical Foundation and American Cance Society.
'"/>




Related medicine news :

1. Biomarkers May Indicate Alzheimers Disease
2. Researchers Find Mix of Biomarkers Predicting Mortality
3. Biomarkers Predicting Mortality Found Using Statistical Technique
4. Biomarkers Found Harmful For Human Lupus
5. Researchers Find Two Biomarkers With Potential to Predict Breast Cancer Spread
6. Biomarkers Ability to Predict Heart Disease and Stroke is Limited
7. Probable Biomarkers for Squamous Cell Carcinoma
8. New Genetic Biomarkers Could Predict Coronary Heart Disease
9. Lean Protein Could Be Key to Obesity Drugs
10. Nasal Spray Could Take Drugs Direct to Brain.
11. Nasal Spray Could Take Drugs Directly to Brain
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out of ... verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida ... their peers for this recognition are considered among the top 2 percent of lawyers ... as members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San ... Society and the Road To Recovery® program to drive cancer patients to and from ... adults to ensure the highest quality of life and ongoing independence. Getting to ...
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing skills ... patients and their families pay tribute to a genetic counselor by nominating him or ... Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome magazine ...
(Date:6/24/2016)... New York, NY (PRWEB) , ... June 24, ... ... lifestyle publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as ... believes that “the most beautiful women in the world, and the most handsome ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Bracket , a leading clinical trial technology ... outcomes platform, Bracket eCOA (SM) 6.0, at the 52 ... 30, 2016 in Philadelphia , Pennsylvania.  A ... product of its kind to fully integrate with RTSM, will ... 6.0 is a flexible platform for electronic clinical outcomes assessments ...
(Date:6/23/2016)... RIDGE, Ill. and INDIANAPOLIS ... of students receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship ... The 2016 scholarship winners, announced today online at ... to let type 1 diabetes stand in the way ... Diabetes has supported the Foundation,s scholarship program since 2012, ...
(Date:6/23/2016)... 23, 2016 Revolutionary technology includes ... Oticon , industry leaders in advanced audiology and hearing ... Oticon Opn ™, the world,s first internet connected hearing ... IoT devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ... number of ,world firsts,: , TwinLink™ - ...
Breaking Medicine Technology: