Navigation Links
Biomarkers Could Prove Significant In Understanding Aging Process

Researchers at the Vanderbilt University Medical Center have zoned in on new molecular indicators, called "biomarkers", // for aging of the skin that could be an interesting pointer when evaluating anti-aging therapies. The findings of this particular study are reported in the latest issue of the Journal of Investigative Dermatology.

“There's a lot of interest in the pharmaceutical and cosmetic industries in developing products that will minimize or reduce certain signs of aging,” said James Sligh Jr., M.D., Ph.D., assistant professor of Medicine and Cell & Developmental Biology. “The quantifiable biomarkers we've characterized could be useful for monitoring laboratory-simulated aging as well as potential drugs or therapies that alter the aging process.” The reserachers focused on the DNA of cellular organelles called mitochondria, which are known as the "power house" of the cell owing to their ability to generate energy that is vital for various cell processes to take place. “We initiated this project with the idea that perhaps there was a specific mitochondrial DNA deletion signature that would be associated with tumor development in the skin,” Sligh said. The team found to their surprise that there were some mutational deletions in tumor-free samples as well. The tumor samples were more likely to have full-length mitochondrial DNA, Sligh said, rather than significant mutations. “Unraveling the molecular clues as to why aging cells function differently than young cells requires that we have molecular markers that we can track,” Sligh said. “It won't be long before other investigators who have other human tissue specimens — brain, lung, heart, for example — look for these changes and report back. It will be interesting to see if the mitochondrial DNA mutations we've found are markers of aging in other tissues or if they are specific to tissues exposed to ultraviolet light.”

Alex Eshaghian, an MSTP student, and former VU medical student Ruth Ann Vleugels, M.D., are the lead authors of the paper. Other contributors include Jeffrey Canter, M.D., Michel McDonald, M.D., and Thomas Stasko, M.D. The research was supported by the VA Medical Research Service, Vanderbilt Skin Diseases Research Center, Ellison Medical Foundation and American Cance Society.
'"/>




Related medicine news :

1. Biomarkers May Indicate Alzheimers Disease
2. Researchers Find Mix of Biomarkers Predicting Mortality
3. Biomarkers Predicting Mortality Found Using Statistical Technique
4. Biomarkers Found Harmful For Human Lupus
5. Researchers Find Two Biomarkers With Potential to Predict Breast Cancer Spread
6. Biomarkers Ability to Predict Heart Disease and Stroke is Limited
7. Probable Biomarkers for Squamous Cell Carcinoma
8. New Genetic Biomarkers Could Predict Coronary Heart Disease
9. Lean Protein Could Be Key to Obesity Drugs
10. Nasal Spray Could Take Drugs Direct to Brain.
11. Nasal Spray Could Take Drugs Directly to Brain
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2017)... Texas (PRWEB) , ... January 20, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at ... the bible in homes across the world. Yisrayl says this generation is a time like ... is to turn to the Bible. , Yisrayl says he does not want to sound ...
(Date:1/20/2017)... , ... January 20, 2017 , ... Lice Troopers, the ... cases in families with school-aged children since the holiday season. , “It happens ... with their families, sharing hugs and taking photos, which is the head-to-head gateway that ...
(Date:1/20/2017)... ... ... "TransFlare 4K Mystique comes with 44 colorful mysterious transitions that are fully ... - CEO of Pixel Film Studios. , TransFlare 4K Mystique contains 44 lens ... and light leak transitions have a very high-dynamic range for super smooth falloff. Simply ...
(Date:1/20/2017)... ... 2017 , ... “Code Word: Chocolate Biscuit”: a biographical account following a man who went on ... of published author, Marlyn Ivey, born in Lynn Haven, Florida and at the age of ... 19 years of age, he joined the Navy and got married right out of boot ...
(Date:1/20/2017)... ... 20, 2017 , ... “Journey to Christmas:” a beautiful and enchanting tale that teaches children the ... a mother of three in Oklahoma City, and a devoted woman of faith. , ... has been in the back of my mind for years, but actually doing it might ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... , January 20, 2017 Avillion LLP, ... appointment of Mark Weinberg , MD MBA as Chief Medical ... , USA . ... Dr Weinberg has spent more than 17 years ... 20" pharma companies to micro-cap biotech. Over the course of his ...
(Date:1/19/2017)... The Global Therapy Partnering Terms and Agreements ... deals and agreements entered into by the world,s leading ... Top deals by value - Deals listed by company ... The report provides understanding and access to the partnering ... healthcare companies. The report provides an analysis of ...
(Date:1/19/2017)... Jan. 19, 2017 This report on the ... future scenario of the global market. Large number of ... Severe chronic constipation is a major side effect of ... Hence, novel targeted therapy has been prescribed to treat ... of targeted medicines, and growing awareness about the therapy ...
Breaking Medicine Technology: