Navigation Links
Biomarkers Could Prove Significant In Understanding Aging Process

Researchers at the Vanderbilt University Medical Center have zoned in on new molecular indicators, called "biomarkers", // for aging of the skin that could be an interesting pointer when evaluating anti-aging therapies. The findings of this particular study are reported in the latest issue of the Journal of Investigative Dermatology.

“There's a lot of interest in the pharmaceutical and cosmetic industries in developing products that will minimize or reduce certain signs of aging,” said James Sligh Jr., M.D., Ph.D., assistant professor of Medicine and Cell & Developmental Biology. “The quantifiable biomarkers we've characterized could be useful for monitoring laboratory-simulated aging as well as potential drugs or therapies that alter the aging process.” The reserachers focused on the DNA of cellular organelles called mitochondria, which are known as the "power house" of the cell owing to their ability to generate energy that is vital for various cell processes to take place. “We initiated this project with the idea that perhaps there was a specific mitochondrial DNA deletion signature that would be associated with tumor development in the skin,” Sligh said. The team found to their surprise that there were some mutational deletions in tumor-free samples as well. The tumor samples were more likely to have full-length mitochondrial DNA, Sligh said, rather than significant mutations. “Unraveling the molecular clues as to why aging cells function differently than young cells requires that we have molecular markers that we can track,” Sligh said. “It won't be long before other investigators who have other human tissue specimens — brain, lung, heart, for example — look for these changes and report back. It will be interesting to see if the mitochondrial DNA mutations we've found are markers of aging in other tissues or if they are specific to tissues exposed to ultraviolet light.”

Alex Eshaghian, an MSTP student, and former VU medical student Ruth Ann Vleugels, M.D., are the lead authors of the paper. Other contributors include Jeffrey Canter, M.D., Michel McDonald, M.D., and Thomas Stasko, M.D. The research was supported by the VA Medical Research Service, Vanderbilt Skin Diseases Research Center, Ellison Medical Foundation and American Cance Society.
'"/>




Related medicine news :

1. Biomarkers May Indicate Alzheimers Disease
2. Researchers Find Mix of Biomarkers Predicting Mortality
3. Biomarkers Predicting Mortality Found Using Statistical Technique
4. Biomarkers Found Harmful For Human Lupus
5. Researchers Find Two Biomarkers With Potential to Predict Breast Cancer Spread
6. Biomarkers Ability to Predict Heart Disease and Stroke is Limited
7. Probable Biomarkers for Squamous Cell Carcinoma
8. New Genetic Biomarkers Could Predict Coronary Heart Disease
9. Lean Protein Could Be Key to Obesity Drugs
10. Nasal Spray Could Take Drugs Direct to Brain.
11. Nasal Spray Could Take Drugs Directly to Brain
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/23/2017)... ... February 23, 2017 , ... Thomas Vas-Don suffered from ... regime, the author was able to successfully recover. In “ Origin & Insertion Charts ... various sources on the principals of massage, anatomy , trigger points and ...
(Date:2/22/2017)... York, NY (PRWEB) , ... February 22, 2017 ... ... professional life and athletics. It’s enough to overwork even the sharpest brain. , ... that offer peak healthy activity without over clocking the brain. Each capsule contains ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... The ... to the thousands of individuals who have recently fallen victim to America’s opioid epidemic. ... in Orange County, California, where they are free from the shame, stigma, and ...
(Date:2/22/2017)... ... February 22, 2017 , ... South Bend’s Lunkerville, the award-winning TV series that ... On The Water (HOW), a non-profit organization dedicated to helping military veterans relax, rehabilitate, ... ‘Mike D’ traveling to Lake Denmark, New Jersey, to fish with war veteran Justin ...
(Date:2/22/2017)... ... February 22, 2017 , ... In a 2012 survey, over ... not filling a prescription because they could not afford to pay for it. ... were 30-60%*. At the same time, hospitals, pharmacies, manufacturers and nursing ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... 22, 2017  Andre, DiMino, CEO of ADM Tronics ... of innovative technologies and products, commented on ADMT,s third ... 21, 2017 in the Company,s quarterly report on Form ... CEO Andre, DiMino stated "During the quarter ended December ... devoting a larger portion of our engineering efforts into ...
(Date:2/22/2017)... Feb. 22, 2017  Ultra Clean Holdings, Inc. ... critical systems and subsystems for the semiconductor capital ... today reported its financial results for the fourth ... "2016 was a year of extraordinary ... reached record highs and together with continued focus ...
(Date:2/22/2017)... Feb. 22, 2017 Summary Provides ... and agreements entered into by the worlds leading healthcare ... Description The Global Spinal Cord Partnering Terms and ... partnering deals and agreements entered into by the world,s ... deals - Top deals by value - ...
Breaking Medicine Technology: