Navigation Links
Biomarkers Ability to Predict Heart Disease and Stroke is Limited

A study of the use of biomarkers to predict the risk of cardiovascular disease and death in an apparently healthy population has found that, even though some measurements// are associated with future cardiovascular events, their usefulness for predicting risk in individuals may be limited. The report from the Framingham Heart Study appears in the Dec. 21 New England Journal of Medicine.

"We found that several contemporary biomarkers were associated with future cardiovascular disease or death, over and above what was indicated by established risk factors; but even in combination their utility for risk prediction was modest," says Thomas J. Wang, MD, of the Massachusetts General Hospital (MGH) Division of Cardiology, the report’s lead author. "High biomarker levels can successfully identify groups of people at risk, but their ability to predict an individual person’s risk – a goal of ‘personalized medicine’ – is still limited."

Many previous studies have identified potential biomarkers – laboratory measurements that may indicate a particular biological state – of cardiovascular risk. These include blood levels of C-reactive protein, B-type natriuretic peptide (BNP), and homocysteine, elevated levels of which have been associated with increased risk. However, few studies have looked at the use of multiple biomarkers, either to compare their usefulness or to evaluate the testing of several markers at once.

The current study was designed specifically to look at the ability of a multimarker testing approach to evaluate cardiovascular risk in a group of apparently healthy individuals. Participants were members of the Framingham Offspring Study, which follows a group of adult children of participants in the original Framingham Heart Study to evaluate risk factors for the development of cardiovascular disease. During participants’ regular study visits between 1995 and 1998, they were tested for 10 potential biomarkers of cardiovascular ri sk, along with the usual history, physical examination and other assessments taken as part of the overall Offspring Study. Those known to have a prior heart attack or stroke were excluded from the biomarker study.

Among the 3,200 participants in the biomarker study, 169 experienced a major cardiovascular event – such as heart attack, stroke or cardiac death – during the study period of up to 10 years. The biomarkers that proved most useful in predicting future cardiovascular events were BNP and urinary albumin content. BNP appeared to be a stronger predictor of risk than C-reactive protein, possibly the best-known cardiovascular biomarker. However, even though those with high multimarker scores had twice the risk of a cardiovascular event as those with low scores, the information provided by the biomarkers only slightly improved predictions based on such conventional risk factors as hypertension, cholesterol levels and smoking.

"There has been a great deal of enthusiasm among cardiologists over the potential of biomarkers, but our findings suggest that we need to identify additional biomarkers to be able to predict individual risk in a useful fashion," says Wang. "Newer biological approaches, such as genomics and proteomics, may give us tools that can help identify these new biomarkers." Wang is an assistant professor of Medicine at Harvard Medical School.

"This important study shows that conventional risk factors have stood the test of time and are still good predictors of risk, while at the same time adding to the growing body of information on novel biomarkers," says Elizabeth G. Nabel, MD, director of the National Heart, Lung and Blood Institute (NHLBI), which sponsors the Framingham Heart Study. "Although there was only a modest improvement in risk assessment when new risk factors were added to conventional ones, it was enough to show the potential value of the newer markers. We look to further research to identify other b iomarkers that are more predictive of risk, which could also have implications for the development of new treatments for cardiovascular disease."

Source-Eurekalrt
SRM
'"/>




Related medicine news :

1. Biomarkers May Indicate Alzheimers Disease
2. Biomarkers Could Prove Significant In Understanding Aging Process
3. Researchers Find Mix of Biomarkers Predicting Mortality
4. Biomarkers Predicting Mortality Found Using Statistical Technique
5. Biomarkers Found Harmful For Human Lupus
6. Researchers Find Two Biomarkers With Potential to Predict Breast Cancer Spread
7. Probable Biomarkers for Squamous Cell Carcinoma
8. New Genetic Biomarkers Could Predict Coronary Heart Disease
9. Soya Found To Affect Womens Ability To Conceive: Professor
10. Humans Found To Have The Ability To Block Unwanted Memories
11. Watching Violent, Churning Movie Scenes Affect Problem-Solving Ability
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... ProVest Insurance ... greater Dallas, Miami, and Raleigh regions, is organizing an extended charity drive to ... and deadly chromosome abnormality. , After struggling since birth with several health challenges, ...
(Date:10/13/2017)... Ky. (PRWEB) , ... October 13, 2017 , ... The ... MPH to become its next President and Chief Executive Officer, succeeding Dr. James C. ... CEO Elect beginning July 1, 2018 until Dr. Puffer’s retirement at the end of ...
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of ... ElderCounsel, a national organization of elder law and special needs planning attorneys. “Membership in ... It also provides a forum to network with elder law attorneys nationwide,” said Somekh. ...
(Date:10/13/2017)... ... 13, 2017 , ... Ellevate Network, the leading network for professional women, brought ... gender equality at their inaugural Summit in New York City in June. The event ... audience of over 3 million. To watch the Mobilize Women video, click here ...
(Date:10/13/2017)... VA (PRWEB) , ... October 13, 2017 , ... ... of DevOps and Agile Software Development, has been awarded a contract by the ... Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... 12, 2017 AVACEN Medical , Inc. (AVACEN) ... their  2017 New Product Innovation Award for Its fibromyalgia ... and secondary medical device market research by Frost & Sullivan,s ... OTC, drug-free pain relief product, the AVACEN 100, offers a ... fibromyalgia widespread pain. ...
(Date:10/11/2017)... 2017  True Health, a leader in integrated ... during National Breast Cancer Awareness month to educate ... Research recently published ... more than 10 million American women are at ... or BRCA2 and have not had testing. These mutations ...
(Date:10/5/2017)...  In response to the nationwide opioid epidemic, ... (AAOMS) released prescribing recommendations that urge ibuprofen – ... a first-line therapy to manage a patient,s acute ... Recognizing the value and importance of the ... Acute and Postoperative Pain Management" stresses that practitioners ...
Breaking Medicine Technology: