( rch on biologics has shown that for pat...)Biologics valuable treatment option for patients with inflammatory bowel disease,Health

rch on biologics has shown that for patients in whom traditional therapies may not work, biologics may be appropriate as a first line treatment. However, IBD is a heterogeneous disease and some patients may not respond to biologics, so the appropriate role of these agents in the treatment paradigm is the subject of much discussion. In determining the appropriate course of treatment for their patients, gastroenterologists need to balance the potential complications of drug treatment (including increased risk for infections and cancer) against the consequences of potential under-treatment of their patients’ disease (including poor quality-of-life, complications of disease, and the costs associated with active disease and the treatment of complications). The decision of how to treat patients requires extensive knowledge of treatment options and the patient, including whether intense therapy is needed and who may respond to biologic agents. But many factors remain unknown and many important outcomes remained undefined or poorly quantifiable, such as reliable evidence of disease modification and reduction in disability.

The role of biologics for the treatment of patients with IBD continues to evolve and is dependant on researchers determining the answers to a number of outstanding questions about appropriate markers of prognosis and response, the use of biologics as limited or bridge therapy and its duration, the applicability of biologics early in disease, and the potential of disease modification. In order to determine the answers to these and other potentially important questions, more research is needed about the natural history of IBD and its complications, as well as the complications biologic therapy. Additionally, long-term data about the effects of biologic therapy on hospitalizations, surgeries and other outcomes must be gathered and the relationship between disease improvement and these outcomes must be studied.

According to the U.S. Food and
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