Navigation Links
Bioengineering production strains - Microbia develops new methods

The recently published issue of Nature Biotechnology outlines a new method developed by Microbia Ltd.'s scientists for rapidly identifying genes required for the production of industrial molecules produced in microbes. This is an advancement in the company's ability to improve the properties// of microbial cells for biomanufacturing pharmaceuticals and fine chemicals. This new technology enables the illumination of the best route to optimize a cell's metabolic potential to increase productivity and yield of drugs and chemicals manufactured at industrial scale.

Microbia's Senior Director for Biomanufacturing Business Development, Richard Bailey, said that the scientists at Microbia had used a systems approach to engineer the microbial circuitry that regulates metabolite production. He added that the scientists had illustrated how they develop the roadmap for these regulatory networks and once they pinpointed the key genes to be modulated, such as those contributing to high productivity, they will be able to selectively alter them to boost yields and improve other production parameters.

The Nature Biotechnology authors constructed genomic fragment microarrays for Aspergillus terreus and then utilized these arrays for transcriptional profiling of strains engineered to produce varying levels of lovastatin-a drug used widely to treat high cholesterol. By integrating transcriptional and metabolite data, the authors elucidated the key genetic components and critical regulatory nodes affecting lovastatin production.

The technology described is a component of Microbia's Precision Engineering approach to biomanufacturing process improvement. Precision Engineering provides a rapid and comprehensive alternative to traditional metabolic engineering methods by targeting the physiological control networks in fungal and bacterial cells.


'"/>




Page: 1

Related medicine news :

1. Digestive acid production dependent on newly found hormone
2. Roche confirms Tamiflu production talks in US
3. Pigs have another utility: production of healthy oils!
4. WHO takes initiative to fight corruption tainted medicine production-supply chain
5. African HIV strains more resistant to anti HIV drugs
6. E. coli strains resistant to a common antibiotic
7. Hormone restrains appetite in man
8. Fluorescent markers to distinguish Trypanosoma brucei strains causing Sleeping Sickness
9. Detection of Weak strains of bird flu virus – Target of European Unio
10. Resistant Influenza strains creates panic in US
11. Multiple infectious disease strains can coexist
Post Your Comments:
(Date:5/26/2015)... Virginia (PRWEB) May 26, 2015 U.S. ... devices in the United States are extensive and can ... consulting firm that helps medical device companies comply with ... help medical device companies navigate FDA requirements. , ... in the United States can be a lengthy process ...
(Date:5/26/2015)... Carl W. Berk, M.D. and his ... Pinehurst, N.C. have launched a Balloon Sinuplasty website to ... sinusitis and the benefits of Balloon Sinuplasty. , The ... determine if someone is a good candidate for Balloon ... factors that can contribute to chronic nasal congestion. If ...
(Date:5/25/2015)... May 26, 2015 The National ... as a 2015-2016 inductee into its VIP Professional Woman ... prestigious distinction for leadership in dentistry. NAPW is the ... more than 700,000 members and over 200 operating local ... this exceptional group of professional women,” said NAPW President ...
(Date:5/25/2015)... (PRWEB) May 25, 2015 World Patent ... products, announces the Hidee-Hose, an undergarment patent that allays ... "The Global Women's Hosiery industry forecasts the market to ... CEO and Creative Director of World Patent Marketing ... is steering ahead and is expected to maintain its ...
(Date:5/25/2015)... 2015 Thousands of DePuy Pinnacle ... in the federal multidistrict litigation now underway in ... to a Motion filed on May 20th, plaintiffs’ ... Case Management Order pertaining to the Limited Authorization ... Motion seeks the adoption of a new form ...
Breaking Medicine News(10 mins):Health News:FDA Medical Device Regulations: Top 10 Tips for Marketing a Device in the USA 2Health News:FDA Medical Device Regulations: Top 10 Tips for Marketing a Device in the USA 3Health News:FDA Medical Device Regulations: Top 10 Tips for Marketing a Device in the USA 4Health News:Pinehurst Surgical Sinus Center Launches Pinehurst Balloon Sinuplasty Website 2Health News:National Association of Professional Women Inducts Dr. Laquinas Hooked, D.D.S. of General Dentist, Into its VIP Professional Woman of the Year Circle 2Health News:For The Courtesy Of Women's Health And Looks - World Patent Marketing Presents A New Undergarment Patent 2Health News:For The Courtesy Of Women's Health And Looks - World Patent Marketing Presents A New Undergarment Patent 3Health News:Federal DePuy Pinnacle Hip Lawsuits Move Forward, as Plaintiffs Seek to Modify Order Pertaining to Health Authorizations 2Health News:Federal DePuy Pinnacle Hip Lawsuits Move Forward, as Plaintiffs Seek to Modify Order Pertaining to Health Authorizations 3
... trials in humans to treat obesity from a drug derived ... the Managing Director of the company. ,As per ... and each part of the plant has a different effect ... has the power to curb hunger, some other part of ...
... who wear a special kind of no-line bifocal lenses ... who wear more conventional lenses according to a new// ... Ophthalmology & Visual Science (IOVS). ,The ... myopia progression was slower in children wearing progressive-addition lenses ...
... February is National Children's Dental Health Month and as ... its Fifth Annual Give Kids A Smile Day on ... the ADA offers advice for parents and caregivers to ... ,"Preventive dental care has greatly improved the oral health ...
... pill-sized robot that can travel inside your body, can find ... to a computer//. ,After being swallowed, the robot ... Daily Mail. The miniature video camera fitted with the device ... ,The extraordinary invention by Alex Zivanovic of Imperial College, London, ...
... be bustling around hospital wards in as little as ... developed ground-breaking software//. ,The mechanised "nursebots" being ... such as mopping up spillages, taking messages and guiding ... distribute medicines and even monitor the temperature of patients ...
... if its treatment guidelines are followed, the death rate in ... 5%, but it is more common for 20% or over ... the deaths of 1.5 million children every year. ... Professor of Paediatrics in Blantyre, Malawi discusses whether the problem ...
Cached Medicine News:Health News:Good Oral Health Practices Should Begin in Infancy 2Health News:Robot Nurses Ready For Hospitals 'In Three Years' 2
(Date:5/22/2015)... Calif. , May 22, 2015 /PRNewswire/ ... the Company has commenced termination of its ... brodalumab with AstraZeneca (LON:AZN, STO:AZN and NYSE: ... inhibitor, is in development for patients with ... spondyloarthritis.  The decision was based on events ...
(Date:5/22/2015)... More than fifty years ago, Thalidomide was approved by Health ... Tragically, Thalidomide caused serious and permanent physical and emotional damage ... been provided to survivors over the years from sources including ... in 1991 and settlements from drug companies. ... support, we have a clear moral obligation to help meet ...
(Date:5/22/2015)... 2015  BioLife Solutions, Inc. (NASDAQ: BLFS ), a ... hypothermic storage and cryopreservation freeze media and ... ("BioLife" or the "Company"), announced that the Company is scheduled ... The Company is scheduled to present at the Conference ... the Grand Hyatt Hotel in New York City ...
Breaking Medicine Technology:Amgen to terminate participation in co-development and commercialization of brodalumab 2Amgen to terminate participation in co-development and commercialization of brodalumab 3Amgen to terminate participation in co-development and commercialization of brodalumab 4Amgen to terminate participation in co-development and commercialization of brodalumab 5Statement from Minister Ambrose on Thalidomide 2Statement from Minister Ambrose on Thalidomide 3BioLife Solutions To Present At The 2015 Marcum MicroCap Conference In New York City 2
... HAE ) announced that it has entered ... of Hemerus Medical, LLC, a Minnesota-based company that develops ... processing and storage of blood components.  Hemerus has completed ... Drug Application to the FDA for its unique, patented ...
... Inc. (NYSE: HRC ) invites you to listen ... Care Conference in Boston on May 8, 2012, at 8:00 ... the live discussion via the internet link at http://ir.hill-rom.com/events.cfm ... recorded replay of the discussion will be available one hour ...
Cached Medicine Technology:Haemonetics Signs Definitive Agreement To Acquire Hemerus Medical, LLC 2Haemonetics Signs Definitive Agreement To Acquire Hemerus Medical, LLC 3Haemonetics Signs Definitive Agreement To Acquire Hemerus Medical, LLC 4
... is a low-price PC-based, 2-8-channel system ... from the retina and the optic ... device, operator monitor, printer, keyboard, mouse, ... All electrical connections are easily to ...
... that allows to see the fundus picture ... Besides it also includes the refractive pupil ... the pupil picture and the fundus image ... especially suited for animal research and retina ...
5 mm...
Cannula and irrigation extension. Overall Length 150 mm (6.25"). Light Curve....
Medicine Products: