Navigation Links
Bioengineering production strains - Microbia develops new methods

The recently published issue of Nature Biotechnology outlines a new method developed by Microbia Ltd.'s scientists for rapidly identifying genes required for the production of industrial molecules produced in microbes. This is an advancement in the company's ability to improve the properties// of microbial cells for biomanufacturing pharmaceuticals and fine chemicals. This new technology enables the illumination of the best route to optimize a cell's metabolic potential to increase productivity and yield of drugs and chemicals manufactured at industrial scale.

Microbia's Senior Director for Biomanufacturing Business Development, Richard Bailey, said that the scientists at Microbia had used a systems approach to engineer the microbial circuitry that regulates metabolite production. He added that the scientists had illustrated how they develop the roadmap for these regulatory networks and once they pinpointed the key genes to be modulated, such as those contributing to high productivity, they will be able to selectively alter them to boost yields and improve other production parameters.

The Nature Biotechnology authors constructed genomic fragment microarrays for Aspergillus terreus and then utilized these arrays for transcriptional profiling of strains engineered to produce varying levels of lovastatin-a drug used widely to treat high cholesterol. By integrating transcriptional and metabolite data, the authors elucidated the key genetic components and critical regulatory nodes affecting lovastatin production.

The technology described is a component of Microbia's Precision Engineering approach to biomanufacturing process improvement. Precision Engineering provides a rapid and comprehensive alternative to traditional metabolic engineering methods by targeting the physiological control networks in fungal and bacterial cells.


'"/>




Page: 1

Related medicine news :

1. Digestive acid production dependent on newly found hormone
2. Roche confirms Tamiflu production talks in US
3. Pigs have another utility: production of healthy oils!
4. WHO takes initiative to fight corruption tainted medicine production-supply chain
5. African HIV strains more resistant to anti HIV drugs
6. E. coli strains resistant to a common antibiotic
7. Hormone restrains appetite in man
8. Fluorescent markers to distinguish Trypanosoma brucei strains causing Sleeping Sickness
9. Detection of Weak strains of bird flu virus – Target of European Unio
10. Resistant Influenza strains creates panic in US
11. Multiple infectious disease strains can coexist
Post Your Comments:
(Date:5/3/2015)... (PRWEB) May 03, 2015 Looking ... that will directly impact your career? The Master ... for dynamic leaders in multinational companies and for ... In a changing global landscape, differences in culture, ... relationships. The EMIB program develops the global competence ...
(Date:5/3/2015)... Hanover, MA (PRWEB) May 03, 2015 It is ... 3rd Annual Brain Aneurysm Walk in Memory of Lissa Anne Been ... of Lissa organized this great family-friendly event to honor her loving ... since its inception. , Just having turned 37, Lissa suffered ... Lissa passed away on August 24, 2012. This event is designed ...
(Date:5/2/2015)... Ticket Down has secured additional inventories of ... awaited event today, Saturday, May 2nd at the MGM Grand ... be able to secure tickets for both the actual fight ... fans have wanted for more than five years was finally ... will step inside the ring to fight Manny “Pac-Man” Pacquiao ...
(Date:5/2/2015)... 02, 2015 ProText Kinetic 2 is a ... Final Cut Pro X. ProText Kinetic 2 features 40 ... Final Cut Pro X . Easily create interactive text ... Film Studios' ProText Kinetic 2. , Using ProText Kinetic is ... two ProText Kinetic presets in the FCPX timeline. Playback ...
(Date:5/2/2015)... May 02, 2015 “ Peachtree Audio ... monthly Tech Report, which features the latest and coolest ... expert and special reporter for NewsWatch, conducted the review ... audio equipment. , Music is an important part ... be pampered and given the royal treatment. Peachtree Audio ...
Breaking Medicine News(10 mins):Health News:The Saint Louis University's Master of International Business Is Now Enrolling For Fall 2015 2Health News:Renowned Brain Aneurysm Foundation to Benefit from Arnold, Missouri’s 3rd Annual Brain Aneurysm Walk in Memory of Lissa Anne Been 2Health News:Cheap Floyd Mayweather vs. Manny Pacquiao Tickets: Ticket Down Has Last Minute Tickets for Mayweather vs. Pacquiao at the MGM Grand Garden Arena in Las Vegas 2Health News:Cheap Floyd Mayweather vs. Manny Pacquiao Tickets: Ticket Down Has Last Minute Tickets for Mayweather vs. Pacquiao at the MGM Grand Garden Arena in Las Vegas 3Health News:Pixel Film Studios Announced the Release of Protext Kinetic 2 for FPCX. 2Health News:Affordable High-End Audio Equipment was Featured on NewsWatch Television 2
... Cyberonics, Inc. (Nasdaq: CYBX ) today announced results for the ... , Results for the second quarter of fiscal 2010 compared ... sales of $40.7 million, a 13% increase from $36.0 million; ... the prior year; U.S. and international epilepsy unit sales increased ...
... Don,t ignore foot pain on the dance floor , CHICAGO, ... not entirely true; dancing the night away can take a toll ... foot injuries that can stop the show, as witnessed this season ... , According to the American College of Foot and Ankle Surgeons, ...
... Calif., Nov. 18 IPC The Hospitalist Company (Nasdaq: ... of New London (HINL), based in New London, Connecticut, and ... The acquisition of these two practices marks IPC,s expansion into ... The two practices combined have approximately 55,000 patient encounters annually. ...
... improves exercise capacity in patients with enlarged hearts , ... keep their hearts healthy, new research shows. , The study ... such as diabetes or high blood pressure -- who were ... weekly physical activity for the previous 15 to 25 years. ...
... ... of the game," but players who sustain a series of even small head bumps may be ... ... blows as "part of the game." But players who sustain a series of even small head ...
... Medical Center (BIDMC) neurologists Alvaro Pascual-Leone, MD, PhD, and ... than $1.5 million from the Michael J. Fox Foundation ... improving the quality of life for patients with Parkinson,s ... system that affects one in 100 individuals over age ...
Cached Medicine News:Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 2Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 3Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 4Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 5Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 6Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 7Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 8Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 9Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 10Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 11Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 12Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 13Health News:Cyberonics Reports Record Sales and Operating Profit in Fiscal 2010 Second Quarter 14Health News:Healthy Feet Make the Best Dancing Feet 2Health News:IPC The Hospitalist Company Acquires Two New England Practices 2Health News:Lifelong Exercise Keeps Seniors Young at Heart 2Health News:Throw a Yellow Flag on Football-related Head Injuries, Warns the Harvard Mental Health Letter 2Health News:BIDMC scientists awarded grants from Michael J. Fox Foundation for Parkinson's research 2
(Date:4/30/2015)... Calif. , April 30, 2015  Accuray ... it has signed an agreement with MIM Software ... the TomoTherapy ® and CyberKnife ® product ... Accuray and MIM technology. This is Accuray,s second ... the development of the first iPad-based treatment plan ...
(Date:4/30/2015)... , April 30, 2015  Thoratec Corporation (NASDAQ: ... therapies to save, support and restore failing hearts, said ... Merrill Lynch 2015 Healthcare Conference on Thursday, May 14. ... Chief Executive Officer, will provide an update on the ... p.m., Eastern Daylight Time). The presentation will ...
(Date:4/30/2015)... 2015  DURECT Corporation (Nasdaq: DRRX ) announced ...  Total revenues were $4.8 million and net loss was ... 2015 as compared to total revenues of $6.3 million ... months ended March 31, 2014.At March 31, 2015, we ... cash and investments of $34.9 million at December 31, ...
Breaking Medicine Technology:Accuray Signs Agreement with MIM Software Inc. to Develop Adaptive Therapy Software 2Accuray Signs Agreement with MIM Software Inc. to Develop Adaptive Therapy Software 3Thoratec Presentation At Bank Of America Merrill Lynch Healthcare Conference To Be Webcast 2DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 2DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 3DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 4DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 5DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 6DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 7DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 8DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 9
... /PRNewswire/ -- Argus Health Systems, Inc., a ... with Walmart to provide expanded network services. This Preferred ... provide the lowest prescription benefit cost to Argus customers. ... customers a more cost-effective pharmacy network alternative. Access to ...
... Sept. 22, 2011 Watson Pharmaceuticals, Inc. (NYSE: ... and Sandoz Inc. have filed suit against Amphastar Pharmaceuticals, ... United States District Court for the District of Massachusetts. ... which Watson has the exclusive right to distribute in ...
Cached Medicine Technology:Argus Announces Retail Network Relationship 2Watson Confirms Amphastar Patent Lawsuit 2Watson Confirms Amphastar Patent Lawsuit 3
This aron protects at 0.5 mm Pb equivalency and is 20% lighter than our Standard Back-Aid Apron - yet it contains no lead products that can be harmful to the environment!...
Crisscross shoulder design facilitates better posture and distributes weight to back and hips for greater comfort. Shoulder pads soften shoulder contact with apron for additional comfort....
Use this workhorse apron where 360 of protection from direct and scatter radiation is required....
... Our popular Back-Aid Apron now ... Universal Back-Saver Belt that has ... more weight off your shoulders! ... strap redistribute weight from the ...
Medicine Products: