Navigation Links
Bioengineering production strains - Microbia develops new methods

The recently published issue of Nature Biotechnology outlines a new method developed by Microbia Ltd.'s scientists for rapidly identifying genes required for the production of industrial molecules produced in microbes. This is an advancement in the company's ability to improve the properties// of microbial cells for biomanufacturing pharmaceuticals and fine chemicals. This new technology enables the illumination of the best route to optimize a cell's metabolic potential to increase productivity and yield of drugs and chemicals manufactured at industrial scale.

Microbia's Senior Director for Biomanufacturing Business Development, Richard Bailey, said that the scientists at Microbia had used a systems approach to engineer the microbial circuitry that regulates metabolite production. He added that the scientists had illustrated how they develop the roadmap for these regulatory networks and once they pinpointed the key genes to be modulated, such as those contributing to high productivity, they will be able to selectively alter them to boost yields and improve other production parameters.

The Nature Biotechnology authors constructed genomic fragment microarrays for Aspergillus terreus and then utilized these arrays for transcriptional profiling of strains engineered to produce varying levels of lovastatin-a drug used widely to treat high cholesterol. By integrating transcriptional and metabolite data, the authors elucidated the key genetic components and critical regulatory nodes affecting lovastatin production.

The technology described is a component of Microbia's Precision Engineering approach to biomanufacturing process improvement. Precision Engineering provides a rapid and comprehensive alternative to traditional metabolic engineering methods by targeting the physiological control networks in fungal and bacterial cells.


'"/>




Page: 1

Related medicine news :

1. Digestive acid production dependent on newly found hormone
2. Roche confirms Tamiflu production talks in US
3. Pigs have another utility: production of healthy oils!
4. WHO takes initiative to fight corruption tainted medicine production-supply chain
5. African HIV strains more resistant to anti HIV drugs
6. E. coli strains resistant to a common antibiotic
7. Hormone restrains appetite in man
8. Fluorescent markers to distinguish Trypanosoma brucei strains causing Sleeping Sickness
9. Detection of Weak strains of bird flu virus – Target of European Unio
10. Resistant Influenza strains creates panic in US
11. Multiple infectious disease strains can coexist
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... , ... October 13, 2017 , ... Lori R. Somekh, ... member of ElderCounsel, a national organization of elder law and special needs planning attorneys. ... and rules. It also provides a forum to network with elder law attorneys nationwide,” ...
(Date:10/13/2017)... ... 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought ... This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at ... towards children of all ages; it is a non-competitive, non-timed event, which is all ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the loss ... author, William Nowers. Captain Nowers and his wife, Millie, have six children, ten ... the Navy. Following his career as a naval aviator and carrier pilot, he ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( ... today the introduction of an innovative new design of the shoulder pad. The ... get maximum comfort while controlling your pain while using cold therapy. By utilizing ice ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a ... of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners ... October 11, 2017. , The annual award competition recognizes editorial and design excellence across ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... , Sept. 25, 2017   Montrium , ... File solutions, today—from the IQPC Trial Master Files ... , NL)—announced that EastHORN Clinical Services has selected ... programs and TMF management. EastHORN, a leading European ... platform to increase transparency to enable greater collaboration ...
(Date:9/22/2017)... , Sept. 22, 2017  As the latest Obamacare ... Bill Cassidy (R-LA) and Lindsey Graham ... that the medical device industry is in an odd ... tax, the 2.3% excise tax on medical device sales ... also want covered patients, increased visits and hospital customers ...
(Date:9/19/2017)... , Sept. 19, 2017   ZirMed Inc ., a ... today announced that it has been ranked #1 by its ... Book™ Rankings 2017 User Survey. ZirMed was recognized as ... large hospitals and medical centers over 200 beds and holds ... healthcare technology user survey history. ...
Breaking Medicine Technology: