Navigation Links
Bioengineering production strains - Microbia develops new methods

The recently published issue of Nature Biotechnology outlines a new method developed by Microbia Ltd.'s scientists for rapidly identifying genes required for the production of industrial molecules produced in microbes. This is an advancement in the company's ability to improve the properties// of microbial cells for biomanufacturing pharmaceuticals and fine chemicals. This new technology enables the illumination of the best route to optimize a cell's metabolic potential to increase productivity and yield of drugs and chemicals manufactured at industrial scale.

Microbia's Senior Director for Biomanufacturing Business Development, Richard Bailey, said that the scientists at Microbia had used a systems approach to engineer the microbial circuitry that regulates metabolite production. He added that the scientists had illustrated how they develop the roadmap for these regulatory networks and once they pinpointed the key genes to be modulated, such as those contributing to high productivity, they will be able to selectively alter them to boost yields and improve other production parameters.

The Nature Biotechnology authors constructed genomic fragment microarrays for Aspergillus terreus and then utilized these arrays for transcriptional profiling of strains engineered to produce varying levels of lovastatin-a drug used widely to treat high cholesterol. By integrating transcriptional and metabolite data, the authors elucidated the key genetic components and critical regulatory nodes affecting lovastatin production.

The technology described is a component of Microbia's Precision Engineering approach to biomanufacturing process improvement. Precision Engineering provides a rapid and comprehensive alternative to traditional metabolic engineering methods by targeting the physiological control networks in fungal and bacterial cells.


Page: 1

Related medicine news :

1. Digestive acid production dependent on newly found hormone
2. Roche confirms Tamiflu production talks in US
3. Pigs have another utility: production of healthy oils!
4. WHO takes initiative to fight corruption tainted medicine production-supply chain
5. African HIV strains more resistant to anti HIV drugs
6. E. coli strains resistant to a common antibiotic
7. Hormone restrains appetite in man
8. Fluorescent markers to distinguish Trypanosoma brucei strains causing Sleeping Sickness
9. Detection of Weak strains of bird flu virus – Target of European Unio
10. Resistant Influenza strains creates panic in US
11. Multiple infectious disease strains can coexist
Post Your Comments:

(Date:11/30/2015)... ... November 30, 2015 , ... Insightra Medical, Inc. and Novus ... technology for soft tissue repair in the US via Insightra’s national direct sales ... mesh intended to support and reinforce soft tissue for 6-9 months before absorbing ...
(Date:11/30/2015)... ... 30, 2015 , ... SIMmersion’s ability to present dynamic scenarios ... of the future. To reach an audience of key visionaries and reformers in ... Chicago, organized by the American Medical Association. , AMA President Steven Stack, ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... enterprise Time and Attendance/Workforce Management cloud-based solutions, announced today that it has ... competencies in the Application Development, demonstrating a “best-in-class” ability and commitment to ...
(Date:11/30/2015)... November 30, 2015 (PRWEB) , ... ... ... and Winscribe are pleased to announce their strategic partnership at the Radiological ... consultants, SpeechCheck, Inc., and Winscribe, global providers of cutting-edge dictation and speech-enabled ...
(Date:11/30/2015)... ... 30, 2015 , ... World Patent Marketing , a ... household invention that provides an economical and easy way of gaining customized curtains. ... at 2.6%," says Scott Cooper, CEO and Creative Director of World Patent Marketing. ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 /PRNewswire/ ... --> adds "Global ... and "Investigation Report on China Repaglinide ... 2021 forecasts data and information to ... . --> ...
(Date:11/26/2015)... , Nov. 26, 2015 Research and ... of the "2016 Future Horizons and Growth ... Market: Supplier Shares, Country Segment Forecasts, Competitive Intelligence, ... --> --> ... of the Italian therapeutic drug monitoring market, including ...
(Date:11/26/2015)... November 26, 2015 ... addition of the  "2016 Future Horizons ... Cell Surface Marker Testing Market: Supplier ... to their offering.  --> ... of the  "2016 Future Horizons and ...
Breaking Medicine Technology: