( In four years 50 million American wome...)Bio-Identical Hormone Replacement Therapy,Health

In four years, 50 million American women will be in menopause. The federal government’s decision in 2002 to suspend the use of synthetic hormone replacement// therapy (HRT) in a large scale clinic trial of the effects of HRT, left many women and physicians uncertain about the safety of synthetic hormones and searching for alternatives.

Bio-identical (“natural”) hormone replacement therapy (nBHRT) has been proposed by some doctors as a reasonable alternative, although it is not commonly prescribed. nBHRT, like its synthetic counterpart, requires a physician’s prescription for the hormones estrogen and progesterone. The hormones differ in that nBHRT is derived from plants rather than synthetic chemicals. They also differ in that the synthetic formulations are manufactured by pharmaceutical companies and packaged into specific, standard doses. Conversely, nBHRT is prescribed in person-specific doses and compounded (i.e., assembled) by a pharmacist.

In a release issued last October, the American College of Obstetricians and Gynecologists (ACOG) stated that there was “no scientific evidence to support claims of increased efficacy or safety for individualized estrogen or progesterone regimens prepared by compounding pharmacies.” It also noted the “lack of well-designed and well-conducted clinical trials of these compounded hormones.”

Methodology To assess the efficacy of nBHRT treatment of estrogen deficiency symptoms, progesterone-related symptoms, and the effects of hypothyroidism, 50 perimenopausal/menopausal women (PMPW) with low concentrations of progesterone and estradiol (blood and salivary tests), a body mass index (BMI)> 24, a low basal body temperature (<98.2) and menopausal symptoms volunteered to be included in a time-sequenced cohort. Women who had had surgical menopause, a history of long-term clinical depression, were taking synthetic ovarian hormones or who had had any estrogen-related cancers were excluded.


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