Navigation Links
Beta Agonists May Alter the Immune System

New research at Wake Forest University School of Medicine suggests that certain inhaled asthma medications – as well as similar chemicals our bodies produce during times of high stress – may worsen diseases such as asthma // , heart failure and lupus that involve inflammation.

The scientific team led by Raymond Penn, Ph.D., and Matthew Loza, Ph.D, found that beta-agonists, such as those used in the treatment of asthma, increase the accumulation of type 2 T cells, a type of white blood cell that participates in immune system defense mechanisms. In certain diseases such as asthma and lupus, an over-reactive type 2 T cell response occurs and is believed to contribute to the disease.

“Inhaled beta-agonists are very effective in opening up airways and allowing asthmatics to breathe, but their ability to address the underlying inflammation that causes most asthma has been debated for years,” said Penn, an associate professor in the Department of Internal Medicine and the Center for Human Genomics.

The research is reported on-line in the Journal of Allergy and Clinical Immunology and will be published in an upcoming print issue.

In fact, numerous clinical studies have reported that asthma symptoms tend to worsen over time in patients on continuous beta-agonist therapy. Although the reasons for this deterioration of asthma control are not clear, the Food and Drug Administration now recommends that the treatment of asthma with long-acting beta-agonists be supplemented with inhaled anti-inflammatory medications.

Using blood samples from human participants, the scientists measured the effect of beta-agonists on white blood cells that were grown in the laboratory. They were surprised to find that the drugs promoted a preferential accumulation of type 2 T cells.

Beta-agonists belong to a class of chemicals that include the hormone adrenaline produced by the body. Consequently, conditions that elevate blood ad renaline, such as emotional stress or heart failure, may also have the ability to alter the immune system by increasing type 2 T cells, and thereby promote or worsen disease.

“Although further research is needed to confirm that these findings occur in the human body, our research points to an important means by which the immune system is regulated by both therapies and the hormonal system,” Penn said. “From an asthma management standpoint, these studies further emphasize the need to include anti-inflammatory corticosteroids when treating moderate to severe asthma.”

The researchers also uncovered the mechanism which by beta-agonists increased type 2 T cells. They found that the beta-agonists were unable to effectively stimulate the enzyme protein kinase A (PKA). Other molecules similar to beta-agonists that were able to strongly activate PKA also inhibited the ability of type 2 T cells to proliferate and survive. Penn said this finding could influence future drug development, because new beta agonists that are more effective in activating PKA may prove useful.

Source-NewswiseBR>SRM
'"/>




Related medicine news :

1. Prince Charles lends support to Alternative Medicine
2. Alternative medicine more popular among HIV positive patients
3. Complementary and Alternative medicine
4. Alternative therapies popular with Parkinsons patients
5. Altering genes through calories
6. Alternative to blood Transfusions
7. Alternative Therapy in HIV Patients
8. An Alternative to Warfarin
9. Another Alternative For Diabetics On Insulin
10. The Use Of Alternative Medicine On The Rise
11. Heart Patients Use Alternative Medicine
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2017)... ... June 24, 2017 , ... Studies show evidence that carotenoids ... risk of visual loss in these patients. , But how often do ophthalmologists and ... cessation to patients at risk of or with early symptoms of AMD? A ...
(Date:6/23/2017)... ... 23, 2017 , ... Goodcents Deli Fresh Subs today announced the opening of ... SW 21st St. Topeka, Kan. 66604 (near 21st and Gage). It is owned and ... three other locations in the Topeka and Bonner Springs, Kan. area. , “Goodcents ...
(Date:6/23/2017)... Palm Beach, FL (PRWEB) , ... June 23, 2017 , ... ... 19, in Pinecrest, Florida. This is MD Now’s 28th facility overall and marks the ... S. Dixie Highway, located one mile North of The Falls shopping mall. The new ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Katyl Agency, a ... families and business owners in and around Lackawanna County, is joining Meals On ... the area. , Meals on Wheels of NEPA provides hand-delivered and nutritious meals ...
(Date:6/22/2017)... , ... June 22, 2017 , ... Branches, Inc. has ... than $245,000 in grant funding to support its programs focused on providing opportunity to ... was awarded a grant by the Foundation of $15,000 to support its , Climb ...
Breaking Medicine News(10 mins):
(Date:5/30/2017)... , May 30, 2017 Hill-Rom Holdings, Inc. (NYSE: ... Annual Global Healthcare Conference on Tuesday, June 13, 2017, in ... Greisch , Hill-Rom,s president and chief executive officer, is scheduled ... live audio webcast can be accessed at http://ir.hill-rom.com/events.cfm . ... of the live event through September 13, 2017. ...
(Date:5/29/2017)... TEL AVIV, Israel, May 29, 2017  Cellect Biotechnology ... of innovative technology which enables the functional selection of ... financial results for the first quarter ended March 31 ... pleased with our accomplishments in the first quarter of ... the first quarter, we announced the treatment of the ...
(Date:5/26/2017)... BARBARA, Calif. , May 25, 2017  In ... United States , Direct Relief is working with ... overdose-reversing Naloxone available at no cost to community health ... other nonprofit providers nationwide. "Pfizer has ... access to medicines and ensuring patient safety through educational ...
Breaking Medicine Technology: