Navigation Links
Benefits of ADT Against Risk of Heart Ailments

Androgen deprivation therapy may aggravate heart disease in patients over age 65, according to a new study by researchers at Dana-Farber Cancer Institute. //

ADT is one of the most common treatments for prostate cancer.

The study results were based on data from CaPSURE, a national registry of men with prostate cancer. Although the findings need to be confirmed in clinical trials, the study authors state that oncologists should weigh the benefits of androgen deprivation therapy, or ADT, against the risk of heart problems in older prostate cancer patients.

The researchers will present their study at the Prostate Cancer Symposium in Orlando, Fla., 1:30 pm on Saturday, Feb. 24. The symposium is sponsored by the American Society of Clinical Oncology, the American Society for Therapeutic Radiology and Oncology and the Society of Urologic Oncology.

The goal of ADT is to block the level of circulating androgens (male hormones), which can fuel the growth of prostate cancers. "Androgen deprivation therapy is associated with elevated body mass index, increased body fat deposits and diabetes, all of which raise the risk of death from heart diseased," explains the study's lead author, Henry Tsai, MD, a resident physician at Dana-Farber, Brigham and Women's and the Harvard Radiation Oncology Program.

"Although our findings demonstrated that older men receiving this treatment may be at increased risk, even after taking into account other cardiovascular risk factors, a prospective clinical trial would be needed to confirm a cause-and-effect relationship."

Drawing on the CaPSURE database, Tsai and his colleagues compared the number of cardiac-related deaths among 735 men with localized prostate cancer who received ADT and among 2,901 men with the disease whose treatment did not include ADT.

After factoring in other known risks for cardiovascular disease (such as diabetes, hypertension, body mass ind ex and smoking), researchers found that the longer patients received ADT, the sooner they were likely to die from heart disease.

When the researchers analyzed the data by patients' age, the link between ADT use and death from heart disease was significant in patients over age 65, but not in those under 65. After five years, 3 percent of older men who received androgen deprivation therapy died of cardiac causes, compared with only 0.9 percent of men who did not receive the therapy.

"These findings should help oncologists determine which older patients are the best candidates for ADT," Tsai remarks. "If a patient is at high risk of cardiovascular disease, it would be advisable for an oncologist to discuss the pros and cons of ADT treatment with him before proceeding on a course of treatment."

Source-Eurekalert
PRI
'"/>




Related medicine news :

1. Benefits in fertility procedures
2. Benefits of Vitamin Supplements Unclear
3. Benefits of Eating Whole Grains, Fruits and Vegetables
4. Benefits of Nitric Oxide in the Treatment of Premature Infants
5. Benefits and Risks of Asthma Treatment Questioned
6. Benefits Of The Worlds Most Widely Used Beverage
7. Drug In Asthma inhaler Found To Counteract Benefits
8. The Benefits Of Keyhole Surgery
9. The Benefits Of A Stretch
10. A Reduction In Calories Found To Yield More Benefits
11. The Benefits Of Soy
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... ... March 28, 2017 , ... City trips have soared 82% ... Trends Report). As travelers visit both urban destinations, they are faced with exploration ... exposure. In response, the outdoor industry has blurred the lines between fashion and ...
(Date:3/28/2017)... ... 2017 , ... Z-Medica, LLC, a leading developer and marketer ... will acquire QuikClot® Bleeding Control Kits® (BCK) to equip up to 1,000 schools ... by the American College of Surgeons, U.S. Department of Defense, Department of Homeland ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... Paul Yost, will begin serving as new board chair for Orange County health ... will serve the remainder of soon-to-be former chair Mark Refowitz’s term, which runs ...
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... ... health plans work, the Self-Funding Success website has recently developed and published an ... Health Plans ” was created based on common inquiries the site’s team of ...
(Date:3/28/2017)... ... March 28, 2017 , ... Prominant bariatric surgeon and ... thrilled to offer the recently FDA-approved Obalon Balloon System to his patients. The ... Advanced Surgical’s already comprehensive list of weight-loss services. Dr. Liu is proud ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... , March 27, 2017 ... specialty clinical-stage pharmaceutical company specializing in the development of ... public offering in the United States ... each ADS representing 40 ordinary shares of the ... In addition, Therapix has granted the underwriters a ...
(Date:3/27/2017)...  Cryoport, Inc. (NASDAQ: CYRX, CYRXW) ("Cryoport" or the ... of common stock in an underwritten public offering under ... Securities and Exchange Commission (the "SEC"). The offering is ... be no assurance as to whether or when the ... size or terms of the offering. Cryoport also expects ...
(Date:3/27/2017)... 2017 To mark the end of Save Your ... leader in digital imaging solutions, will showcase Canon eye care ... New York,s Jacob Javits Center from ... sponsored by the American Optometric Association, is observed annually in ... comprehensive eye exams. In recognition of this observance, Canon ...
Breaking Medicine Technology: