Navigation Links
Basis for Nerve fiber Damage in Multiple Sclerosis Discovered

Researchers have discovered the main culprit for nerve fibre damage in multiple sclerosis, which is triggered by the body's own immune system, which is vital for early diagnosis // and evolving improved treatment of a severe disease. The study indicated the manner in which immune system B-cells damage axons in the course of MS attacks by hampering the energy production in nerve fiber cells, ultimately bringing about natural death of these cells. Study is published in the Oct. 15 issue of the Journal of Immunology.

B-cell-axon activity is an emerging area of MS research, one that is changing how scientists and clinicians can look at this disease. In this study, Dr. Yufen Qin and fellow researchers from UC Irvine's School of Medicine analyzed spinal fluid and tissue samples from MS patients to identify substances that stimulate a B-cell immune response. They noted an increased level of B-cell antibodies on lesions and in spinal fluid bound to two specific enzymes – GAPDH and TPI.

These two enzymes are essential for efficient energy production. The researchers believe that the binding of these antibodies to these enzymes – GAPDH, in particular – may lower the amounts of ATP – the chemical fuel for cells – available in cells, which eventually can lead to axon cell degeneration and death. In addition to the energy-production function, GAPDH is involved with a number of genetic activities, such as RNA translocation, DNA replication and DNA repair.

Other recent studies have shown that binding of inhibitors to GAPDH and TPI causes decreased ATP production in neurons, followed by progressive neuronal degeneration and death. Moreover, patients with TPI deficiency can develop progressive neurological disorders.

"This research is exciting and potentially important for future treatments because it identifies new antibodies associated with MS that can be targeted with emerging therapies," said Qin, an assistant professor of neurology. "Signific
'"/>




Page: 1 2 3

Related medicine news :

1. Genetics Might BE The Basis For Chronic Fatigue Syndrome
2. Molecular Basis Of ALS Found
3. Biological Basis for Homosexuality
4. Biological Basis Behind a Couch Potato
5. Researchers Develop Basis For Experimental Melanoma Treatment
6. Researchers Investigate Molecular Basis of Memory
7. Epilepsy Drug Helps Diabetic Nerve Damage
8. World’s First Nerve Stem Cells Produced
9. Children With Epilepsy Can Be Treated With Nerve Stimulation
10. FDA Approved Nerve-Stimulation Therapy Now Available In New York
11. Doctors Finish Mother-To-Son Nerve Surgery
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Basis for Nerve fiber Damage Multiple Sclerosis Discovered

(Date:9/1/2014)... Wellesley, Mass., (PRWEB) September 01, 2014 ... report, BLOOD-BRAIN BARRIER TECHNOLOGIES AND GLOBAL MARKETS ... reached $21.8 million in 2013 and is expected to ... further grow to $471.5 million by 2019, which is ... 2014 through 2019. The receptor-mediated transport (RMT) segment is ...
(Date:9/1/2014)... September 01, 2014 Registration is now open ... 5K and 1-Mile Race to be held on Sunday, September ... Court Yard at Harmon Meadow in Secaucus, New Jersey. All ... a national nonprofit dedicated to restoring a sense of self, ... members and our military families. , General registration is $30 ...
(Date:9/1/2014)... The Outlier Series announced the next short ... from one of the exceptional women featured in the ... Changers . The title of the upcoming mini e-Book ... McClendon . McClendon is currently a full-time physician’s assistant, ... of WeTV show, Raising Sextuplets. , Jenny was chosen ...
(Date:9/1/2014)... 2014 Beginning Tuesday, September 2nd, Las ... professionals and 10,000 consumers for the annual gathering known ... of the nation’s top medical professionals who specializes in ... The week-long event contains more than 120 hours of ... in the pain management field. , MarijuanaDoctors.com is pleased ...
(Date:8/31/2014)... 31, 2014 MYMOBILEUNI (MMU) strategy ... social media marketing tools access to digital, resources, ... will utilize all tools to reach and collaborate ... our multiple learning channels. , MMU, today announced ... an authoring tool that applies social networking concepts ...
Breaking Medicine News(10 mins):Health News:Global Market for Blood-Brain Barrier (BBB) Technology to Reach $471.5 Million in 2019; Highest CAGR Growth in Latin American Market With 10.5% 2Health News:Global Market for Blood-Brain Barrier (BBB) Technology to Reach $471.5 Million in 2019; Highest CAGR Growth in Latin American Market With 10.5% 3Health News:Hope For The Warriors New Jersey Run to Honor Wounded and Families of the Fallen 2Health News:Upcoming Outlier Series eBook about Jenny McClendon, PA-C, Former Start of Raising Sextuplets 2Health News:Upcoming Outlier Series eBook about Jenny McClendon, PA-C, Former Start of Raising Sextuplets 3Health News:Medical Marijuana Doctor Company Set to Present at Las Vegas Pain Week 2Health News:My Mobile University Announces Global Strategic Plan and Unveils New Android App to Enhance and Impact Lives World-Wide Through Education for All as Learning Platform 2Health News:My Mobile University Announces Global Strategic Plan and Unveils New Android App to Enhance and Impact Lives World-Wide Through Education for All as Learning Platform 3
... have some beneficial effects in fighting cancer, new research ... potential to perform better with this ingredient//. ,Vaccines work ... tissues and destroy them. But often, the immune system ... the healthy ones. ,But researchers at University ...
... Court would pass judgment regarding an appeal by health officials, ... a 17-month-old boy die//. Lawyers who are currently handling the ... of life is so poor and that doctors should be ... the boy and the treating physicians have not been revealed ...
... researchers said that mammograms were able to detect non ... Some previous studies// show that 54% of the mammograms ... rate is about 1% only. But the present study ... ,Dr. Sophia Zackrisson, a radiologist from the Epidemiological Research ...
... Center have zoned in on new molecular indicators, called ... be an interesting pointer when evaluating anti-aging therapies. The ... latest issue of the Journal of Investigative Dermatology. ... and cosmetic industries in developing products that will minimize ...
... who use the Internet more frequently are found to ... and social lives. Studies also suggested// that there is ... ,The Rotterdam-based Institute for Research into Lifestyles and Addiction ... 15 and found that what it termed "compulsive internet ...
... recent mental health study conducted by Dr. Michelle Hindin ... their parents are at an increased risk// of developing ... the respondents reported witnessing parental domestic violence. ... 5 female adolescents wished that they had died in ...
Cached Medicine News:Health News:Life Or Death: Parents Await High Court Judgment 2Health News:Mammograms Detect Non Progressive Cancer 2Health News:Biomarkers Could Prove Significant In Understanding Aging Process 2
(Date:8/29/2014)... Aug. 29, 2014  United Therapeutics Corporation (NASDAQ: ... Court for the District of New Jersey ... company,s case against Sandoz, Inc. regarding United Therapeutics, Remodulin ... ruled that U.S. Patent No. 6,765,117 is both ... from marketing its generic product until the expiration of ...
(Date:8/29/2014)... 29, 2014 According to ... & Services (Equipment, Reagent, Primer, Probe, Custom Oligos), ... QPCR, Gene Synthesis, NGS, DNA, RNAi) - Global ... Oligonucleotide Synthesis Market is expected to reach $1,712.1 ... growing at a CAGR of 9.8% from 2014 ...
(Date:8/29/2014)... YORK, Pa. , Aug. 29, 2014  Unilife ...  ASX: UNS) announced today that it intends to release ... and year ended June 30, 2014 after market trading ... Management has scheduled a conference call for 4:30 p.m. ... 10, 2014 at 6:30 a.m. AEST), to review the Company,s ...
Breaking Medicine Technology:District Court Decision Received In Remodulin Patent Case 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 3Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 4Unilife Corporation to Announce Financial Results for Fiscal Year 2014 Fourth Quarter and Year End on Tuesday, September 9, 2014 2
... CINCINNATI, July 7 Procter & Gamble Pharmaceuticals (P&GP) ... tablets, which are indicated for the treatment of moderately ... disease. UC involves inflammation of the lining of the ... followed by periods of remission. Moderately active UC is ...
... Tenn., July 6 /PRNewswire/ -- A Pebble Beach ... cure for multiple sclerosis. The researchers took home the top ... and the non-profit Band Against MS (BAMS) organization. The money ... at the University of Texas Health Science Center at ...
Cached Medicine Technology:Procter & Gamble Pharmaceuticals Launches Asacol(R) HD (mesalamine) Delayed-Release Tablets 2Procter & Gamble Pharmaceuticals Launches Asacol(R) HD (mesalamine) Delayed-Release Tablets 3Procter & Gamble Pharmaceuticals Launches Asacol(R) HD (mesalamine) Delayed-Release Tablets 4Procter & Gamble Pharmaceuticals Launches Asacol(R) HD (mesalamine) Delayed-Release Tablets 5Clay Walker's Band Against MS Foundation Donates $150,000 To Support Multiple Sclerosis Research 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: