Navigation Links
Bad Enzymes Found To Enable Brain Recovery Following Stroke

The same enzymes that cause brain damage following an acute attack of stroke could be beneficial some time later. This finding perhaps highlights that effective treatment // of stroke could be possible if administered few weeks following the stroke, instead of the treatment within couple of hours following stroke. Additionally, it could open avenues for the development of novel stroke treatment strategies and new generation drugs in treating the same.

The enzyme matrix metalloproteinase-9 (MMP-9) has been found to help in remodeling of the brain 14 days following stroke, in experiments conducted on animal mouse models by Harvard medical school researchers. The results of the study can be found in April issue of the Nature Medicine journal.

The enzymes serve to breakdown the complex structure that surrounds the cells, known as the extracellular matrix. The compound has been found to result in growth of new blood vessel in the damaged brain region. In addition it induces cell growth, cell differentiation and movement of the cells.

Stroke occurs due to a temporary loss of blood supply to the brain. This can occur either due to blockage of a blood vessel though blood clot or rupture of a blood vessel, supplying the brain. Following stroke, MMPs eat away the damaged brain tissue, increasing risk of inflammation and brain hemorrhage.

Current treat of stroke is directed at inhibiting the effect of these damage-causing MMPs. The only FDA-approved medication for the treatment of stroke is tissue plasminogen activator (tPA). This has to be administered with three hours of an acute stroke episode, to prevent irreversible damage to the brain.

Rats that were designed to mimic human models of stroke were given different doses of the MMP inhibitor, at different intervals. Administration of the inhibitor immediately following the stroke showed smaller brain damaged areas. No effect was observed when it was administered thr ee days following stroke. Extensive brain damage was seen when the inhibitor was given at 7 or 14 days after stroke.

Surprisingly, high levels of the MMPs were found adjacent to the damaged area, more specifically in the peri-infarct cortex, an area that enables recovery of the brain following stoke.

'We have mostly thought of MMPs as being bad. Our data strongly suggest that they play a totally different role during stroke recovery. The peri-infarct zone is very dynamic and potentially very malleable for long periods of time after stroke,' said Eng H. Lo, from the Neuroprotection Research Laboratory at Massachusetts General Hospital.

The researchers have however warned about the use of these compounds in stroke management, as the activity of the MMPs has to be regulated to ensure an optimal recovery of the stroke patient.


'"/>




Related medicine news :

1. Smoking Hazardous To The Enzymes System In Lungs
2. New Role of COX Enzymes Discovered
3. Immune System Gears Up by Specific Enzymes
4. Study Attributes Elevated Liver Enzymes in HIV/hepatitis to Coinfection Rather Than Antiretrovirals
5. Fluoride Found Effective in Osteoporosis
6. Implantable Contact Lens Found Safe and Effective
7. Cancer hazard Found With Animal-Based Nutrients
8. Processed Meat, Diabetes connection Found
9. Night Time Aspirin Regimen Found to Reduce Blood Pressure
10. Hydrotherapy Found to be Effective for Patients with Osteoarthritis
11. Hydrotherapy Found to be Effective for Patients with Osteoarthritis
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/23/2017)... , ... February 23, 2017 , ... HealthPostures, the desk ... an expert sit stand solutions representative to the Minneapolis Home and Garden Show which ... the event that is garnering national attention is the Minneapolis Convention Center. , ...
(Date:2/22/2017)... ... February 22, 2017 , ... Our ... to overwork even the sharpest brain. , Power On, a mental performance enhancer ... over clocking the brain. Each capsule contains Cognizin® Citicoline, a branded form of ...
(Date:2/22/2017)... ... February 22, 2017 , ... Secure ... to the largest network of hospitals, health information exchanges, physicians and patients, announced ... Information Technology (ONC-HIT) 2015 Edition Health IT Module Certification via Drummond Group LLC, ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... understand each Medicare Advantage member’s risk, identify any gaps-in-coding, as well as ... helps transform the HCC Risk Adjustment process from a typical fragmented process ...
(Date:2/22/2017)... ... February 22, 2017 , ... Sideline Products participated in the World Horse ... host Tom Seay and his production crew. Tom Seay’s program “Best of America ... world. Saddle Sidekicks will be featured on April 6, 2017. After the broadcast, ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... 22, 2017  Andre, DiMino, CEO of ADM Tronics ... of innovative technologies and products, commented on ADMT,s third ... 21, 2017 in the Company,s quarterly report on Form ... CEO Andre, DiMino stated "During the quarter ended December ... devoting a larger portion of our engineering efforts into ...
(Date:2/22/2017)... Feb. 22, 2017  Ultra Clean Holdings, Inc. ... critical systems and subsystems for the semiconductor capital ... today reported its financial results for the fourth ... "2016 was a year of extraordinary ... reached record highs and together with continued focus ...
(Date:2/22/2017)... Feb. 22, 2017 Summary Provides ... and agreements entered into by the worlds leading healthcare ... Description The Global Spinal Cord Partnering Terms and ... partnering deals and agreements entered into by the world,s ... deals - Top deals by value - ...
Breaking Medicine Technology: