Normally we want to avoid having bacteria in our eyes, urethras, and spinal columns, but researchers at Carnegie Mellon University would like to change that.// They have figured out how to glue S. marcescens to micro-robots for the delivery of drugs to hard to reach areas of the body.
One of the main challenges in developing microscale robots lies in miniaturising their power and propulsion. Now, researchers in the US may have found a solution to this problem, by exploiting the natural movement of bacteria to propel micro-objects through water.
Many bacteria propel themselves along in a fluid by rotating their corkscrew-like tails, called flagella, at relatively high speeds. These flagella are only around 20 nanometres in diameter and are about 10,000 nm long.
Motors made from bacterial flagella have been used as novel "nano-actuators" before, but Metin Sitti and Bahareh Behkam of Carnegie Mellon University in Pennsylvania, US, have taken another approach. They use the entire microorganism as the motor and control its on/off motion with chemicals.
Sitti and Behkam began by sticking several S. marcescens - the kind of bacteria that cause pink stains on shower curtains - onto polystyrene beads 10 microns in diameter. These tiny "robots" were suspended in a solution containing water and glucose.
The bacteria themselves are only about one-fifth of the size of each bead and adhere to them via electrostatic, van der Waals forces and hydrophobic interactions. As the attached bacteria rotate their flagella, feeding on surrounding glucose, they push their bead forward at speeds of around 15 microns per second.
To stop the bacteria's motion, the researchers add copper sulphate to the solution. The copper ions bond to the rotor of the flagella motor and prevent it from moving. To restart the motion, another chemical called ethylenediaminetetraacetic acid (EDTA) is added. The EDTA traps the copper ions attached to thPage: 1 2 Related medicine news :1
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