Navigation Links
Bacteria Fighter Goes Where Antibiotics Can't

Researchers at the Technion-Israel Institute of Technology have figured out a way to turn one of nature’s most powerful microbe //fighters into a guided missile that strikes specifically at a common bacteria responsible for serious infections throughout the body.

Professor Amram Mor of the Biotechnology and Food Engineering Faculty and his colleagues revamped an antimicrobial peptide, a small molecule made of short chains of amino acids that attacks Pseudomonas aeruginosa.

P aeruginosa is the bacterium behind serious lung infections in people with cystic fibrosis and some types of pneumonia and meningitis, as well as less serious but widespread infections such as “swimmer’s ear” and urinary tract infections.

The research was reported in the January 26 issue of the journal Chemistry and Biology. Common antibiotic medicines used to treat infections are increasingly thwarted by new strains of drug-resistant bacteria. Unlike most antibiotics, antimicrobial peptides can sidestep such resistance mechanisms and destroy by brute force, often simply ripping a hole in a targeted cell. For this reason, “antimicrobial peptides present an obvious advantage over conventional antibiotics,” said Mor.

Yet one of the features that makes the peptides so useful—their ability to kill a variety of invaders from bacteria to cancer cells—makes them hard to deploy as a treatment against specific infections. Their “non-specific” action can also destroy normal red blood cells.

The number and order of amino acids in an antimicrobial peptide determines how it recognizes and attacks an invading microbe. Some previous studies have shown that removing amino acids from one end of a peptide can boost its antibacterial properties. However, these shortened peptides are also more deadly to red blood cells.

To build a more useful and less toxic antimicrobial peptide, Mor and colleagues removed a few amino acids from one end of a dermaseptin peptide and replaced it with a fatty acid molecule. (Dermaseptins are a well-known family of peptides that destroy a wide range of microbes). The study shows for the first time that a fatty acid can replace part of a shortened peptide, which may lower the costs of manufacturing such peptides, according to the researchers.

The change made this particular peptide deadly accurate against P. aeruginosa while leaving other bacteria alone. The new peptide was also 60 times less likely to adhere to red blood cells.

“Many experts believe that one of the factors that might hamper the commercial use of antimicrobial peptides is their prohibitive cost. Therefore, smaller means cheaper and in this case, more potent,” Mor said.

Mor said the procedure might be used to create a variety of designer peptides that latch on different microbes, and that his lab will work on repeating the strategy with other peptide chains. The researchers also hope to test these new peptides against infections in animals.

Source-Newsise
SRI
'"/>




Related medicine news :

1. Bacterial discovery may help CF patients
2. Cure for Bacterial Meningitis
3. Before Weight Loss Surgery One Should Get Tested for Bacteria
4. Molecule That Aids Bacterial Infections Identified
5. Moms Stomach Bacteria Can Cause Leukaemia In Children
6. Bacteria Evolve Armamentarium Against Antibiotics By ‘Stealing’ Gens
7. Bacterial Photographs Created By Student Scientists!
8. Bacterial infestation in food very critical!
9. Tooth Decay Bacteria Unaffected By Altered Biochemical Pathway
10. Beneficial Symbiotic Relationship Between Ants And Bacteria.
11. Tamiflu substrate produced from Bioengineered Bacteria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/27/2016)... ... May 27, 2016 , ... An influential resource amongst nurses and professionals ... shed lights on the variety of topics detailing why we appreciate nurses in so ... this career has gone from being in a major recession to one of the ...
(Date:5/27/2016)... ... May 27, 2016 , ... An educational campaign ... inspiring human-interest stories, courtesy of awareness-driven celebrities and thought leaders. It also provides ... associations and industry leaders such as Bioness. , As patients feel increasingly ...
(Date:5/27/2016)... ... May 27, 2016 , ... ... is bolstered by inspiring human interest stories, courtesy of leaders in the nursing ... tech within the industry, from leading advocates and associations—namely Jones & Bartlett Learning. ...
(Date:5/27/2016)... ... May 27, 2016 , ... ... in the pharmaceutical, medical and food industries. Aside from its GMP accreditation, Validation ... providing proof of successfully certified products, services and staff. , Validation Center is ...
(Date:5/26/2016)... Hampshire (PRWEB) , ... May 26, 2016 , ... ... care products, has been honored with a 2016 When Work Works Award for its ... award, part of the national When Work Works project administered by the Families and ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... 25, 2016 As illustrated by ... this month, the numbers and momentum of cannabis in ... into the billions, more research and development push the ... State of Legal Marijuana Markets Report  from from ArcView ... much of the increase in sector is attributed to ...
(Date:5/25/2016)... Inivata, a global clinical ... tumour DNA (ctDNA) analysis to improve personalised healthcare ... Clive Morris as Chief Medical Officer. ... development programme, scientific collaborations, and through to commercialisation ... in clinical outcomes for patients. Clive ...
(Date:5/24/2016)... 24, 2016   ... primären Endpunkte und demonstriert Ebenbürtigkeit bei ... ‚ausgezeichneter plus guter , ...      (Logo: http://photos.prnewswire.com/prnh/20130829/633895-a ) ... positive Daten von der MORA-Studie der Phase III ...
Breaking Medicine Technology: