Navigation Links
Bacteria Fighter Goes Where Antibiotics Can't

Researchers at the Technion-Israel Institute of Technology have figured out a way to turn one of nature’s most powerful microbe //fighters into a guided missile that strikes specifically at a common bacteria responsible for serious infections throughout the body.

Professor Amram Mor of the Biotechnology and Food Engineering Faculty and his colleagues revamped an antimicrobial peptide, a small molecule made of short chains of amino acids that attacks Pseudomonas aeruginosa.

P aeruginosa is the bacterium behind serious lung infections in people with cystic fibrosis and some types of pneumonia and meningitis, as well as less serious but widespread infections such as “swimmer’s ear” and urinary tract infections.

The research was reported in the January 26 issue of the journal Chemistry and Biology. Common antibiotic medicines used to treat infections are increasingly thwarted by new strains of drug-resistant bacteria. Unlike most antibiotics, antimicrobial peptides can sidestep such resistance mechanisms and destroy by brute force, often simply ripping a hole in a targeted cell. For this reason, “antimicrobial peptides present an obvious advantage over conventional antibiotics,” said Mor.

Yet one of the features that makes the peptides so useful—their ability to kill a variety of invaders from bacteria to cancer cells—makes them hard to deploy as a treatment against specific infections. Their “non-specific” action can also destroy normal red blood cells.

The number and order of amino acids in an antimicrobial peptide determines how it recognizes and attacks an invading microbe. Some previous studies have shown that removing amino acids from one end of a peptide can boost its antibacterial properties. However, these shortened peptides are also more deadly to red blood cells.

To build a more useful and less toxic antimicrobial peptide, Mor and colleagues removed a few amino acids from one end of a dermaseptin peptide and replaced it with a fatty acid molecule. (Dermaseptins are a well-known family of peptides that destroy a wide range of microbes). The study shows for the first time that a fatty acid can replace part of a shortened peptide, which may lower the costs of manufacturing such peptides, according to the researchers.

The change made this particular peptide deadly accurate against P. aeruginosa while leaving other bacteria alone. The new peptide was also 60 times less likely to adhere to red blood cells.

“Many experts believe that one of the factors that might hamper the commercial use of antimicrobial peptides is their prohibitive cost. Therefore, smaller means cheaper and in this case, more potent,” Mor said.

Mor said the procedure might be used to create a variety of designer peptides that latch on different microbes, and that his lab will work on repeating the strategy with other peptide chains. The researchers also hope to test these new peptides against infections in animals.

Source-Newsise
SRI
'"/>




Related medicine news :

1. Bacterial discovery may help CF patients
2. Cure for Bacterial Meningitis
3. Before Weight Loss Surgery One Should Get Tested for Bacteria
4. Molecule That Aids Bacterial Infections Identified
5. Moms Stomach Bacteria Can Cause Leukaemia In Children
6. Bacteria Evolve Armamentarium Against Antibiotics By ‘Stealing’ Gens
7. Bacterial Photographs Created By Student Scientists!
8. Bacterial infestation in food very critical!
9. Tooth Decay Bacteria Unaffected By Altered Biochemical Pathway
10. Beneficial Symbiotic Relationship Between Ants And Bacteria.
11. Tamiflu substrate produced from Bioengineered Bacteria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/15/2017)... Viejo, California (PRWEB) , ... January 15, 2017 , ... ... a stylistic slideshow with complete customization and ease," said Christina Austin - CEO of ... of controls so that users can edit the style and animation of their slideshows. ...
(Date:1/15/2017)... ... 2017 , ... The Gravity Vault Indoor Rock Climbing Gym is excited to ... on the 14,000+ square foot climbing gym, the owners anticipate to open sometime in ... Jersey and two in New York. With this being its first location in Pennsylvania, ...
(Date:1/14/2017)... ... January 13, 2017 , ... ... incorporating a magnesium-rich Mediterranean diet may lower the risk of type 2 diabetes, ... that the many health and wellness benefits linked to a Mediterranean diet are ...
(Date:1/13/2017)... (PRWEB) , ... January 13, 2017 , ... ... that raise blood sugar levels. Counting carbohydrates is as easy as checking the ... only nutrient that affects blood sugar levels. Despite being sugar-free, proteins can influence ...
(Date:1/13/2017)... ... ... KOAMTAC ®, Inc., a leading manufacturer of Bluetooth barcode scanners and ... data collector at the National Retail Federation’s Big Show (NRF17) held January 15-17 in ... market’s need for more compact and rugged devices for collecting barcode data paired with ...
Breaking Medicine News(10 mins):
(Date:1/13/2017)... Jan. 13, 2017  Alfalfa, cattle, leafy greens and rosy ... sampling film , which emphasizes the food industry,s shift from ... how COPAN,s Swab Rinse Kit ... surface sampling process in the wake of the new ... COPAN is expanding the U.S. production of ...
(Date:1/13/2017)... Pa. , Jan. 13, 2017  Secretary of ... of students, professors, and community members at Misericordia University ... opioid epidemic in Pennsylvania . ... crisis I,ve seen so far in my professional career," ... has been hit hard by heroin and ...
(Date:1/13/2017)... BOISE, Idaho , Jan. 12, 2017 /PRNewswire/ ... status by Accreditation Commission for Health Care (ACHC) ... the largest national food and drug chain with ... service for pharmacy patients. Accreditation by ... meeting national standards to facilitate a higher level ...
Breaking Medicine Technology: