Navigation Links
Bacteria Fighter Goes Where Antibiotics Can't

Researchers at the Technion-Israel Institute of Technology have figured out a way to turn one of nature’s most powerful microbe //fighters into a guided missile that strikes specifically at a common bacteria responsible for serious infections throughout the body.

Professor Amram Mor of the Biotechnology and Food Engineering Faculty and his colleagues revamped an antimicrobial peptide, a small molecule made of short chains of amino acids that attacks Pseudomonas aeruginosa.

P aeruginosa is the bacterium behind serious lung infections in people with cystic fibrosis and some types of pneumonia and meningitis, as well as less serious but widespread infections such as “swimmer’s ear” and urinary tract infections.

The research was reported in the January 26 issue of the journal Chemistry and Biology. Common antibiotic medicines used to treat infections are increasingly thwarted by new strains of drug-resistant bacteria. Unlike most antibiotics, antimicrobial peptides can sidestep such resistance mechanisms and destroy by brute force, often simply ripping a hole in a targeted cell. For this reason, “antimicrobial peptides present an obvious advantage over conventional antibiotics,” said Mor.

Yet one of the features that makes the peptides so useful—their ability to kill a variety of invaders from bacteria to cancer cells—makes them hard to deploy as a treatment against specific infections. Their “non-specific” action can also destroy normal red blood cells.

The number and order of amino acids in an antimicrobial peptide determines how it recognizes and attacks an invading microbe. Some previous studies have shown that removing amino acids from one end of a peptide can boost its antibacterial properties. However, these shortened peptides are also more deadly to red blood cells.

To build a more useful and less toxic antimicrobial peptide, Mor and colleagues removed a few amino acids from one end of a dermaseptin peptide and replaced it with a fatty acid molecule. (Dermaseptins are a well-known family of peptides that destroy a wide range of microbes). The study shows for the first time that a fatty acid can replace part of a shortened peptide, which may lower the costs of manufacturing such peptides, according to the researchers.

The change made this particular peptide deadly accurate against P. aeruginosa while leaving other bacteria alone. The new peptide was also 60 times less likely to adhere to red blood cells.

“Many experts believe that one of the factors that might hamper the commercial use of antimicrobial peptides is their prohibitive cost. Therefore, smaller means cheaper and in this case, more potent,” Mor said.

Mor said the procedure might be used to create a variety of designer peptides that latch on different microbes, and that his lab will work on repeating the strategy with other peptide chains. The researchers also hope to test these new peptides against infections in animals.

Source-Newsise
SRI
'"/>




Related medicine news :

1. Bacterial discovery may help CF patients
2. Cure for Bacterial Meningitis
3. Before Weight Loss Surgery One Should Get Tested for Bacteria
4. Molecule That Aids Bacterial Infections Identified
5. Moms Stomach Bacteria Can Cause Leukaemia In Children
6. Bacteria Evolve Armamentarium Against Antibiotics By ‘Stealing’ Gens
7. Bacterial Photographs Created By Student Scientists!
8. Bacterial infestation in food very critical!
9. Tooth Decay Bacteria Unaffected By Altered Biochemical Pathway
10. Beneficial Symbiotic Relationship Between Ants And Bacteria.
11. Tamiflu substrate produced from Bioengineered Bacteria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated ... in breathing. Oral appliances can offer significant relief to about 75 percent of ...
(Date:10/12/2017)... ... 2017 , ... The company has developed a suite of ... authorities worldwide. From Children’s to Adults 50+, every formula has been developed by ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, Preservative ...
(Date:10/12/2017)... ... 2017 , ... The American College of Medical Informatics (ACMI) will present the ... Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium ... a pioneer in the field of medical informatics, this prestigious award is presented to ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the ... to develop to enable prevention of a major side effect of chemotherapy in ... in pediatric patients. For cisplatin, hearing loss is FDA listed on-label as a ...
(Date:10/12/2017)... ... ... HMP , a leader in healthcare events and education, today announced that ... for ‘Best B-to-B Healthcare Website.’ Winners were announced during the Eddie & Ozzie Awards ... recognizes editorial and design excellence across a range of sectors. This year’s program included ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... CHICAGO , Oct. 11, 2017  Hill-Rom Holdings, ... its Aspen Surgical facility in Las Piedras, ... surgical scalpels and blades. ... confirmed that the facility sustained minor structural damage, temporary ... Hurricane Maria. Repairs have been completed, manufacturing operations have ...
(Date:10/7/2017)... , Oct. 6, 2017   Provista, a ... than $100 billion in purchasing power, today announced a ... information. The Newsroom is the online home ... trends, infographics, expert bios, news releases, slideshows and events. ... to a wealth of resources at their fingertips, viewers ...
(Date:10/4/2017)... 2017  According to the Centers for Disease Control and Prevention (CDC), ... PhysicianOne Urgent Care is helping communities across Massachusetts , ... by offering no-cost* flu shots through the end of the month. ... insurance regulations. ... get a flu shot is by the end of October, according to ...
Breaking Medicine Technology: