Navigation Links
Bacteria Evolve Armamentarium Against Antibiotics By ‘Stealing’ Gens

Bacteria, like other living organisms, are exposed to ever-changing environments, oxidative stress, and worst of all, antibiotics.// Bacteria are able to defend themselves against all these insults, gain resistance to new antibiotics and attain new abilities simply by ‘stealing’ genetic information from other better-adapted types of bacteria through the bacterial equivalent of sex, known as horizontal gene transfer.

According to the new research, published in the current issue of Nature Genetics, this allows them to evolve the networks of chemical reactions that enable them to do new things, such as defend against antibiotics or antibacterial sprays.

The study, which pieces together the history of new metabolic genes acquired by E. coli over several hundred million years, is the outcome of the first systematic study of how bacteria change their metabolic networks over time. Researchers from the University of Bath, England, University of Manchester, the European Molecular Biology Laboratory and E?tv?s Lorànd University in Hungary studied a benign strain of Escherichia coli to see how the common intestine dweller picked up new parts for its metabolic network--the internal system of chemical reactions that produce the necessities of life, such as amino acids or cellular structures.

The researchers estimate that approximately 25 of E. coli's roughly 900 metabolic genes have been added into its network through horizontal gene transfer in the last 100 million years, as compared to just one addition by gene duplication, where copies of genes are made by accident and then altered over time. The bacterium had genes in its metabolic network that it had pirated from near relatives, including those that enable it to defend itself against antibiotics.

The researchers found that the bacteria do this by way of a process known as horizontal gene transfer, in which a cell passes genetic information to another cell that is not its offspring. It is the bacterial equivalent of sex, with two cells sidling up to each other and engaging in conjugation, or the swapping of genes.

To test why E. coli needed these genes, the researchers cross-examined dozens of E. coli's closest bacterial relatives to see which genes were most commonly exchanged between them. This would highlight the genes that have contributed the most to the evolution of metabolic networks across bacteria.

The researchers found that most of these genes helped bacteria cope with specific environments. Thus, new genes were needed for new functions, rather than affecting the core processes of E. coli, such as how it grows.
'"/>




Related medicine news :

1. Bacterial discovery may help CF patients
2. Cure for Bacterial Meningitis
3. Before Weight Loss Surgery One Should Get Tested for Bacteria
4. Molecule That Aids Bacterial Infections Identified
5. Moms Stomach Bacteria Can Cause Leukaemia In Children
6. Bacterial Photographs Created By Student Scientists!
7. Bacterial infestation in food very critical!
8. Tooth Decay Bacteria Unaffected By Altered Biochemical Pathway
9. Beneficial Symbiotic Relationship Between Ants And Bacteria.
10. Tamiflu substrate produced from Bioengineered Bacteria
11. Bacteria Commonly Seen In Radioactive Waste, Hot Springs Found Inside Humans
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... As health professionals work ... as “patient engagement.” The patient is doing more than filling out a survey; in ... “There is an increasing emphasis in health care and research on the importance of ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... established the certification process to promote standards of excellence for the field of ... scheduled for March 22 – 25, 2018 in Orlando, Florida at the Omni ...
(Date:10/13/2017)... ... ... Lori R. Somekh, founder of the Law Office of Somekh & Associates ... special needs planning attorneys. “Membership in ElderCounsel helps our office remain up to date ... elder law attorneys nationwide,” said Somekh. , ElderCounsel was founded by ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) ... a collection of specialty vendors and unique items from across the nation, this holiday-themed ... and wellness services offered by the VNA. The boutique will be open Saturday, ...
(Date:10/13/2017)... ... 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... popular and least understood books in the Holy Scriptures, Revelation. The Book of Revelation ... scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... Sept. 22, 2017 AVACEN Medical (AVACEN) announced ... now successfully helping those with the widespread pain associated ... diagnosed Amanda in Essex, England ... my hair, experiencing no sleep at all, tremendous pain, ... I cannot recommend [the AVACEN 100] enough, how this ...
(Date:9/19/2017)... , Sept. 19, 2017   ZirMed Inc ., ... analytics, today announced that it has been ranked #1 by ... Black Book™ Rankings 2017 User Survey. ZirMed was recognized ... for large hospitals and medical centers over 200 beds and ... Book,s healthcare technology user survey history. ...
(Date:9/18/2017)... PROVIDENCE, R.I. , Sept. 18, 2017 ... in the fields of bioinformatics and immune ... to develop a protective avian influenza A (H7N9) vaccine. ... is distantly related to seasonal influenza and ... approaches, which rely on prior exposure to be ...
Breaking Medicine Technology: