Navigation Links
Autophagy may Lead to Heart Disease

Autophagy, a normal process by which cells eat their own proteins to provide needed resources to the body in times of stress , may paradoxically cause harm to hearts already weakened by disease, researchers from UT Southwestern Medical Center have found.

In certain forms of heart disease, autophagy is taking place, but how much of it is occurring and whether it participates in disease pathogenesis is unknown, said the studys senior author, Dr. Joseph Hill, chief of cardiology, reporting in the July issue of the Journal of Clinical Investigation.

In our study, we found that autophagy can become harmful and lead to cellular damage.

Autophagy is a highly regulated process that plays a normal role in cell function. It appears to be an adaptive response that protects the body in times of stress or starvation.

But in response to other forms of stress such as hypertension, which can lead to cardiovascular disease, autophagy might also lead to harmful changes in the heart muscle, particularly in decompensated heart failure an inability of the muscle to function and maintain adequate blood flow, the UT Southwestern researchers reported.

In the study, Dr. Hill and his colleagues genetically engineered mice in which the autophagic response was either muted or amplified. Researchers then tested the role of autophagy by inducing heart failure in mice with the varying autophagic responses.

Mice with amplification of autophagy fared worse in terms of cardiac stress than the mice with a muted response, Dr. Hill said. Severe stress leads to increased autophagic activity in heart muscle, and our findings are consistent with the notion that this response actually harms the heart.

Researchers reported that pressure overload, which occurs in chronic hypertension and is a major risk factor for cardiac hypertrophy, or heart enlargement, and heart failure, triggers autophagy in cardiac cells.

We also found that a specific autophagic gene, beclin 1, is a critical factor required for cardiac autophagy, said Dr. Hill, who holds the James T. Willerson, M.D., Distinguished Chair in Cardiovascular Diseases and the Frank M. Ryburn Jr. Chair in Heart Research.

The machinery of autophagy in mammalian cells is not completely understood and even less is known about its function in disease, he said. The autophagic response may also differ in distinct kinds of heart failure, highlighting the need for further study of autophagy in other forms of heart disease.


'"/>




Related medicine news :

1. One in Three Heart Attack Patients Have No Chest Pains
2. Epileptic Seizures Can Be Duec to Heart Problem
3. Bypass Heart Surgery Performed Without General Anesthesia
4. New CPR Guidelines issued by Heart Association
5. White Cells Count Can Predict Heart Attack Death Risk
6. Vitamins-The answer to Heart Disease?
7. Fight Heart disease and Pain with Meditation
8. Heart disease in the newborn is related to maternal malnutrition
9. New drug to treat Heart Attack and damaged tissue
10. Heart disease threat starts early in life for Diabetics
11. Mechanical Heart
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2017)... ... 26, 2017 , ... KICKICO , a protocol built on Ethereum for ... many catastrophic issues within funding campaigns. KICKICO developers are testing the platform, which will ... the raising of funds through the power of many - has been around for ...
(Date:6/25/2017)... ... June 25, 2017 , ... An increase in wetter weather in ... plants, and along with that; a humdinger of an allergy season. A relief from ... an increase in misery-causing grass and weed pollen. , “Our patients have been ...
(Date:6/24/2017)... ... June 24, 2017 , ... The Pennsylvania Athletic Trainers’ Society’s ... and Erie Convention Center on June 8-10. The weekend consisted of many ... award and scholarship presentations, and professional networking. , On Friday June 9th, ...
(Date:6/23/2017)... VA (PRWEB) , ... June 23, 2017 , ... ... of what is needed and will ultimately do significant harm to people with ... to everyone. , "While it leaves in place the Affordable Care Act ...
(Date:6/23/2017)... ... 2017 , ... Dr. Ran Y. Rubinstein , a ... offering three new minimally invasive procedures to patients who want a younger and ... Rubinstein is excited to bring microneedling, microneedling facials, and platelet rich plasma (PRP) ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)... June 14, 2017 The Bio Supply Management ... City of Fremont and the Biomedical Manufacturing ... industry in California by providing ... networking, and fostering workforce development. The primary focus of ... of start-ups, as well as small and mid-sized biomedical ...
(Date:6/10/2017)... June 9, 2017  Shane K. Burchfield, DPM, is recognized by ... as a Podiatrist in Alabama . ... First Foot Care. He brings over 20 years of experience, as ... and healthcare, to his role. ... PC is pleased to welcome you to his practice," ...
(Date:6/8/2017)... 8, 2017  StatLab Medical Products ("StatLab" ... manufacturer of diagnostic supplies for the anatomic ... & Company LP ("Cressey & Company"), a ... growth-focused investment in the Company. Cressey & ... from selling shareholder, Prairie Capital, L.P., with ...
Breaking Medicine Technology: