Navigation Links
Autoimmune disorders studied in detail by U-M researchers.

University of Michigan researchers have been able to zero in (on) the modalities of a drug, capable of rectifying autoimmune disorders and other types of diseases. // Clinical trials on animal models have revealed the capacity of the drug to reduce the potency of a key enzyme, in charge of energy production.

'Many drugs block the function of enzymes, essentially turning them off,' said Gary Glick, who is the Werner E. Bachmann Collegiate Professor of Chemistry at U-M. 'Our compound works more like a volume control, so we’re able to dial enzyme activity down to a level that maintains normal function while simultaneously allowing for initiation of a process that selectively kills or disables disease-causing cells.'

Glick and collaborators published their findings in the June 16 issue of ACS Chemical Biology.

The drug, discovered by Glick and coworkers and called benzodiazepine-423 (Bz-423), is a chemical cousin of anti-anxiety medications such as Valium and Xanax. In previous work, Glick’s group showed that Bz-423 reduces effects of arthritis and the autoimmune disease lupus in mice and may be useful in treating psoriasis. Unlike conventional drugs for these conditions, which can’t discriminate between healthy and disease-causing cells, Bz-423 is highly selective, homing in on disease-causing cells.

In an attempt to better exploit its therapeutic properties, the researchers have been studying the details of Bz-423’s activity. They learned that the compound targets an enzyme inside mitochondria, the energy factories of cells. The specific enzyme, F1F0-ATPase, is responsible for producing most of the cell’s ATP. That’s a critical role because ATP, often referred to as the cell’s energy currency, is the molecule that captures chemical energy from food and transfers it to energy-demanding processes, such as muscle contraction and the transmission of nerve signals.

'People had proposed in the past that if you coul d inhibit this enzyme, there might be therapeutic potential. But the problem is, if you inhibit the enzyme in the way most powerful drugs do, turning it off, you deplete the cell of ATP, and that’s fatal,' Glick said. 'Our new work reveals the mechanism by which Bz-423 inhibits the enzyme while still allowing it to function. This is important because it suggests principles that may be useful for targeting other bioenergetic pathways. Now we have some rules that we can apply to be able to modulate the mitochondria in new ways that could be therapeutic.'

Ultimately, the findings may have applications not only for lupus, arthritis and psoriasis, but also for other conditions, Glick believes. 'There are other diseases – certain cancers and a number of other immune diseases – where we think the way the cells make and utilize energy is fundamental to the disease process. Combining that knowledge with our new knowledge of how to regulate the energy of the cell could open up new avenues for treating disease and monitoring the effectiveness of treatment.'

Glick collaborated on the research with Carol Fierke, who is the Jerome and Isabella Karle Collegiate Professor of Chemistry; Anthony Opipari, Jr., associate professor of obstetrics and gynecology; graduate student Kathryn Johnson and postdoctoral fellow Joanne Cleary. The researchers received funding from the National Institutes of Health.

Source: Eureka Alertbr>

'"/>




Related medicine news :

1. Asbestos Exposure Associated With An Increased Risk For Autoimmune Disease
2. New Oral Medication That Could Arrest Autoimmune Diseases In its early Stages
3. Autoimmune disorder caused due to mutation in cryopyrin protein
4. Gold Therapy- A Potential Treatment For Autoimmune Diseases
5. Autoimmune Diseases – Newer Preventive Measure
6. Understanding Autoimmune Disease
7. A Single Biological Mechanism Behind Several Autoimmune Disorders
8. Researchers Discover New Molecular Path to Fight Autoimmune Diseases
9. Autoimmune Diseases can Be Prevented by Green Tea
10. Individuals with sleep related breathing disorders more prone to heart disease
11. Eating disorders are hereditary
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/27/2016)... ... May 27, 2016 , ... Aimed at nurses and employees in the ... courtesy of leaders in the nursing and health care industry. It also provides insight ... Abilene Christian University. , As the nursing industry is coming out of one ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... W.S. ... products, has been honored with a 2016 When Work Works Award for its use ... part of the national When Work Works project administered by the Families and Work ...
(Date:5/26/2016)... ... May 26, 2016 , ... On Memorial Day, Hope ... lost their lives in military battle for the country. The nonprofit Hope For ... provide more programs that empower independence for disabled military veterans, as well as police, ...
(Date:5/26/2016)... ... May 26, 2016 , ... Catalent Pharma Solutions, the ... consumer health and global clinical supply services, today announced two key appointments and ... continued investment and strategic growth plans in the Asia Pacific region. , Howard ...
(Date:5/26/2016)... ... May 26, 2016 , ... Leadership ... solutions, today announced the organization has earned its ISO 13485 certification, indicating the ... compliant with all rules and policies associated with ISO quality standard 13485. ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... Marziani has joined VMS BioMarketing as senior vice president of sales, announced Andrea ... Marziani will lead the company,s business development and sales team, exploring new opportunities for ... - http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
(Date:5/24/2016)... , May 24, 2016 ... doble terapia del mundo, introduce catéteres para la ... OrbusNeich, una compañía global especializada en el ... ha expandido su cartera incluyendo productos para tratar ... y Scoreflex™ PTA son los dispositivos de primera ...
(Date:5/24/2016)... England , May 24, 2016 ... and Education in Clinical Neurophysiology  Elsevier ... information products and services, today announced the launch of ... an open access journal that focuses on clinical practice ... research, case reports, clinical series, normal values and didactic ...
Breaking Medicine Technology: