Navigation Links
Autoimmune Response in Multiple Sclerosis

In multiple sclerosis (MS), the myelin that surrounds the axons of nerve cells is attacked by the bodys own T cells, resulting in slowed and disrupted nerve impulses and, ultimately, axon loss .

Myelin basic protein (MBP) is a major component of the myelin sheath and when used as an antigen will induce experimental autoimmune encephalitis (EAE) in mice, which is used as an animal model of human MS.

Interestingly, myelin-specific T cells are found in both healthy individuals as well as patients with MS, thus researchers have been working to determine what specific characteristic of these destructive T cells is dominant in driving the development of EAE/MS.

In a study appearing online on July 12 in advance of publication in the August print issue of the Journal of Clinical Investigation, Eli Sercarz and colleagues from the Torrey Pines Institute for Molecular Studies immunized mice with an epitope of MBP known as Ac19, which resulted in a single episode of EAE in these animals, followed by recovery and resistance to any reinduction of disease.

The authors then went on to characterize the Ac19specific T cells present during the induction, onset, and recovery from disease. They identified two distinct subsets of T cells, or clonotypes, soon after immunization and prior to disease onset: BV8S2/BJ2S7 and BV16/BJ2S5.

The BV8S2/BJ2S7 clonotype was found in far greater excess, disappeared with disease recovery, and was found to transfer disease to other healthy mice.

The second clonotype, BV16/BJ2S5, persisted following recovery, consistent with the hypothesis that the other, BV8S2/BJ2S7 T cell clonotype, is the driver of disease and necessary for EAE/MS persistence. The identification of this T cell subset suggests that these cells may be critical targets valuable to the design of therapies for autoimmune diseases such as MS.

AUTHOR CONTACT: Eli E. Sercarz Torrey Pines Institute for Molecular Studies, San Diego, California, USA. Phone: (858) 455-3824; Fax: (858) 455-3715; E-mail:


Related medicine news :

1. Asbestos Exposure Associated With An Increased Risk For Autoimmune Disease
2. New Oral Medication That Could Arrest Autoimmune Diseases In its early Stages
3. Autoimmune disorder caused due to mutation in cryopyrin protein
4. Gold Therapy- A Potential Treatment For Autoimmune Diseases
5. Autoimmune Diseases – Newer Preventive Measure
6. Autoimmune disorders studied in detail by U-M researchers.
7. Understanding Autoimmune Disease
8. A Single Biological Mechanism Behind Several Autoimmune Disorders
9. Researchers Discover New Molecular Path to Fight Autoimmune Diseases
10. Autoimmune Diseases can Be Prevented by Green Tea
11. New Therapeutic Approach for Autoimmune and Inflammatory Diseases
Post Your Comments:

(Date:11/28/2015)... ... 2015 , ... Trying to relax on a couch can actually be uncomfortable, ... this design due to personal experience with a bad back," he said. , This ... as well as increases support. It also makes it easier to eat, do other ...
(Date:11/28/2015)... ... November 28, 2015 , ... Pixel Film Studios is ... panels to choose from, the possibilities are endless. Users have full control over angle ... ProPanel: Pulse masking effects, users are sure to get heads to turn. , ProPanel: ...
(Date:11/27/2015)... ... , ... According to an article published November 13th on, ... D.C. revolved around the fact that proper dental care, both at-home and in the ... between periodontal disease (more commonly referred to as gum disease) and diabetes. According to ...
(Date:11/27/2015)... CO (PRWEB) , ... November 27, 2015 , ... According ... cities are not changing the way that they are handling security in light of ... police and security presence in an attempt to stop an attack from reaching U.S. ...
(Date:11/27/2015)... ... 27, 2015 , ... A team of Swiss doctors has released a report ... has just posted the findings on the website. Click here to read the ... 136 mesothelioma patients who were treated with chemotherapy followed by EPP surgery. Among the ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 ... "Self Administration of High Viscosity Drugs" ... ) has announced the addition of the ... to their offering. --> Research and ... of the "Self Administration of High Viscosity ...
(Date:11/26/2015)... , November 26, 2015 ... of the "Radioimmunoassay Market by Type ... Pharmaceutical Industry, Academics, Clinical Diagnostic Labs), Application ... Forecast to 2020" report to their ... announced the addition of the "Radioimmunoassay ...
(Date:11/25/2015)... ) ... "Global Brain Monitoring Devices Market 2015-2019" ... ) has announced the addition of ... 2015-2019" report to their offering. ... ) has announced the addition of the ...
Breaking Medicine Technology: