Navigation Links
Autism Gene Identified by Yale and Global Consortium

Yale School of Medicine autism experts Fred R. Volkmar, M.D., and Ami Klin are part of a global research consortium from 19 countries that identified an individual gene and a// region of a chromosome that may lead to autism in children.

The findings are published online in Nature Genetics and also will be published in the journal’s March print edition. They are based on the largest autism genome scan done to date. The Autism Genome Project (AGP), including over 120 scientists from over 50 institutions who formed performed the research. The AGP began in 2002 when researchers from around the world decided to collaborate and share their samples, data and expertise to aid in identifying autism susceptibility genes.

Funded by Autism Speaks, a national non-profit organization dedicated to increasing awareness of autism and raising money to research the disorder, and the National Institutes of Health, these are the preliminary findings from the AGP’s first phase.

The consortium used “gene chip” technology to look for genetic similarities in autistic individuals identified within almost 1,200 families. They also scanned the DNA to search for copy number variations, which are submicroscopic insertions and deletions of genetic material that scientists believe may be linked to autism and other disorders.

The researchers found a specific gene called neurexin 1. It is one of a family of genes that plays a role with the neurotransmitter glutamate, which has been previously linked to autism. They also identified a section of chromosome 11 that may contain a gene involved in autism susceptibility. That specific gene has not yet been pinpointed.

“We have known for years that autism is a strongly genetic disorder—this study helps us to significantly advance research on genetic mechanisms,” said Volkmar, study co-author, Yale Child Study Center Director and the Irving B. Harris Professor of Child Psychiatry, Pediatrics and Psycholo gy.

“The concerted effort of multiple agencies bringing together numerous research institutions has led to a new wave of genetic discoveries in autism that markedly change the landscape of knowledge about this highly prevalent disorder,” said Klin, who together with Volkmar, coordinates the Autism Program at Yale.

“The discovery of genes associated with autism and their interactions needs now to set in motion an even stronger effort to develop new pharmacological treatments to change the natural course of this highly heterogeneous family of disorders of socialization,” he said. “These are exciting times in this field.”

Researchers speculate that there may be five or six primary genes and as many as 30 other genes involved in autism, although they recognize that this number could be higher still. They concede that it is still very early to model the ways in which these genes might bring about autism, but the rate of new discoveries is extremely promising.

Autism is a complex brain disorder that inhibits a person’s ability to communicate and develop social relationships, and is often accompanied by extreme behavioral challenges. Autism Spectrum Disorders are diagnosed in one in 150 children in the United States, affecting four times as many boys as girls. The rates of identification of individuals with autism have increased tenfold in the last decade, reflecting a number of factors that include increased awareness of the condition, broadening of its definition, and better educational services.

Source-YALE Univrsity
SRM
'"/>




Related medicine news :

1. Antibiotics Helps Autism
2. Latest discovery on Autism
3. Resolving Autism
4. Studying The Causes Of Autism
5. Mercury Pollution Linked To Rise In Autism
6. Autism risks linked to birth factors
7. Autism epidemic is a myth- says a new study
8. Treating Autism More Effectively
9. MMR Vaccination not linked to Autism
10. Autism nothing more than an extreme form of male brain development
11. Brain Enlargement May Be Characteristic of Autism
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 26, 2016 , ... Many women ... diagnosed with endometriosis. These women need a treatment plan to not only alleviate ... that can help for preservation of fertility and ultimately achieving a pregnancy. The ...
(Date:6/25/2016)... , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on ... Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ability ... fumigation is not a common occurrence, but a necessary one in the event that lice ...
(Date:6/25/2016)... ... 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his ... David Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps ... in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to ...
(Date:6/25/2016)... , ... June 25, 2016 , ... Conventional wisdom preaches ... success. In terms of the latter, setting the bar too high can result in ... than just slow progress toward their goal. , Research from PsychTests.com ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell ... pain and the benefits of holistic treatments, Serenity Recovery Center of Marne, ... Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016  Consumers have taken a more active ... more emphasis on patient outcomes. ... the pharmaceutical industry have evolved beyond just providing ... are focusing on becoming more patient-oriented across their ... services that improve health. ...
(Date:6/24/2016)... 2016   Bay Area Lyme Foundation , ... Center for Tick Borne Illness , Harvard Medical ... Hacking Medicine, University of California, Berkeley, and the ... five finalists of Lyme Innovation , the ... 100 scientists, clinicians, researchers, entrepreneurs, and investors from ...
(Date:6/24/2016)... 2016 The Academy of Managed Care Pharmacy ... that would allow biopharmaceutical companies to more easily share ... formulary and coverage decisions, a move that addresses the ... The recommendations address restrictions in the sharing ... drug label, a prohibition that hinders decision makers from ...
Breaking Medicine Technology: