Navigation Links
Aspirin may Help to Prevent Colon Cancer in High-risk Individuals

A new study has found how medical science could employ aspirin and new aspirin-like drugs for use in preventing colon cancer in certain high-risk individuals.

The study was conducted by a team of researchers led by Sanford Markowitz at the Ireland Cancer Center.

As part of the study, researchers demonstrated the hypothesized mechanism by which the use of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), also called COX-2 inhibitors, act to decrease the risk of developing colon cancer.

Researchers found that two-thirds of colon cancers have high levels of expression of the COX-2 enzyme, which is blocked by aspirin. Individuals who regularly used aspirin over a course of several years demonstrated a 36 percent decrease in the risk of developing one of these high COX-2 expressing colon cancers. These results again demonstrated that drugs that block COX-2 can decrease the risk of colon cancer, and demonstrated that such drugs specifically target those individuals whose tumor development is encouraged by the action of the COX-2 enzyme.

"The compelling evidence that chronic use of aspirin or certain NSAIDS can substantially lower the risk of colon cancer has important implications, especially because colon cancer is the second leading cause of cancer death, Markowitz wrote.

"Interventional trials have shown a decreased risk of the development of colon cancer in high-risk subjects who were given aspirin or COX-2 selective NSAID inhibitors and observational trials have associated a decreased risk of colon cancer with aspirin use," Markowitz added. br>
"The researchers' findings provide powerful support for the role of COX-2 as a key mediator in the development of colon cancer and now pose questions about the biologic basis and clinical applications of discovering differences that express high or low levels of COX-2, he added.

Earlier research by Markowitz in the field of co lon cancer genetics and prevention found that a new Celebrex-like gene called 15-PGDH suppresses the grown of colon cancer, which may lead to the development of a new drug for colon cancer prevention.

Celebrex is a naturally occurring Cox-2 inhibitor.

The findings of the study were published in May issue of New England Journal of Medicine.


'"/>




Related medicine news :

1. What happens when Asthmatics consume Aspirin?
2. Aspirin reduces deaths
3. Aspirin and Warfarin Are Equally Effective for Stroke Prevention
4. Aspirin - a drug after one’s own hear
5. Aspirin deflated
6. Aspirin surpasses Modern Anti-clotting Drugs
7. Night Time Aspirin Regimen Found to Reduce Blood Pressure
8. Aspirin Lowers Leukemia Risk
9. Aspirin usage linked with pancreatic cancer
10. Aspirin Found To Reduce The Risk Of Colon Cancer
11. Aspirin Induced Asthma , A Little-Known Inducer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... June 24, 2016 , ... Advanced ... 2016 Miss Arizona pageant as its official Medspa Sponsor. Dr. Josh Olson, a ... Chandler, Arizona. , Dr. Olson says the decision to support the pageant ...
(Date:6/24/2016)... ... June 24, 2016 , ... Southern Illinois ... are co-chairs for the Illinois State Dental Society (ISDS) Foundation’s Mission of Mercy ... Gateway Convention Center in Collinsville. , They expect to treat approximately ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Seema Daulat, a native Texan and ... South Lamar location as of July 13, 2016. , Dr. Daulat earned her Doctorate ... student, she regularly volunteered at the Agape Clinic serving Dallas’ underprivileged community. , Following ...
(Date:6/23/2016)... ... June 23, 2016 , ... vcfo, a ... support, is pleased to announce the promotion of Mike Mackey to Regional Vice ... Manager where he was responsible for managing client projects and overseeing vcfo financial ...
(Date:6/23/2016)... ... 23, 2016 , ... Virginia Beach resident Sean Kelly suffered from depression after ... to find peace and set out to accomplish a personal mission: a solo 50-mile ... internet. He came across the story of another special operations veteran, Josh Collins, whom ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- Dehaier Medical Systems Ltd. (NASDAQ: DHRM ... sells medical devices and wearable sleep respiratory products in ... agreement with Hongyuan Supply Chain Management Co., Ltd. (hereinafter ... 2016, to develop Dehaier,s new Internet medical technology business. ... leverage Hongyuan Supply Chain,s sales platform to reach Dehaier,s ...
(Date:6/24/2016)... According to a new market ... Needles, Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, ... of Purchase (Retail, Non-Retail) - Trends & Global Forecasts ... market for the forecast period of 2016 to 2021. ... by 2021 from USD 1.65 Billion in 2016, growing ...
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
Breaking Medicine Technology: