Navigation Links
Aspirin may Help to Prevent Colon Cancer in High-risk Individuals

A new study has found how medical science could employ aspirin and new aspirin-like drugs for use in preventing colon cancer in certain high-risk individuals.

The study was conducted by a team of researchers led by Sanford Markowitz at the Ireland Cancer Center.

As part of the study, researchers demonstrated the hypothesized mechanism by which the use of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), also called COX-2 inhibitors, act to decrease the risk of developing colon cancer.

Researchers found that two-thirds of colon cancers have high levels of expression of the COX-2 enzyme, which is blocked by aspirin. Individuals who regularly used aspirin over a course of several years demonstrated a 36 percent decrease in the risk of developing one of these high COX-2 expressing colon cancers. These results again demonstrated that drugs that block COX-2 can decrease the risk of colon cancer, and demonstrated that such drugs specifically target those individuals whose tumor development is encouraged by the action of the COX-2 enzyme.

"The compelling evidence that chronic use of aspirin or certain NSAIDS can substantially lower the risk of colon cancer has important implications, especially because colon cancer is the second leading cause of cancer death, Markowitz wrote.

"Interventional trials have shown a decreased risk of the development of colon cancer in high-risk subjects who were given aspirin or COX-2 selective NSAID inhibitors and observational trials have associated a decreased risk of colon cancer with aspirin use," Markowitz added. br>
"The researchers' findings provide powerful support for the role of COX-2 as a key mediator in the development of colon cancer and now pose questions about the biologic basis and clinical applications of discovering differences that express high or low levels of COX-2, he added.

Earlier research by Markowitz in the field of co lon cancer genetics and prevention found that a new Celebrex-like gene called 15-PGDH suppresses the grown of colon cancer, which may lead to the development of a new drug for colon cancer prevention.

Celebrex is a naturally occurring Cox-2 inhibitor.

The findings of the study were published in May issue of New England Journal of Medicine.


'"/>




Related medicine news :

1. What happens when Asthmatics consume Aspirin?
2. Aspirin reduces deaths
3. Aspirin and Warfarin Are Equally Effective for Stroke Prevention
4. Aspirin - a drug after one’s own hear
5. Aspirin deflated
6. Aspirin surpasses Modern Anti-clotting Drugs
7. Night Time Aspirin Regimen Found to Reduce Blood Pressure
8. Aspirin Lowers Leukemia Risk
9. Aspirin usage linked with pancreatic cancer
10. Aspirin Found To Reduce The Risk Of Colon Cancer
11. Aspirin Induced Asthma , A Little-Known Inducer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/24/2017)... ... 2017 , ... Altec Products, Inc., a leader in enterprise document ... technology conference in San Diego, CA. , At nVerge 2017, Altec will be ... and enhance their Sage ERP solutions by providing improved visibility and control to the ...
(Date:5/24/2017)... ... , ... Patients who want to receive cosmetic dentistry procedures such as Invisalign® ... for a consultation, with or without a referral. Dr. Bedich enjoys improving the appearance ... , Dr. Bedich offers a variety of cosmetic dentistry services at his practice that ...
(Date:5/24/2017)... Lake Orion, Michigan (PRWEB) , ... ... ... is a disease affecting the female reproductive tract in which the endometrial ... the pelvic structures causing inflammation and pain. Patients experiencing painful intercourse, painful ...
(Date:5/24/2017)... ... May 24, 2017 , ... Adelberg-Montalvan Pediatric ... options for its patients on Long Island, New York. , Holistic dentistry ... and is one of the biggest trends in dentistry today. , Dentist ...
(Date:5/24/2017)... (PRWEB) , ... May 24, 2017 , ... Technique, technique, ... back injury when either lifting weights for strength training and exercise or simply lifting ... Center . , “Body position is everything,” Dr. Chang says. “Improper technique in lifting ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... 2017 Zimmer Biomet Holdings, Inc. (NYSE and ... announced it has earned a spot on Forbes, ... Company was ranked among 500 U.S. employers as well ... Equipment and Services. The annual Forbes ... independent survey of over 30,000 employees across 25 industries. ...
(Date:5/9/2017)... May 9, 2017  Oramed Pharmaceuticals Inc. (NASDAQ: ... clinical-stage pharmaceutical company focused on the development of ... Canadian Intellectual Property Office has granted Oramed a ... of Exenatide". The patent covers Oramed,s invention of ... GLP-1 is an incretin hormone that stimulates the ...
(Date:5/8/2017)... NEW YORK , May 8, 2017 ... in the transition from fee for service reimbursement. Black ... April 2017. 1.       The Market for ... 77% of physician practices with 3 or ... Compliance Technology Solutions by Q4. "Given the magnitude of ...
Breaking Medicine Technology: