Navigation Links
Aspirin induces Cancer Cells To Commit Suicide

Aspirin has already been hailed as a wonder drug that can take care of everything from Alzheimer's disease to heart attacks. It has now emerged that it can also induce cancer cells to commit suicide.//

Researchers from the University of Pittsburgh report in the December 9 issue of the Journal of Biological Chemistry that aspiration can prove to be deadly for cancer cells in combination with a new therapy called as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). They add that if these findings are corroborated in larger clinical studies then aspirin could prove to be a blessing for the treatment of recurring colon and prostate cancers. "When cancers recur after initial therapy, they tend to be extremely aggressive and patient prognosis is poor. If we could find ways to prevent these secondary cancers from occurring, we could save many lives. Aspirin is a low-cost medicine that, in our studies, appears to have great potential for helping to prevent such cancer recurrences,' commented Yong J. Lee, Ph.D., professor in the departments of surgery and pharmacology, University of Pittsburgh School of Medicine, and lead author of the study.

TRAIL is basically a protein that has been found to trigger apoptosis or programmed death of cancer cells with little or no effect on the normal ones. However, many studies have highlighted the fact that some cancers are resistant to TRAIL. It is in this scenario that aspirin proves to be useful. It was found that when cancer cells were pre-treated with aspirin they lost a key protein called Bcl-2, which protects healthy cells from premature death.'In this study we demonstrated that aspirin can down-regulate Bcl-2 gene expression and consequently change the electrical potential of the mitochondrial membrane in cancer cells, thereby releasing cytochrome c and other apoptotic proteins,' said Dr Lee. This study could indeed hold a key as far as preventing of aggressive recurrence of cancers is concerned.< br>
Other authors of the study include Kim M. Kim, Ph.D., and Jae J. Song, Ph.D., department of surgery, University of Pittsburgh School of Medicine, and Jee Young An, Ph.D., and Yong Tae Kwon, Ph.D., Center for Pharmacogenetics, department of pharmaceutical sciences, University of Pittsburgh School of Pharmacy.

Contact: Jim Swyers / Clare Collins SwyersJP@upmc.edu / CollCX@upmc.edu 412-647-3555 / 412-647-3555 University of Pittsburgh Medical Center
'"/>




Related medicine news :

1. What happens when Asthmatics consume Aspirin?
2. Aspirin reduces deaths
3. Aspirin and Warfarin Are Equally Effective for Stroke Prevention
4. Aspirin - a drug after one’s own hear
5. Aspirin deflated
6. Aspirin surpasses Modern Anti-clotting Drugs
7. Night Time Aspirin Regimen Found to Reduce Blood Pressure
8. Aspirin Lowers Leukemia Risk
9. Aspirin usage linked with pancreatic cancer
10. Aspirin Found To Reduce The Risk Of Colon Cancer
11. Aspirin Induced Asthma , A Little-Known Inducer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... Austin, TX (PRWEB) , ... June 25, 2016 , ... ... Fellow of the American College of Mohs Surgery and to Dr. Russell Peckham for ... popular and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic ...
(Date:6/25/2016)... City, Oklahoma (PRWEB) , ... June 25, 2016 ... ... helping both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic ... the Oklahoma City area —Johnson is one of the first doctors to perform ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle ... chronic pain and the benefits of holistic treatments, Serenity Recovery Center of ... Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is ... Road To Recovery® program to drive cancer patients to and from their cancer treatments. ... the highest quality of life and ongoing independence. Getting to and from medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Grove Investment Group (TGIG), has initiated cultivation and processing operations at its production ... and Pahrump, Nevada. , Puradigm is the manufacturer of a complete system of ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Bracket , a leading clinical trial technology ... outcomes platform, Bracket eCOA (SM) 6.0, at the 52 ... 30, 2016 in Philadelphia , Pennsylvania.  A ... product of its kind to fully integrate with RTSM, will ... 6.0 is a flexible platform for electronic clinical outcomes assessments ...
(Date:6/23/2016)... , June 23, 2016 Revolutionary ... Oticon , industry leaders in advanced audiology ... of Oticon Opn ™, the world,s first internet ... possibilities for IoT devices.      (Photo: ... introduces a number of ,world firsts,: , ...
(Date:6/23/2016)... , June 23, 2016  Experian ... integrating and transforming the patient payment and ... several innovative new products and services that ... its revenue cycle offerings. These award-winning solutions ... efficient workflows, remain compliant in an ever-changing ...
Breaking Medicine Technology: