Navigation Links
Aspirin induces Cancer Cells To Commit Suicide

Aspirin has already been hailed as a wonder drug that can take care of everything from Alzheimer's disease to heart attacks. It has now emerged that it can also induce cancer cells to commit suicide.//

Researchers from the University of Pittsburgh report in the December 9 issue of the Journal of Biological Chemistry that aspiration can prove to be deadly for cancer cells in combination with a new therapy called as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). They add that if these findings are corroborated in larger clinical studies then aspirin could prove to be a blessing for the treatment of recurring colon and prostate cancers. "When cancers recur after initial therapy, they tend to be extremely aggressive and patient prognosis is poor. If we could find ways to prevent these secondary cancers from occurring, we could save many lives. Aspirin is a low-cost medicine that, in our studies, appears to have great potential for helping to prevent such cancer recurrences,' commented Yong J. Lee, Ph.D., professor in the departments of surgery and pharmacology, University of Pittsburgh School of Medicine, and lead author of the study.

TRAIL is basically a protein that has been found to trigger apoptosis or programmed death of cancer cells with little or no effect on the normal ones. However, many studies have highlighted the fact that some cancers are resistant to TRAIL. It is in this scenario that aspirin proves to be useful. It was found that when cancer cells were pre-treated with aspirin they lost a key protein called Bcl-2, which protects healthy cells from premature death.'In this study we demonstrated that aspirin can down-regulate Bcl-2 gene expression and consequently change the electrical potential of the mitochondrial membrane in cancer cells, thereby releasing cytochrome c and other apoptotic proteins,' said Dr Lee. This study could indeed hold a key as far as preventing of aggressive recurrence of cancers is concerned.< br>
Other authors of the study include Kim M. Kim, Ph.D., and Jae J. Song, Ph.D., department of surgery, University of Pittsburgh School of Medicine, and Jee Young An, Ph.D., and Yong Tae Kwon, Ph.D., Center for Pharmacogenetics, department of pharmaceutical sciences, University of Pittsburgh School of Pharmacy.

Contact: Jim Swyers / Clare Collins SwyersJP@upmc.edu / CollCX@upmc.edu 412-647-3555 / 412-647-3555 University of Pittsburgh Medical Center
'"/>




Related medicine news :

1. What happens when Asthmatics consume Aspirin?
2. Aspirin reduces deaths
3. Aspirin and Warfarin Are Equally Effective for Stroke Prevention
4. Aspirin - a drug after one’s own hear
5. Aspirin deflated
6. Aspirin surpasses Modern Anti-clotting Drugs
7. Night Time Aspirin Regimen Found to Reduce Blood Pressure
8. Aspirin Lowers Leukemia Risk
9. Aspirin usage linked with pancreatic cancer
10. Aspirin Found To Reduce The Risk Of Colon Cancer
11. Aspirin Induced Asthma , A Little-Known Inducer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/18/2019)... ... July 18, 2019 , ... The Radiology ... Congress about new bills to protect patients from unexpected out-of-network medical bills incurred ... Surprise Medical Bills Act ( H.R. 3502 ), introduced in the U.S. House ...
(Date:7/18/2019)... ... ... Dr. Todd Britten says he and his staff try to keep up ... him by his patients. A recent news report highlighting a study that showed concerns ... in his Clearwater, Florida practice. Dental floss harmful studies (source: Harvard.edu) The ...
(Date:7/17/2019)... ... July 17, 2019 , ... Guruji Mahendra Trivedi, ... perspectives on today’s issues affecting humanity at practical and spiritual levels. Guruji Mahendra ... Saturday, July 20, 2019. , Guruji Mahendra Trivedi offers these powerful workshops to ...
(Date:7/17/2019)... (PRWEB) , ... July 17, 2019 , ... ... presidents and administrators of critical access hospitals. , The men and women included ... have overseen hospital expansions, mergers and EHR implementations as well as the construction ...
(Date:7/17/2019)... Texas (PRWEB) , ... July 17, 2019 , ... This ... with the Smiles for Everyone Foundation . Over 50 underserved patients were welcomed ... extractions , and more while celebrating the summer season. Individuals were referred to the ...
Breaking Medicine News(10 mins):
(Date:7/17/2019)... ... July 17, 2019 , ... On July 1, 2019, Oklahoma Magazine named Whole Leaf ... For the past 20 years Oklahoma Magazine has released its Best of the Best to ... the Best award recognizes Whole Leaf for having several strains of marijuana with varying levels ...
(Date:7/17/2019)... ... ... Women’s Excellence is pleased to offer Natural Family Planning (NFP) to women as a ... that is consistent with Catholic marriage vows by which a couple recognizes the natural, ... sexual contact during the fertile time. To achieve pregnancy, the couple engages in marital ...
(Date:7/13/2019)... ... July 12, 2019 , ... Southern California healthcare group West Medical ... significantly overweight patients, particularly those who may not meet the standard criteria for bariatric ... to reduce the available area of the stomach – and thereby reduce the appetite ...
Breaking Medicine Technology: