( highest dosages and 150 males and 150 ...)Artificial Sweetners Not Really Safe?,,,Health

highest dosages and 150 males and 150 females at all lower dosages and controls.

The experiment ended after the death of the last animal at 159 weeks. At spontaneous death, each animal underwent examination for microscopic changes in all organs and tissues, a process different from the aspartame studies conducted 30 years ago and one that was designed to allow aspartame to fully express any carcinogenic potential.

The treated animals showed extensive evidence of malignant cancers including lymphomas, leukemias, and tumors at multiple organ sites in both males and females. The authors speculate the increase in lymphomas and leukemias may be related to one of the metabolites in aspartame, namely methanol, which is metabolized in both rats and humans to formaldehyde. Both methanol and formaldehyde have shown links to lymphomas and leukemias in other long-term experiments by the same authors.

The current study included more animals over a longer period than earlier studies. “In our opinion, previous studies did not comply with today’s basic requirements for testing the carcinogenic potential of a physical or chemical agent, in particular concerning the number of rodents for each experimental group (40–86, compared to 100–150 in the current study) and the termination of previous studies at only 110 weeks of age of the animals,” the study authors wrote.

Source: journal Environmental Health Perspectives (EHP)

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