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Arthritis and the Wnt Factor

ation mainly in synovium of RA but in synovium, cartilage, osteophyte, and bone of OA. Also findings show that Wnt-7b was recurrently found at sites of inflammation and elicited an inflammatory response, which are consistent with inflammation as a hallmark of RA disease.

This identifies Wnt-7b processing a role in arthritic processes. Arthritic diseases are known to manifest differently depending on the type, with RA displaying inflammation to the synovium and loss of cartilage and bone, and OA exhibiting a narrowing of joint space, loss of protective cartilage, and growth of bone cysts.
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