Navigation Links
Arthritis and the Wnt Factor

An article by Nakamura et al., "Expression profiles and functional analyses of Wnt-related genes// in human joint disorders," will appear in the July issue of The American Journal of Pathology. The article revolves around the protein, Wnt. Wnt is a proto-oncogene since its disruption can lead to cancer in various organs. But current evidence might show that it is also involved in arthritic joint disease.

At present a through analysis of the Wnt gene family has been pending towards the progression of arthritis. A group of researchers at Shinshu University in Nagano, Japan have examined 19 members of the Wnt gene family. There study is to find out which gene is involved in arthritic joint disease. The study is being performed under the supervision of the assistant professor at the Department of Orthopedic Surgery, Dr, Shingeyuki Wakitani. The study also includes examination of joint tissues from patients who have undergone total knee replacements for rheumatoid arthritis (RA), osteoarthritis (OA), or non-arthritic injury.

The group had identified certain genes, which were upregulated in the arthritic knee tissues. These were Wnt-7b and Wnt –10a. The above was found with molecular methods, while protein expression studies reveal that only Wnt-7b was produced in arthritic joints, with strong protein localization to the synovium (or joint lining) and weak localization to cartilage and bone.

The author also examines whether inflammatory cytokines were produced in primary cartilage and synovial cells from arthritic versus normal joints. While OA cells did not differ from controls, primary RA cells produced TNF-a, IL-1? and IL-6 at levels 2- to 4-fold above controls. Importantly, this effect could be replicated in normal cells when they were engineered to express Wnt-7b, demonstrating the importance of Wnt-7b in the inflammatory response of RA.

Wnt-7b was noticed to be strongly upregulated within joints at sites of disease manifest
'"/>




Page: 1 2

Related medicine news :

1. Another ray of hope for Arthritis Sufferers
2. Naked DNA Vaccination May Conquer Arthritis and Multiple Sclerosis
3. B Vitamin protects and lowers toxicity of Arthritis Drug
4. FDA Approves New Arthritis Drug, Bextra
5. Risk Of Developing Arthritis
6. Arthritis Drug May Cause Liver Damage
7. Arthritis drug can prolong life
8. New treatment for Rheumatoid Arthritis
9. Important cause of Arthritis
10. Personality Impacts Arthritis
11. New Rheumatoid Arthritis Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Arthritis and the Wnt Factor

(Date:8/1/2015)... ... 01, 2015 , ... Western University of Health Sciences’ newest ... a growing percentage of U.S. physicians, and reflects the diversity of the communities ... the message delivered by John W. Becher, DO, president of the American Osteopathic ...
(Date:8/1/2015)... ... ... Brig and Lita Hart, icons of the network marketing industry and founders of the ... HOPE Movement of EvolvHealth. In what has been a long-term relationship between the companies ... missions of purpose together to change the course of the network marketing industry. , ...
(Date:8/1/2015)... (PRWEB) , ... August 01, 2015 , ... “ reTXT ... look at the latest and coolest applications on the market for iOS, Android, and ... and shared with viewers allows users to clarify, edit and delete any message including ...
(Date:7/31/2015)... ... , ... The Honor Society of Nursing, Sigma Theta Tau International (STTI) convened ... 20-21 July 2015 in San Juan, Puerto Rico. Key nurse leaders from Central and ... Advisor, Nursing and Allied Health Personnel Development, Unit of Human Resources for Health, Department ...
(Date:7/31/2015)... Alexandria, VA (PRWEB) , ... July 31, 2015 ... ... Foundation) introduced its new store run by GoodThreads. The store can be accessed ... products and designs, many of which are customizable. The best part: whenever a ...
Breaking Medicine News(10 mins):Health News:COMP-Northwest Welcomes Class of 2019 2Health News:COMP-Northwest Welcomes Class of 2019 3Health News:COMP-Northwest Welcomes Class of 2019 4Health News:COMP-Northwest Welcomes Class of 2019 5Health News:Looking for HOPE? Healthy Home Has Evolv’d 2Health News:Looking for HOPE? Healthy Home Has Evolv’d 3Health News:Correct Auto-Correct and Clarify the Unclear with reTXT Messaging App 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 3Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 4Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3
... Do not assume that standing under a tree affords complete ... the sun comes out, it's pleasant to sit under a ... from the sun. But don't take the shade for granted, ... ,They've built a mathematical model which reveals just how much ...
... According to an anti-ageing research, the liver is a ... the Concord Hospital, felt that there are many wonderful ... pharmacology and toxicology.//Your mortgage is paid off, your children ... are, and you have the benefit of wisdom and ...
... a new research, a computer screening program can accurately diagnose ... program is missing. In a study of more than 1,000 ... the diagnostic tool identified more than 80% of people who ... emergency department physicians may be able to rely on the ...
... likely to die or suffer heart problems after major surgery ... in which a person either loses the ability to respond ... at all, is a major risk factor for heart disease, ... D. Hamdan and colleagues found that, though diabetes has been ...
... University, Dallas, new ways should be adopted for patients' safety ... you can on the road and it may be that ... help people in hospital too.// Doctors at the Hopkins University ... the context of injury and improving technology, rather than assigning ...
... Dallas, using disinfectant gels, rather than hand rubs, for hospital ... doctors and nurses to wash their hands between each patient ... infections.// Soap and water is used in US, while in ... soap and water is time consuming, the rubs are drying ...
Cached Medicine News:Health News:Liver key to extending life 2Health News:Computer Program can assist to detect Heart Attack 2
(Date:7/31/2015)... CHICAGO , July 31, 2015 ... Composition Analyzers Market by Product (Bioimpedance Analyzers (BIA), Dual-Energy ... and Hydrostatic Weighing) - Global Analysis & Forecast to ... Market was pegged at $911.1 Million 2014 and is ... at a CAGR of 9.4% from 2014 to 2019. ...
(Date:7/30/2015)... July 30, 2015  ResMed (NYSE: ... a definitive agreement to acquire Curative Medical, ... and sleep-disordered breathing medical devices and accessories. ... in China, combined with ResMed,s global leadership in sleep and respiratory ... China suffering from sleep-disordered ...
(Date:7/30/2015)... IRVINE, Calif. , July 30, 2015 /PRNewswire/ ... Novartis /Alcon executives have recently contacted the Company ... will begin as early as Monday, August 3, ... been quoted as saying that the coming electronic ... billions of dollars over the next several years.  ...
Breaking Medicine Technology:Body Composition Analyzers Market Worth $1,425.7 Million by 2019 2Body Composition Analyzers Market Worth $1,425.7 Million by 2019 3Body Composition Analyzers Market Worth $1,425.7 Million by 2019 4ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 2ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 3
... Maine, July 14, 2011 IDEXX Laboratories, Inc. (Nasdaq: ... its 2011 second quarter financial results for Friday, July ... conduct an analyst conference call beginning at 9:00 a.m. ... Individuals can access a live Webcast of the ...
... Biomedical Corporation (OTCBB:QTXB), an emerging leader in the ... on its patented technology platforms for the worldwide ... the lawsuit with NURX, its prior Joint Venture ... operations to expand its over-the-counter products and laboratory ...
Cached Medicine Technology:QuantRx Biomedical Settles Suit: Launches New PAD-Based Genomic Diagnostic Products 2QuantRx Biomedical Settles Suit: Launches New PAD-Based Genomic Diagnostic Products 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: