Researchers at The University of Manchester have discovered that arthritis pain, unlike that induced as part of an experiment, is processed in the //parts of the brain concerned with emotions and fear.

A team led by Dr Bhavna Kulkarni has captured the first images of how the brain processes arthritis pain, using positron emission tomography (PET) scanners based at the Christie Hospital.

In a study funded by the Arthritis Research Campaign and published in 'Arthritis and Rheumatism' this week, they compare the brain areas involved in processing arthritic and experimental pain in a group of patients with osteoarthritis.

Dr Kulkarni said: "We knew from our previous neuro-imaging studies that experimentally-induced pain is processed in at least two brain networks, collectively known as the ‘pain matrix.’ The ‘medial pain system’ processes the emotional aspects such as pain’s unpleasantness, while the ‘lateral pain system’ processes the pain’s intensity, location and duration.

"We wanted to see whether the same applied to the clinical pain suffered by people with conditions like arthritis, as no direct comparisons of experimental and clinical pain had been undertaken in the same group of patients."

Six female and six male patients with osteoarthritis of the knee underwent PET brain-scanning during three different pain states: arthritic knee pain, experimental knee pain (when no arthritic pain was present) and a pain-free state. Each patient also rated their perceived pain intensity and unpleasantness on 0 – 100 rating scales at 10 minute intervals.

"We thought that arthritic and acute experimental pain would be processed within the same areas of the pain matrix," Dr Kulkarni continued. "But, although both activated both the medial and lateral pain systems, arthritic pain prompted increased activity in the cingulate cortex, thalamus and amygdale within the medial system - the areas concerned with processin
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