Navigation Links
Are mature cells better than stem cells for cloning?

According to scientists in the U.S. cloning can be performed without the stem cells and other mature cells seem to perform better//.

Two baby mice were created from fully matured blood cell that cannot produce more of its kind, by a team at the Pittsburgh University. This is contrary to the general notion that only immature stem cells that can differentiate in to several different types of cells are capable of doing it.

Somatic cell nuclear transfer (SCNT) is a method of cloning in which, an embryo is generated by transferring the nucleus or the genetic material of the cell to an unfertilized egg whose own genetic material has been removed. The embryo generated is an exact replica of the donor of the genetic material.

Scientists had pinned their hopes on stem cells as they are still at an early stage of development and have the capacity to differentiate into different types of cells forming tissues and organs. Hence, they were hopeful of treating several genetic disorders. However, the rate of success was only 1-5% in studies using adult stem cells from mature tissue to generate early stage embryo.

Dr Tao Cheng and colleagues conducted studies to detect if granulocytes, fully matured white blood cells, could be used to generate early embryos. The success rate was high and in fact, it performed better than stem cells destined to become granulocytes.

Early stage embryos called blastocysts were generated from 35-39% of the mature granulocytes. However, only 4% of the immature stem cells could generate blastocysts. Two live cloned mice pups could be generated only by the differentiated granulocytes, though they died a couple of hours after birth.

To confirm their findings, the scientists performed cloning using embryonic stem cells, cells derived from blastocysts. Almost 50% yielded blastocysts and 18 cloned pups were born. However, the use of embryonic stem cells is controversial. Thus, sci entists are looking for successful substitutes for embryonic stem cells.

Dr Cheng said, "The results clearly show there is no advantage in using adult stem cells over mature fully differentiated cells. We can say with near certainty that a fully differentiated cell such as a granulocyte retains the genetic capacity for becoming like a seed that can give rise to all cell types necessary for the development of an entire organism."

Stem cell expert Dr Stephen Minger, from King's College London, said: "The findings are quite surprising. "Up until this [point], the conventional wisdom was that the less mature a cell, the more likely it is to be reprogrammed. This work suggests the contrary. "Certain types of mature cells could be much easier to reprogramme than expected.

"But of course this has only been done in mice and there could be a big difference when it comes to humans. It would be interesting to see whether the same is found with human cells."
GYT
'"/>




Related medicine news :

1. Unpredictable Premature Birth
2. Mothers with periodontitis may deliver premature babies
3. Death due to premature heartbeat after exercise
4. Women who conceive after a year have a higher chance of giving birth prematurely
5. Women who conceive after a year have a higher chance of giving birth prematurely
6. Benefits of Nitric Oxide in the Treatment of Premature Infants
7. Gene is related to premature ageing disease
8. Drug for cancer may help restrict premature labor
9. Premature Babies More Likely If Women Have Higher Protein Albumin In Urine
10. Hyaluronic Acid – A Boon To The Problem Of Premature Infant
11. Premature Aging Can Be Managed With Anti-Cancer Drugs In Future
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2017)... ... March 27, 2017 , ... Mt. ... launch of a months-long rebranding effort. This includes the introduction of new packaging ... discussions and market research, we learned that a simple, proactive approach to wellness ...
(Date:3/27/2017)... ... March 27, 2017 , ... The homeowner improvement and repair market is ... DIY and unlicensed contractors for renovations is also on the rise. Per a 2017 ... and of those, 42% failed to use a licensed contractor.(2) The risks associated with ...
(Date:3/25/2017)... Fort Atkinson, Wisconsin (PRWEB) , ... March 25, 2017 , ... Norland at Swissray ... and body composition analyzers for large subjects. The ELITE DXA has an active scan ... are too wide or long to fit in the scan area could not undergo an ...
(Date:3/24/2017)... York, NY (PRWEB) , ... March 24, 2017 ... ... global scale; from third world countries to hospitals in the United States, it’s ... a conversation on the current obstacles facing infection prevention and offers strategies for ...
(Date:3/24/2017)... San Antonio, TX (PRWEB) , ... March 24, 2017 , ... ... a new clinic which can be found at 9618 Huebner Road. The clinic is ... Thobaben, PT, OCS, Clinic Director, and Dr. Ali Higgins, PT, will provide care from ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... -- FinancialBuzz.com News Commentary   ... Medical cannabis products around the world are projected to gain ... medical cannabis market will reach a value of USD 55.8 billion by ... the new growing industry. By the end of 2016, 28 states have ... cannabis. More conservative states like Arkansas and ...
(Date:3/24/2017)... Today Stock-Callers.com have issued research reports on four ... NVCN), Hologic Inc. (NASDAQ: HOLX), Edwards Lifesciences Corp. (NYSE: EW), ... companies are part of the Healthcare sector, which gave back ... , 2017, with the NYSE Health Care Index declining 0.2% ... the S&P 500 were down about 0.4% as a group. ...
(Date:3/24/2017)... , March 23, 2017  Mirabilis Medical, ... advanced medical technology for non-invasive surgery, announced today ... System for treatment of uterine fibroids throughout the ... had received approval from the US Food and ... the Mirabilis System in the United States.  The ...
Breaking Medicine Technology: