Navigation Links
Are mature cells better than stem cells for cloning?

According to scientists in the U.S. cloning can be performed without the stem cells and other mature cells seem to perform better//.

Two baby mice were created from fully matured blood cell that cannot produce more of its kind, by a team at the Pittsburgh University. This is contrary to the general notion that only immature stem cells that can differentiate in to several different types of cells are capable of doing it.

Somatic cell nuclear transfer (SCNT) is a method of cloning in which, an embryo is generated by transferring the nucleus or the genetic material of the cell to an unfertilized egg whose own genetic material has been removed. The embryo generated is an exact replica of the donor of the genetic material.

Scientists had pinned their hopes on stem cells as they are still at an early stage of development and have the capacity to differentiate into different types of cells forming tissues and organs. Hence, they were hopeful of treating several genetic disorders. However, the rate of success was only 1-5% in studies using adult stem cells from mature tissue to generate early stage embryo.

Dr Tao Cheng and colleagues conducted studies to detect if granulocytes, fully matured white blood cells, could be used to generate early embryos. The success rate was high and in fact, it performed better than stem cells destined to become granulocytes.

Early stage embryos called blastocysts were generated from 35-39% of the mature granulocytes. However, only 4% of the immature stem cells could generate blastocysts. Two live cloned mice pups could be generated only by the differentiated granulocytes, though they died a couple of hours after birth.

To confirm their findings, the scientists performed cloning using embryonic stem cells, cells derived from blastocysts. Almost 50% yielded blastocysts and 18 cloned pups were born. However, the use of embryonic stem cells is controversial. Thus, sci entists are looking for successful substitutes for embryonic stem cells.

Dr Cheng said, "The results clearly show there is no advantage in using adult stem cells over mature fully differentiated cells. We can say with near certainty that a fully differentiated cell such as a granulocyte retains the genetic capacity for becoming like a seed that can give rise to all cell types necessary for the development of an entire organism."

Stem cell expert Dr Stephen Minger, from King's College London, said: "The findings are quite surprising. "Up until this [point], the conventional wisdom was that the less mature a cell, the more likely it is to be reprogrammed. This work suggests the contrary. "Certain types of mature cells could be much easier to reprogramme than expected.

"But of course this has only been done in mice and there could be a big difference when it comes to humans. It would be interesting to see whether the same is found with human cells."

Related medicine news :

1. Unpredictable Premature Birth
2. Mothers with periodontitis may deliver premature babies
3. Death due to premature heartbeat after exercise
4. Women who conceive after a year have a higher chance of giving birth prematurely
5. Women who conceive after a year have a higher chance of giving birth prematurely
6. Benefits of Nitric Oxide in the Treatment of Premature Infants
7. Gene is related to premature ageing disease
8. Drug for cancer may help restrict premature labor
9. Premature Babies More Likely If Women Have Higher Protein Albumin In Urine
10. Hyaluronic Acid – A Boon To The Problem Of Premature Infant
11. Premature Aging Can Be Managed With Anti-Cancer Drugs In Future
Post Your Comments:

(Date:11/27/2015)... ... 2015 , ... CBD College is proud to announce that on ... accreditation to its Diagnostic Medical Sonography program. CBD College is honored to join this ... colleges and universities in the state of California make the cut. CBD College is ...
(Date:11/27/2015)... San Francisco, California (PRWEB) , ... November 27, 2015 , ... ... 1969 Janis Joplin Ann Arbor Michigan boxing style concert posters. This is one of ... 1969 at the Canterbury House at the University of Michigan in Ann Arbor. The ...
(Date:11/26/2015)... ... November 26, 2015 , ... Inevitably when people think Thanksgiving, they also think ... during the Black Friday and Cyber Monday massage chair sales to receive ... high and low to find the best massage chair deals, they can see all ...
(Date:11/26/2015)... (PRWEB) , ... November 26, 2015 , ... ... of workshops to discuss bioavailability and the need to integrate dose form selection ... in collaboration with OBN, the membership organization supporting and bringing together the UK’s ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... opinion process, participated in the 61st annual Employee Benefits Conference. The Employee Benefits ... place Sunday, November 8th through Wednesday, November 11th, 2015. The conference was held ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... STOCKHOLM , November 26, 2015 ... the potential to use SyMRI to find optimal contrast weighting ... brain tumor metastases, and has signed a research agreement with ... at the hospital. Using SyMRI, it is possible to generate ... parameter settings after the patient has left, thus making it ...
(Date:11/26/2015)... ) has ... Future Horizons and Growth Strategies in the ... Shares, Country Segment Forecasts, Competitive Intelligence, Emerging ... --> ) has announced the ... and Growth Strategies in the French Drugs ...
(Date:11/26/2015)... Research and Markets ( ) has announced the ... Type (Dressings, Therapy Devices, Active Wound Care), Application (Surgical ... Geography - Global Forecast to 2020" report to ... --> The purpose of this report is to ... advanced wound care market. It involves deep dive analysis ...
Breaking Medicine Technology: