Navigation Links
Aprotinin in the treatment of hemorrhagic shock trauma patients

The conservative treatment of bleeding from solid abdominal organs has been traditionally based on massive fluid resuscitation and correction of coagulopathy, which has latelybeen recognized as detrimental. // Although there are new and sophisticated methods for the control of hemorrhage, bleeding is still the direct cause of death in up to 40% of trauma-related deaths.

There is a continuous search for the "magical drug" that can improve coagulation, reduce bleeding, and increase the time span between the injury and the occurrence of irreversible shock. Early administration of such drug in the field would allow more injured patients to reach the surgical facility, where the means for bleeding control is available.

Aprotinin is known to promote clot formation through its antifibrinolytic activity, by inhibiting the plasmin-induced complement activation and by protecting the platelets adhesive surface receptors. It has been successfully used in cardiac and liver transplantation surgery.

In view of its properties in clot formation, improved coagulation, and its antifibrinolytic activity, a recent study was designed to evaluate the effect of aprotinin in a model of uncontrolled intra-abdominal bleeding as the basis for potential use in trauma patients.

For the study, published in the September issue of The American Journal of Surgery, 20 rats were randomly divided into 2 groups. All animals were operated on and bleeding was induced by transecting 1 lobe of the liver. In the treatment group a single dose of 30,000 U/kg of aprotinin was administered 5 minutes after the injury. The animals were monitored for hemodynamic parameters, blood loss volume, and mortality rates.

Early administration of aprotinin resulted in temporary hemodynamic stabilization and prolonged survival in a model of uncontrolled bleeding. Further studies are needed to establish the possible use of aprotinin in the treatment of trauma patients .

The authors stress that in view of the results of this present study and the data already published on the uses of aprotinin in situations where bleeding is of major concern, further studies are warranted to establish the possible use of aprotinin in the treatment of trauma patients.

Related medicine news :

1. Thyroid hormone treatment hastens recovery after cardiac surgery
2. Feeding channel created by malaria parasite - a new target for malaria treatments
3. Now umbilical cord helps in stroke treatment.
4. Now AIDS treatment comes dirt-cheap
5. Breast cancer treatment to be determined by gene test
6. Hemopurifier may revolutionise AIDS treatment
7. New drug helps boost cancer treatment
8. Antidepressants come in handy for patients on treatment for hepatitis, cancers and multiple sclerosis
9. Experimental treatment for Ebola Virus Shows promising results in mice
10. Radioactive Seeds used in Prostate Cancer treatment can migrate with the body
11. New dimension in the treatment of female sexual dysfunction
Post Your Comments:

(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... ... hold the festivities in the friendly confines of their home. Whether it's making ... neighbors, try these Halloween recipes from Florida Dairy Farmers. , Recipe 1: ...
(Date:10/13/2015)... ... 2015 , ... Boulder native and lifelong athlete, Mark Gonglach, ... Tested by Olympic and professional athletes, he developed the combined massage and vibration ... sporting equipment and high-tech sales led him to transition from Rally Software to ...
(Date:10/13/2015)... ... October 13, 2015 , ... CURE Media ... today announced a new partnership with the International Waldenstrom’s Macroglobulinemia Foundation (IWMF) ... non-Hodgkin’s lymphoma, their families and physicians. , “Waldenstrom’s Macroglobulinemia is a so-called ...
(Date:10/13/2015)... ... 13, 2015 , ... According to an article published October 5th ... who successfully lose weight with a bariatric procedure are much less likely to develop ... notes that anywhere from 40 to 50 percent of all endometrial cancer cases are ...
(Date:10/13/2015)... ... October 13, 2015 , ... In an age where the ... 36 percent lower per square foot than in 2009. The Williamsport Regional Medical Center ... and cooling has decreased by eight percent. , According to Facilities Management Administrative ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... ) has ... European markets for Meniscal Repair - 16 Countries ... ) has announced the addition of ... Repair - 16 Countries (2010-2021)" report to ... ( ) has announced the addition of ...
(Date:10/13/2015)... , Oct. 13, 2015   Vigilant Biosciences, Inc. ... that aid in the early detection and intervention of ... Vigilant,s founder and CEO, Matthew H.J. Kim , ... which recognizes an entrepreneur who has made extraordinary contributions ... life sciences industry in the leadership of a company ...
(Date:10/13/2015)... , Oct. 13, 2015  EndoChoice Holdings, Inc. ... third quarter 2015 financial results on Thursday, November 5, ... . --> . ... Thursday, November 5, 2015 at 9:00 a.m. ET to ... for domestic callers and (412) 317-5469 for international callers. ...
Breaking Medicine Technology: