Navigation Links
Aprotinin in the treatment of hemorrhagic shock trauma patients

The conservative treatment of bleeding from solid abdominal organs has been traditionally based on massive fluid resuscitation and correction of coagulopathy, which has latelybeen recognized as detrimental. // Although there are new and sophisticated methods for the control of hemorrhage, bleeding is still the direct cause of death in up to 40% of trauma-related deaths.

There is a continuous search for the "magical drug" that can improve coagulation, reduce bleeding, and increase the time span between the injury and the occurrence of irreversible shock. Early administration of such drug in the field would allow more injured patients to reach the surgical facility, where the means for bleeding control is available.

Aprotinin is known to promote clot formation through its antifibrinolytic activity, by inhibiting the plasmin-induced complement activation and by protecting the platelets adhesive surface receptors. It has been successfully used in cardiac and liver transplantation surgery.

In view of its properties in clot formation, improved coagulation, and its antifibrinolytic activity, a recent study was designed to evaluate the effect of aprotinin in a model of uncontrolled intra-abdominal bleeding as the basis for potential use in trauma patients.

For the study, published in the September issue of The American Journal of Surgery, 20 rats were randomly divided into 2 groups. All animals were operated on and bleeding was induced by transecting 1 lobe of the liver. In the treatment group a single dose of 30,000 U/kg of aprotinin was administered 5 minutes after the injury. The animals were monitored for hemodynamic parameters, blood loss volume, and mortality rates.

Early administration of aprotinin resulted in temporary hemodynamic stabilization and prolonged survival in a model of uncontrolled bleeding. Further studies are needed to establish the possible use of aprotinin in the treatment of trauma patients .

The authors stress that in view of the results of this present study and the data already published on the uses of aprotinin in situations where bleeding is of major concern, further studies are warranted to establish the possible use of aprotinin in the treatment of trauma patients.

Related medicine news :

1. Thyroid hormone treatment hastens recovery after cardiac surgery
2. Feeding channel created by malaria parasite - a new target for malaria treatments
3. Now umbilical cord helps in stroke treatment.
4. Now AIDS treatment comes dirt-cheap
5. Breast cancer treatment to be determined by gene test
6. Hemopurifier may revolutionise AIDS treatment
7. New drug helps boost cancer treatment
8. Antidepressants come in handy for patients on treatment for hepatitis, cancers and multiple sclerosis
9. Experimental treatment for Ebola Virus Shows promising results in mice
10. Radioactive Seeds used in Prostate Cancer treatment can migrate with the body
11. New dimension in the treatment of female sexual dysfunction
Post Your Comments:

(Date:11/25/2015)... ... November 25, 2015 , ... ... athletic programs, launches new Wimbledon Athletics Facebook page to educate the ... for unsuspected cardiac abnormalities. About 2,000 people under the age of 25 die ...
(Date:11/25/2015)... IL (PRWEB) , ... November 25, 2015 , ... On ... assets of Tri Lite’s personal heating products business. Cozy Products explains what ... personal heaters that fit in well with the Cozy Products business model: to sell ...
(Date:11/25/2015)... ... 25, 2015 , ... SCOTTSDALE, AZ) - Today, Dr. ... both surgical and non-surgical treatments, announced the expansion of his private practice capabilities ... , Highly trained and nationally recognized for his natural approach, Dr. Todd ...
(Date:11/25/2015)... ... November 25, 2015 , ... Brillianteen, ... friendships, and learning in its 65th Anniversary Brillianteen Revue, scheduled for March 4-6, ... , For 65 years, Brillianteen has been a treasured tradition for numerous families ...
(Date:11/25/2015)... ... November 25, 2015 , ... “While riding the bus, I saw a ... “I thought there had to be a convenient and comfortable way to protect them ... enables disabled individuals to safely travel during cold or inclement weather. In doing so, ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... UTRECHT , Nederland, November 26, 2015 ... --> Een nieuwe aanpak combineert ... van gevorderde kanker. ... -->      (Photo: ... van het Leids Universitair Medisch Centrum (LUMC) ...
(Date:11/26/2015)... , November 26, 2015 3D bioprinting ... 2022, according to a new report by Grand View Research ... Disease (CKD) which demands kidney transplantation is expected to boost ... effective substitute for organ transplantation. --> 3D bioprinting ... 2022, according to a new report by Grand View Research ...
(Date:11/26/2015)... 26, 2015 ... of the  "2016 Future Horizons and ... Surface Testing Market: Supplier Shares, Competitive ... offering.  --> ) ... "2016 Future Horizons and Growth Strategies ...
Breaking Medicine Technology: