Navigation Links
Aprotinin in the treatment of hemorrhagic shock trauma patients

The conservative treatment of bleeding from solid abdominal organs has been traditionally based on massive fluid resuscitation and correction of coagulopathy, which has latelybeen recognized as detrimental. // Although there are new and sophisticated methods for the control of hemorrhage, bleeding is still the direct cause of death in up to 40% of trauma-related deaths.

There is a continuous search for the "magical drug" that can improve coagulation, reduce bleeding, and increase the time span between the injury and the occurrence of irreversible shock. Early administration of such drug in the field would allow more injured patients to reach the surgical facility, where the means for bleeding control is available.

Aprotinin is known to promote clot formation through its antifibrinolytic activity, by inhibiting the plasmin-induced complement activation and by protecting the platelets adhesive surface receptors. It has been successfully used in cardiac and liver transplantation surgery.

In view of its properties in clot formation, improved coagulation, and its antifibrinolytic activity, a recent study was designed to evaluate the effect of aprotinin in a model of uncontrolled intra-abdominal bleeding as the basis for potential use in trauma patients.

For the study, published in the September issue of The American Journal of Surgery, 20 rats were randomly divided into 2 groups. All animals were operated on and bleeding was induced by transecting 1 lobe of the liver. In the treatment group a single dose of 30,000 U/kg of aprotinin was administered 5 minutes after the injury. The animals were monitored for hemodynamic parameters, blood loss volume, and mortality rates.

Early administration of aprotinin resulted in temporary hemodynamic stabilization and prolonged survival in a model of uncontrolled bleeding. Further studies are needed to establish the possible use of aprotinin in the treatment of trauma patients .

The authors stress that in view of the results of this present study and the data already published on the uses of aprotinin in situations where bleeding is of major concern, further studies are warranted to establish the possible use of aprotinin in the treatment of trauma patients.
'"/>




Related medicine news :

1. Thyroid hormone treatment hastens recovery after cardiac surgery
2. Feeding channel created by malaria parasite - a new target for malaria treatments
3. Now umbilical cord helps in stroke treatment.
4. Now AIDS treatment comes dirt-cheap
5. Breast cancer treatment to be determined by gene test
6. Hemopurifier may revolutionise AIDS treatment
7. New drug helps boost cancer treatment
8. Antidepressants come in handy for patients on treatment for hepatitis, cancers and multiple sclerosis
9. Experimental treatment for Ebola Virus Shows promising results in mice
10. Radioactive Seeds used in Prostate Cancer treatment can migrate with the body
11. New dimension in the treatment of female sexual dysfunction
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2017)... ... March 27, 2017 , ... Mt. ... launch of a months-long rebranding effort. This includes the introduction of new packaging ... discussions and market research, we learned that a simple, proactive approach to wellness ...
(Date:3/27/2017)... ... March 27, 2017 , ... The homeowner improvement and repair market is ... DIY and unlicensed contractors for renovations is also on the rise. Per a 2017 ... and of those, 42% failed to use a licensed contractor.(2) The risks associated with ...
(Date:3/25/2017)... Fort Atkinson, Wisconsin (PRWEB) , ... March 25, 2017 , ... Norland at Swissray ... and body composition analyzers for large subjects. The ELITE DXA has an active scan ... are too wide or long to fit in the scan area could not undergo an ...
(Date:3/24/2017)... York, NY (PRWEB) , ... March 24, 2017 ... ... global scale; from third world countries to hospitals in the United States, it’s ... a conversation on the current obstacles facing infection prevention and offers strategies for ...
(Date:3/24/2017)... San Antonio, TX (PRWEB) , ... March 24, 2017 , ... ... a new clinic which can be found at 9618 Huebner Road. The clinic is ... Thobaben, PT, OCS, Clinic Director, and Dr. Ali Higgins, PT, will provide care from ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... -- FinancialBuzz.com News Commentary   ... Medical cannabis products around the world are projected to gain ... medical cannabis market will reach a value of USD 55.8 billion by ... the new growing industry. By the end of 2016, 28 states have ... cannabis. More conservative states like Arkansas and ...
(Date:3/24/2017)... Today Stock-Callers.com have issued research reports on four ... NVCN), Hologic Inc. (NASDAQ: HOLX), Edwards Lifesciences Corp. (NYSE: EW), ... companies are part of the Healthcare sector, which gave back ... , 2017, with the NYSE Health Care Index declining 0.2% ... the S&P 500 were down about 0.4% as a group. ...
(Date:3/24/2017)... , March 23, 2017  Mirabilis Medical, ... advanced medical technology for non-invasive surgery, announced today ... System for treatment of uterine fibroids throughout the ... had received approval from the US Food and ... the Mirabilis System in the United States.  The ...
Breaking Medicine Technology: