Navigation Links
Appetite-regulating Peptides Influence Alcohol Cravings

A new study has confirmed that appetite-regulating peptides leptin and ghrelin influence alcohol cravings for some alcoholics.

Craving, a powerful urge to drink, is an important contributor to the development and maintenance of alcoholism.

Professor Otto Lesch of the University of Vienna has divided patients of alcohol dependence into four groups Type 1 that refers to people with heavy alcohol withdrawals who tend to use alcohol to weaken withdrawal symptoms, Type 2 patients use alcohol as self-medication because of its anxiolytic effects, Type 3 which is an affective disorder as origin for alcohol abuse, and Type 4 patients pre-morbid cerebral defects, behavioral disorders and a high social burden.

The study showed a positive association between leptin and craving among patients of Leschs Type 1 and 2, and between leptin and craving among patients consuming beer or wine.

It also revealed a negative trend between ghrelin and craving among patients of Leschs Type 1.

"We chose to examine leptin and ghrelin because both peptides are of high importance in appetite regulation and both have already been subject to former investigations," said Thomas Hillemacher, Assistant Professor in the Department of Psychiatry and Psychotherapy at the University Hospital of Erlangen, Germany.

"However, these former investigations have shown contradictory results which may have been due to their use of samples of alcoholics without specifying subgroups. This raised the idea of investigating these peptides in specific subtypes of alcohol dependence." he added.

The researchers analysed data gathered as part of a larger examination of different neurobiological aspects of alcohol dependence. Of the original sample of 200 patients, 188 provided leptin serum levels, and 117 provided ghrelin serum levels.

After measuring craving through the Obsessive Compulsive Drinking Scale, the study authors classified patients in accordance with Leschs typology of alcohol dependence, as well as their preferred type of alcoholic beverage.

"The study showed that the involvement of appetite-regulating peptides in the neurobiology of alcohol craving is of different importance in specific subgroups," said Hillemacher.

The researchers also stressed the need for the identification of subgroups of alcoholics for future studies as well as clinical applications.

"Our findings show that there exist important differences between alcohol-dependent patients, not only regarding psychosocial but also regarding neurobiological influences," said Hillemacher.

"To explain addiction, we need mechanisms of different types of craving. Addiction is not caused by the drug, but is caused by biological and psychological vulnerabilities leading to different types of craving," added Lesch.


'"/>




Related medicine news :

1. Specific Imbalance Between Two Peptides may Cause Alzheimers
2. Diet Can Influence Allergic Skin Reactions
3. Influence of diet on allergic Reactions
4. Alcoholism Influenced By Both Genetics & Family Environment
5. Hunger Found To Influence Taste
6. Body Weight Found To Influence PSA Levels
7. Depressed Mothers Found To Influence Their Child’s Behavio
8. Childhood Obesity May Influence The Their Quality Of Life
9. Elevated Insulin Levels To Influence Levels Of Inflammatory Markers
10. Vitamins Found To Influence Birth Weight
11. Influence of Celebrities on Breast Cancer Awareness
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/2/2016)... Fla. (PRWEB) , ... May ... ... medical researchers report that many commonly used prescription medications, including anxiolytics, painkillers, ... To mitigate these risks, Novus Medical Detox Center —a leading Florida-based ...
(Date:5/2/2016)... ... May 02, 2016 , ... Pregnancy Awareness Month offers a great ... , “If you are ready to have a baby, it’s best to ... HealthChequesTM: Journal Babies is your Personal Conception & Pregnancy Organizer, written for women who ...
(Date:5/2/2016)... , ... May 02, 2016 , ... ... and urgent care facilities designed to automate and improve the rapid diagnosis, triage ... it is demonstrating their platform, application, and mobile experience for the first time ...
(Date:5/2/2016)... ... May 02, 2016 , ... Consultative health care market ... Jim Callandrillo and Duane Reed, VP of business development of AJMC Strategic Solutions, ... Research Group (PBIRG) General Meeting from May 15-17 at the Boca Raton ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... Atlantic Information ... CMS’s Medicare Part B Payment Model Could Transform the Pharma Landscape .” CMS recently ... on reducing its spend on provider-administered drugs while preserving care provided to beneficiaries. The ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... NEW YORK , May 2, 2016 /PRNewswire/ ... Series B financing of Graybug Vision, Inc. Graybug ... to developing therapies that may transform care for ... and glaucoma.  Graybug Vision,s technology was first developed ... out into a startup venture. ...
(Date:5/2/2016)...  Celsion Corporation (NASDAQ: CLSN ), an ... the first cohort of patients in its Phase ... combining GEN-1, the Company,s DNA-based immunotherapy, with the ... patients with advanced ovarian cancer who will undergo ... the first three patients dosed, GEN-1 plus standard ...
(Date:4/29/2016)... COUNTY, Calif. , April 29, 2016 /PRNewswire/ ... industry is projected to shift from systems dependent ... replace all types of modality CRT Medical monitors ... Although there are a host of foreseeable benefits ... serious concern; will existing modalities have to be ...
Breaking Medicine Technology: