Navigation Links
Antipsychotic Drug Controls Some Symptoms in Autism Disorder

Risperidone, a drug used to control schizophrenia symptoms, may also help treat behaviors found in autism spectrum disorder, according to a new review of studies.//

The reviewers looked at three randomized, placebo-controlled studies of risperidone (Risperdal) involving 211 participants, including 31 adults.

“[We found] that risperidone may be beneficial for various aspects of autism including irritability, repetition and hyperactivity,” said researchers led by Dr. Ora Jesner of the University of Bristol, in England. But the drug’s benefits may be offset by its side effects, with weight gain the most prominent.

Often diagnosed within the first three years of life, autism spectrum disorder leads to difficulties with social relationships, language and communication skills. Symptoms include withdrawal from social interactions, irritability, problems communicating and repetitive behaviors.

It is known as a “spectrum” disorder because there is a wide variation in how it affects individuals. Figures from the U.S. Centers for Disease Control and Prevention show that as many as 1.5 million Americans may have some form of the disorder.

“Autism spectrum disorder affects many families worldwide,” Jesner said. “At present many of the interventions available are not evidence-based.” He said he and co-author Dr. Mehrnoosh Aref-Adib “wanted to analyze the evidence for one important antipsychotic [drug] used for the condition.”

The review appears in the latest issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates medical research. Systematic reviews draw evidence-based conclusions about medical practice after considering both the content and quality of existing medical trials on a topic.

Because of the small number of studies, wide range of different scales used to assess outcomes and sizes of the trials themselves, the research ers were only able to look at how well the patients responded for the three specific symptoms of irritability, repetitive movement and social withdrawal.

In addition to weight gain, significant side effects included involuntary muscle movements. As the studies were of short duration, long-term side effects and usefulness remain unknown. Since risperidone does not cure the disorder and may have to be continued for a long period of time, this is an important missing piece.

Susan Levy, M.D., director of the Regional Autism Center at The Children’s Hospital of Philadelphia, said that the authors’ weak support for the medication in the conclusion surprised her.

“The researchers seemed to be lukewarm towards their positive findings,” said Levy, who was not involved with the study. “From my personal experience, this medication can be quite helpful for behavioral difficulties.”

The Cochrane reviewers and Levy stress that parents and caregivers should be careful about expecting too much from the medication when talking about this treatment with their doctors. Not all behavioral problems can be helped with risperidone and both side effects and improvements from the drug should be considered.

“As ASD is diagnosed at a young age and these short trials lack long-term data, parents or caregivers need to be aware it is not known how long the medication needs to be continued — potentially for a lifetime,” the researchers said. “This is particularly important given the side effects.”

Levy termed risperidone “a more serious medication” that she would reserve for more serious difficulties.

“It needs to be stressed to the parents and others that this is not a cure for autism or for the core symptoms of ASD,” Levy said. “But it works well for some of the associated problems.” Source-Newswise
SRM
'"/>




Related medicine news :

1. Antipsychotic Drug Linked to Pulmonary Embolism
2. New Antipsychotic Medications have Little Advantage Over Older Drugs
3. Antipsychotics – not effective in treating Alzheimer
4. No Evidence to Support Many Off-label Uses of Atypical Antipsychotics
5. Scientists Uncover Cause of Antipsychotic Drug Weight Gain
6. Study Sheds Light on Value of Newer Antipsychotic Drugs for Schizophrenia
7. Scientists Discover Hormone That Controls Hunger
8. Brain behind the Brawn: Vital Molecule in the Brain Controls Appetite
9. Stronger Quadricep Controls Knee Osteoarthritis
10. Pair of MicroRNA Molecules Controls Major Oncogene in Most Common Leukemia
11. Molecular ‘On/Off Switch’ Controls Immune Defenses Against Viruss
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... ... April 28, 2016 , ... Greener Hydroponics is now offering a ... frequently used by professional organic farmers and nurseries according to Sales Manager Joe Steele ... fabric pots. Our goal is to offer wholesale level pricing and ultra-fast shipping for ...
(Date:4/28/2016)... Illinois (PRWEB) , ... April ... ... the leading provider of enterprise Data Center Infrastructure Management solutions, announces today ... focuses on feature enhancements in the area of capacity management and optimization, ...
(Date:4/28/2016)... ... ... reminds us that May is National Stroke Awareness Month. According to the Centers for ... the United States; someone has one every 40 seconds. Annually, almost 800,000 strokes occur ... A stroke is when blood flow to the brain is blocked or when a ...
(Date:4/28/2016)... ... April 28, 2016 , ... A first-time look at workers’ compensation claims in ... Workers Compensation Research Institute (WCRI) announced, and that costs per claim were ... Kentucky, 16th Edition , found that indemnity costs per claim and benefit delivery expenses ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... it will demonstrate its leading secure mobility workstation suite, SentinelSecure™, at MobileIron’s 6th ... Hilton Union Square, this will be MobileIron’s 6th Mobile First Conference and will ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... , April 28, 2016  The blood testing market ... dollars, according to Kalorama Information and The Freedonia Group ... and nucleic acid testing.  The healthcare research firm said ... in developing blood collection stations and in improving testing ... Kalorama Information,s report, Blood Testing Market in ...
(Date:4/28/2016)... April 28, 2016   Acsis , a leading ... leading IT market research and advisory firm IDC has ... IDC MarketScape: Worldwide Pharmaceutical Track and Trace Software 2016 ... provides an assessment of the capabilities and business strategies ... software market. Logo - http://photos.prnewswire.com/prnh/20160427/360791LOGO ...
(Date:4/27/2016)... , Schweiz, April 27, 2016 ... Sachs CEO Forums in Zürich gab Strekin ... führenden Wirkstoffkandidaten STR001 zur Erhaltung des Resthörvermögens ... wurde, bekannt. Für die umfassende Phase-II-Doppelblindstudie mit ... Frankreich angeworben. STR001 wird während der Operation ...
Breaking Medicine Technology: