Navigation Links
Antioxidant Molecule Could Help Minimize Stroke-Linked Brain Damage

A novel peptide discovered by researchers at Weill Cornell Medical College could prove a potent weapon against stroke, a new study// finds.

The compound, called SS31, is able to cross the blood-brain barrier and inhibit an oxidative stress molecule recently linked to stroke-related tissue damage.

"In our experiments, we found that exposing mice to SS31 after an induced ischemic stroke led to a much smaller area of brain tissue being affected," says the study's lead author Dr. Sunghee Cho, assistant research professor of neuroscience at Weill Cornell Medical College. Dr. Cho is also assistant professor of neurology/neuroscience and director of preclinical stroke modeling at the Burke Medical Research Institute in White Plains, N.Y.

The new study suggests that SS31 works by inhibiting the activity of CD36, a "scavenger" receptor that Dr. Cho and her colleagues in the Department of Neurology/Neurobiology at Weill Cornell Medical College have previously linked to stroke-induced tissue damage.

The findings were recently published in the Journal of Biological Chemistry.

Each year, millions of Americans are affected by strokes or "transient ischemic attacks," otherwise called "mini-strokes." Damage to brain tissue occurs not just during the blockage itself, but after the blockage is cleared, as blood rushes back to the site in a process known as reperfusion.

"Reperfusion creates a lot of oxidative stress and related damage to neural tissues," explains study senior author Dr. John Pinto, a research scientist at Burke. "A lot of that damage seems to be caused by a heightened activity of CD36."

So, the question was: Is there a molecule that can reach the stroke site and keep CD36 from acting as it does

Luckily, another researcher at Weill Cornell, professor of pharmacology Dr. Hazel Szeto, had already developed a candidate antioxidant peptide, SS31. Dr. Szeto is a co-researcher on the current paper.

"Dr. Szeto was, in fact, looking for a model of ischemia to test out SS31," Dr. Cho says. "Since we knew the molecule could pass through the blood-brain barrier -- something most drugs cannot do -- SS31 seemed to be a perfect fit."

In their experiments, the Weill Cornell team induced ischemic stroke in mice, then treated the mice soon after with SS31.

The results were impressive. "The size of infarct -- tissue damage -- in the mouse brain cortex was significantly reduced in the treated vs. untreated animals," Dr. Pinto says.

Another promising sign: high brain levels of an oxidative stress marker called glutathione, which is usually depleted in areas affected by stroke/reperfusion.

"If you have a stroke, you lose glutathione very quickly," Dr. Cho says. "That happened in the untreated mice, but SS31 seemed to keep glutathione levels relatively high in the treated animals."

But how was SS31 working its magic? To help find out, the team tested the drug in mice genetically engineered to lack functioning CD36.

"For these mice, treatment with SS31 after stroke had no effect," Dr. Cho says. "That suggests that this peptide is working via inhibiting CD36 pathways."

The exact mechanism by which SS31 inhibits CD36 remains unclear, she says. "We have theories -- for example, it may block binding of CD36 with LDL cholesterol, reducing LDL oxidation. But there could be multiple pathways. We just don't know."

The researchers stressed that human stroke is much more complex than that seen in mice, so the true value of SS31 as a stroke-limiting drug remains to be seen.

Still, they are optimistic.

"Right now, stroke patients have very limited treatment options, so an effective agent that could reach the site of injury and lessen damage would be a great advance," Dr. Cho says.

Source-Newswise
'"/>




Related medicine news :

1. Antioxidants protect health tissue in people undergoing radiation therapy.
2. Antioxidants found in chocolates
3. Antioxidants used for longevity
4. Antioxidants found in chocolates
5. The Use Of Antioxidants To Diminish Effects of Alcohol During Pregnancy Questioned
6. Mother’s Milk Stored For Long Periods Found To Have Less Antioxidant
7. Antioxidants in the body protects the airways from diesel exhaust effect
8. Fruit And Vegetable Peels Are Rich Source Of Potent Antioxidants
9. Antioxidant Selenium Offers No Major Protection against Heart-Disease
10. Preeclampsia Risk Cant Be Overcome By Taking Antioxidants
11. Mushrooms are Rich Source of Antioxidants
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... , ... June 25, 2016 , ... Austin residents seeking ... American College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical ... effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library ... City Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ... for fumigation is not a common occurrence, but a necessary one in the event that ...
(Date:6/25/2016)... ... ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize each ... Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into hand ... select a ProHand generator and drag it above media or text in the Final ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency ... named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. ... Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe ... from the David Geffen School of Medicine at UCLA. He trained in Internal Medicine ... his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CHAPEL HILL, N.C. , June 24, 2016 ... in healthcare decisions and regulators/payers have placed more ... this new environment, patient support programs in the ... support for patients, medications. Consequently, pharmaceutical companies are ... to ensure they are providing products and services ...
(Date:6/24/2016)... June 24, 2016  Collagen Matrix, Inc., ("Collagen ... and manufacturing of collagen and mineral based medical ... that Bill Messer has joined the ... further leverage the growing portfolio of oral surgery, ... Bill joins the Collagen Matrix executive team ...
(Date:6/24/2016)... 24, 2016  Global Blood Therapeutics, Inc. (GBT) (NASDAQ: ... novel therapeutics for the treatment of grievous blood-based ... closing of its previously announced underwritten public offering ... public offering price of $18.75 per share. All ... by GBT. GBT estimates net proceeds from the ...
Breaking Medicine Technology: