Navigation Links
Antihistamine Proved Ineffective in Making Kids to Sleep

Antihistamines used to put young children sleep was found ineffective – researchers from Georgetown University Medical Center reports//.

Study suggested that children (under age 2) who received diphenhydramine drug showed no benefits from its effectiveness.

In fact, the national study, conducted by researchers from Georgetown University Medical Center and published in the July issue of Archives of Pediatrics & Adolescent Medicine, found that the drug appeared to perform worse than a placebo agent. Only 1 out of 22 children showed improvement in sleeping after using diphenhydramine compared to 3 in 22 children who used a placebo. The drug, an antihistamine, is available over-the-counter in generic forms or as the name-brand drug, Benadryl?.

Because of diphenhydramine's obvious lack of effectiveness, the clinical trial's Data Safety Monitoring Board shut down the study early, says lead author, Dan Merenstein, M.D., an assistant professor in the Department of Family Medicine at Georgetown.

‘This is a small study, but one with big implications, because it is looking at the effectiveness of a widely used drug that has not been examined for infant and toddler use,’ says Merenstein. Half of pediatricians recommend use of diphenhydramine, according to surveys, and many child-rearing books offer the same advice, ‘but because the drug works as a sleep aide for some adults, we pretend it works for everyone,’ he says.

Merenstein cautions that a larger study is needed to definitively prove that diphenhydramine doesn't work as thought in young children, but adds, ‘At this point I would advise parents to think about different methods to help a child sleep,’ Merenstein says.

Researchers at Johns Hopkins University, Virginia Fairfax University, and the University of Hawaii worked with Merenstein on the study, which he conducted at Johns Hopkins before coming to Georgetown.

The clinical trial, known as TIRED (Tri al of Infant Response to Diphenhydramine), enrolled 44 children, age 6-15 months, with the participation of their parents, and followed the families for six weeks. During this time, parents kept diaries to record the sleep habits of their children throughout the night. Treatment with a placebo agent or diphenhydramine occurred during one week, and the days before and after treatment were recorded for comparison purposes. The study was blinded in that neither researchers nor parents knew which children received which treatment.

The investigators had hypothesized that, based on the sedative properties of diphenhydramine in adults, treated children would be more likely to fall asleep without any other help from their parents, and that doing so would lead them to associate the crib with sleep and comfort, helping them to fall back asleep if they woke up.

But Merenstein says the results were surprising. Diphenhydramine use was no more effective than a placebo in reducing nighttime awakening, ‘or improving overall parental happiness with sleep for infants,’ he says.

Merenstein also notes that while it is generally reported about 7 percent of diphenhydramine users become ‘hyperactive,’ and so have increased sleep problems, only one child showed some evidence of hyperactivity. Still, he says, ‘it is possible that diphenhydramine caused low-level hyperactivity in children, negating the sleep benefits seen in some adults, but we really don't know why it didn't work.’

‘The bottom line here is that parents and pediatricians should rely on evidence-based medicine and not on leaps of logic that border on folklore,’ Merenstein says.

Sourc: Eurekalert
'"/>




Related medicine news :

1. Nasal Spray Beats Antihistamine
2. Antihistamine Could also be used as a Potential Antimalarial Drug
3. Travelers’ Hazard- Antihistamines Make Drowsy Driver
4. Plastic Sling Has Proved Successful In Improving Aging Of The Neck
5. Non Hormonal Therapies for Menopause Not Proved to be Effective
6. An After-Dinner Nap Is A Natural Thing, Scientists Proved
7. Womb Transplants are Possible - Research Proved
8. Preventive Measures Proved Ineffective in Allergic Children
9. Anti-Glycolytic Therapy Proved to be Effective Against Tumors
10. Procalcitonin-Guided Antibiotic Therapy Proved Effective in CAP Cure
11. Aspirin and other NSAIDS Proved Less Effective in Long-Term Smokers
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Talented ... the lowdown on sciatica in a new episode of "Success Files," which is ... events and innovation and investigates each subject in-depth with passion and integrity. , ...
(Date:10/12/2017)... ... 12, 2017 , ... First Healthcare Compliance (FHC), an industry ... a range of technology and learning solutions at the 68th Annual American Healthcare ... be held October 14–18, 2017 at the Mandalay Bay Resort in Las Vegas, ...
(Date:10/12/2017)... ... , ... IsoComforter, Inc. ( https://isocomforter.com ), one of the Nation’s ... design of the shoulder pad. The shoulder pad provides optimal support and full ... while using cold therapy. By utilizing ice and water that is circulated from an ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... Hair Restoration, has recently contributed a medical article to the newly revamped ... Dr. Mohebi’s article spotlights the hair transplant procedure known as Follicular Unit ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... of Michigan’s 2017 Best and Brightest in Wellness® by Best and Brightest. OnSite ... program on Friday, Oct. 20 from 7:30 a.m. to 2 p.m. at the ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... , Sept. 27, 2017  Commended for their devotion ... notable awards. Ranked as number one in the South Florida ... time in Inc. 5000 yearly list, the national specialty pharmacy ... Armando Bardisa will soon be honored by SFBJ ... Set to receive his award in ...
(Date:9/23/2017)... -- Janssen Biotech, Inc. (Janssen) announced today that it ... Food and Drug Administration (FDA) for the Biologics License ... of moderately to severely active rheumatoid arthritis (RA). The ... to further evaluate the safety of sirukumab in the ... "We are disappointed by ...
(Date:9/19/2017)... , Sept. 19, 2017   ZirMed Inc ., ... analytics, today announced that it has been ranked #1 by ... Black Book™ Rankings 2017 User Survey. ZirMed was recognized ... for large hospitals and medical centers over 200 beds and ... Book,s healthcare technology user survey history. ...
Breaking Medicine Technology: