Navigation Links
Antihistamine Could also be used as a Potential Antimalarial Drug

Researchers have found that astemizole, which is used for treating allergy can also be used as a potential drug for treating malaria//.

According to a study conducted by researchers from the Johns Hopkins Bloomberg School of Public Health and the Johns Hopkins University School of Medicine. The study, largely funded by the Johns Hopkins Malaria Research Institute (MRI), determined that in a test tube the antihistamine killed the parasite, Plasmodium falciparum, which causes malaria in humans, including parasite strains that were resistant to traditional malaria therapies. The drug was also shown to be effective in mouse models. The findings are published in the July 2, 2006, advanced online edition of Nature Chemical Biology.

“Time and money are major roadblocks when it comes to developing new drugs for the treatment of neglected diseases like malaria,” said senior study author David Sullivan, MD, an associate professor with MRI and the Bloomberg School’s W. Harry Feinstone Department of Molecular Microbiology and Immunology. “Astemizole is promising as an antimalarial, but still needs to be evaluated for effectiveness as an antimalarial in humans.”

For the study, Sullivan and colleagues Curtis Chong and Jun Liu of the Johns Hopkins School of Medicine’s Department of Pharmacology first assembled the Johns Hopkins Clinical Compound Library, which is a collection of 2,687 drugs. Seventy percent of the compounds are approved by the U.S. Food and Drug Administration, while the remaining 30 percent are approved by regulatory agencies in other countries. The researchers screened the drugs for their effectiveness in killing the malaria-causing parasite and found that astemizole was one of the more promising.

The researchers then gave astemizole, along with the drug’s major human metabolite, desmethylastemizol, to mice infected with Plasmodium. They measured 80 percent reduction in parasite counts with moderate doses of drug in
'"/>




Page: 1 2

Related medicine news :

1. Nasal Spray Beats Antihistamine
2. Antihistamine Proved Ineffective in Making Kids to Sleep
3. Travelers’ Hazard- Antihistamines Make Drowsy Driver
4. Lean Protein Could Be Key to Obesity Drugs
5. Nasal Spray Could Take Drugs Direct to Brain.
6. Nasal Spray Could Take Drugs Directly to Brain
7. Oxygen Usage During Exercise Could Indicate Heart Problems
8. Ultrasound Screening Could Improve The Outcome Of Critically ill Patients
9. Anger Could Be Linked To Weight Gain
10. A Seizure Late In Life Could be A Stroke Warning
11. New Findings Could Reduce The Extent Of Spinal Cord Injuries
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Antihistamine Could also used Potential Antimalarial Drug

(Date:5/24/2015)... A report out just last month ... option for avoiding cardiovascular disease is exercise and maintaining ... single most powerful predictor of death and survival, even ... family history of premature death -- a finding that ... fitness. , The Importance of Cardiovascular Screening , The ...
(Date:5/23/2015)... Dr. David Benvenuti, an experienced plastic surgeon who practices ... article to his website that takes an in-depth look ... in the fascinating blog, he has recently had several young ... as “gauging,” the technique involves placing larger and larger gauge ... eventually stretch the holes out to incredible sizes. As the ...
(Date:5/23/2015)... On May 16, the team at Farrell’s ... 5k mud obstacle run that raised funds for multiple sclerosis. ... and the reason we participated was to support people living ... Farrell’s eXtreme Bodyshaping. “One-hundred percent of the funds raised go ... was not only attended by eXtreme Bodyshaping staff, but members ...
(Date:5/23/2015)... May 23, 2015 Javon Bea ... the Sports Medicine and Rehabilitation Center, 557 N. Washington ... Mondays, June 1-July 20, 5:30-6:30 pm. , The 8-week ... and Laurie Finke, RN, BSN, who will offer training ... on nutrition, running mechanics and show selection and weekly ...
(Date:5/22/2015)... Pasadena, Calif. (PRWEB) May 22, 2015 ... where technology, communication and capacity are intersecting to ... and across society, the opening speaker at WesternU's ... , California Lieut. Gov. Gavin Newsom, a former ... was the keynote speaker at the graduation ceremony ...
Breaking Medicine News(10 mins):Health News:Recent Mayo Clinic Studies Help to Highlight the Value of Cardio Testing 2Health News:Recent Mayo Clinic Studies Help to Highlight the Value of Cardio Testing 3Health News:Dr. Benvenuti, a Plastic Surgeon in Newport Beach, CA, Posts New Article about Repairing Ear Gauges 2Health News:Farrell’s eXtreme Bodyshaping Team Runs through the Muck for MS 2Health News:Newsom to WesternU Grads: The Future is Inside You 2Health News:Newsom to WesternU Grads: The Future is Inside You 3
... BioForm Medical,Inc. (Nasdaq: BFRM ) announced that ... 30, 2007 first quarter fiscal year 2008 financial,results. The ... NASDAQ,Global Market closes and will hold a conference call ... Time)., BioForm Chief Executive Officer Steve Basta and ...
... Activists Awarded Three-Year $5.2,Million Grant, SAN FRANCISCO, ... of the International Treatment Preparedness Coalition,and Tides, announced ... for $5.2,million from the Bill & Melinda Gates ... in advocacy and educational,activities to increase access to ...
... National partners,from the 16th annual Halloween Promotion benefiting ... million of the projected $4.8,million donation to the ... cancer. Companies represented at the check presentation included,A&P ... Store, Fox,& Hound, Hess Corporation, Petro Stopping Centers, ...
... to Kids Across the U.S.,on World Allergy Day, ... largest,allergy patient advocacy organization in the world, the ... holidays a little brighter for,children coast-to-coast who are ... by donating over 1,000 certified asthma &,allergy friendly(TM) ...
... themselves can raise their aspirations, motivation and accomplishments,and are ... do them., So says Albert Bandura, a Stanford ... the 2008 University of Louisville,Grawemeyer Award for Psychology. He ... 31 nominations from five countries., Bandura,s ideas have ...
... Dec. 4 Mylan Inc. (NYSE: MYL ... tentative,approval from the U.S. Food and Drug Administration ... (PEPFAR) for its Abbreviated New,Drug Application (ANDA) for ... Fumarate is the first and only generic,tentative approval ...
Cached Medicine News:Health News:BioForm to Announce First Quarter Fiscal 2008 Financial Results and Host Conference Call and Webcast on December 13, 2007 2Health News:HIV Collaborative Fund Receives Gates Foundation Grant for AIDS Treatment and Prevention Advocacy 2Health News:HIV Collaborative Fund Receives Gates Foundation Grant for AIDS Treatment and Prevention Advocacy 3Health News:National Partners from St. Jude Halloween Promotion Presents More Than $1.7 Million to Help Fight Childhood Cancer 2Health News:Allergy Foundation Thinks Globally, Gifts Locally 2Health News:Self-Confidence Can Make Us Better, Says Grawemeyer Psychology Winner 2Health News:Mylan Announces Tentative FDA Approval Under PEPFAR for Tenofovir Disoproxil Fumarate Tablets 2
(Date:5/22/2015)... NEW YORK , May 22, 2015 /PRNewswire/ ... approval of Zarxio (filgrastim-sndz) -- the first biosimilar ... -- points toward growth in the ... Information. The mainstream CMO industry is geared to ... infrastructure to produce major biopharmaceutical products. The healthcare ...
(Date:5/22/2015)...  The Mesothelioma Victims Center is incredibly passionate ... the best possible compensation, and they are also extremely ... cancer caused by exposure to asbestos or their ... treatment options such as a recent possible medical breakthrough. ... Center anytime at 866-714-6466. http://MesotheliomaVictimsCenter.Com ...
(Date:5/22/2015)... 2015   InspireMD, Inc. (NYSE MKT: NSPR) ("InspireMD" ... ("EPS"), today announced that its CGuard TM Embolic Prevention ... Prof. Piotr Musialek , at the EuroPCR ... . PARADIGM, an investigator-initiated P rospective ... roti D revascularization I n symptomatic and increased-risk ...
Breaking Medicine Technology:Kalorama: First FDA-Approved Biosimilar Brings Hope for CMO Growth 2Kalorama: First FDA-Approved Biosimilar Brings Hope for CMO Growth 3Kalorama: First FDA-Approved Biosimilar Brings Hope for CMO Growth 4Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 2Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 3Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 4Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 5InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 2InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 3InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 4
... the results and outcomes of ocular ... clues to diagnosing and managing ocular ... properties of corneal tissue has not ... to measuring purely geometrical aspects of ...
Diamond Reusable Probed work with all ACMI™ instrument inserts. Dual trumpet valves provide smooth, effective fingertip control over suction and irrigation....
... Tear Pool punctum plugs. Tear Pool punctum plugs ... with no additives via a precision molding process. ... which is designed to facilitate insertion as well ... position in the punctum. The cap of the ...
... performance ultrasound design provides unique advantages ... imaging requires superior spatial resolution, high ... The Terason Echo Ultrasound System, based ... a compact imaging platform without sacrificing ...
Medicine Products: