Navigation Links
Antihistamine Could also be used as a Potential Antimalarial Drug

Researchers have found that astemizole, which is used for treating allergy can also be used as a potential drug for treating malaria//.

According to a study conducted by researchers from the Johns Hopkins Bloomberg School of Public Health and the Johns Hopkins University School of Medicine. The study, largely funded by the Johns Hopkins Malaria Research Institute (MRI), determined that in a test tube the antihistamine killed the parasite, Plasmodium falciparum, which causes malaria in humans, including parasite strains that were resistant to traditional malaria therapies. The drug was also shown to be effective in mouse models. The findings are published in the July 2, 2006, advanced online edition of Nature Chemical Biology.

“Time and money are major roadblocks when it comes to developing new drugs for the treatment of neglected diseases like malaria,” said senior study author David Sullivan, MD, an associate professor with MRI and the Bloomberg School’s W. Harry Feinstone Department of Molecular Microbiology and Immunology. “Astemizole is promising as an antimalarial, but still needs to be evaluated for effectiveness as an antimalarial in humans.”

For the study, Sullivan and colleagues Curtis Chong and Jun Liu of the Johns Hopkins School of Medicine’s Department of Pharmacology first assembled the Johns Hopkins Clinical Compound Library, which is a collection of 2,687 drugs. Seventy percent of the compounds are approved by the U.S. Food and Drug Administration, while the remaining 30 percent are approved by regulatory agencies in other countries. The researchers screened the drugs for their effectiveness in killing the malaria-causing parasite and found that astemizole was one of the more promising.

The researchers then gave astemizole, along with the drug’s major human metabolite, desmethylastemizol, to mice infected with Plasmodium. They measured 80 percent reduction in parasite counts with moderate doses of drug in chloroquine-sensitive mice and 40 percent reductions in chloroquine-resistant mice. Higher doses completely eliminated Plasmodium infection.

Astemizole was voluntarily withdrawn from the U.S. and European markets in 1999 after 15 years of use when sales became sluggish after warnings about the drug’s safety and the introduction of newer antihistamines. The drug was reported to cause rare, but life-threatening heart arrhythmias when patients took an overdose or with drugs that affected its metabolism. However, arrhythmias are also reported with existing malaria drugs and other antihistamines now sold over the counter. Astemizole is currently still used in 30 countries, including Cambodia, Thailand and Vietnam where malaria is endemic.

Human studies are planned to evaluate the effectiveness of astemizole directly in asymptomatic malaria patients, a process that will be accelerated by the fact that the medication has been through an approval process. The researchers hope to next validate this new drug class for use in combination with existing malaria drugs like artemisinin or the quinolines.

The Johns Hopkins Clinical Compound Library will now be available to screen existing drugs for new uses for diseases affecting the developing world. “This line of research can be applied to many neglected diseases,” said Chong, the lead author of the study.

(Source: Nwswise)
'"/>




Related medicine news :

1. Nasal Spray Beats Antihistamine
2. Antihistamine Proved Ineffective in Making Kids to Sleep
3. Travelers’ Hazard- Antihistamines Make Drowsy Driver
4. Lean Protein Could Be Key to Obesity Drugs
5. Nasal Spray Could Take Drugs Direct to Brain.
6. Nasal Spray Could Take Drugs Directly to Brain
7. Oxygen Usage During Exercise Could Indicate Heart Problems
8. Ultrasound Screening Could Improve The Outcome Of Critically ill Patients
9. Anger Could Be Linked To Weight Gain
10. A Seizure Late In Life Could be A Stroke Warning
11. New Findings Could Reduce The Extent Of Spinal Cord Injuries
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... 2016 , ... Quality metrics are proliferating in cancer care, and are derived ... eye of the beholder, according to experts who offered insights and commentary in the ... Care. For the full issue, click here . , For the American Society ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... ... fertility once they have been diagnosed with endometriosis. These women need a treatment ... also require a comprehensive approach that can help for preservation of fertility and ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency ... named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. ... Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... are unfamiliar with. The article goes on to state that individuals are now more ... these less common operations such as calf and cheek reduction. The Los Angeles area ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are recognized ... this recognition are considered among the top 2 percent of lawyers practicing within the ... this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, Burt ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Research ... World Market for Companion Diagnostic Tests" report to their ... Market for Companion Diagnostics The World Market ... and personalized medicine diagnostics. Market analysis in the report includes ... Test Market (In Vitro Diagnostic Kits) by Region (N. America, ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
(Date:6/23/2016)... June 23, 2016 Roche (SIX: RO, ROG; ... for its Elecsys BRAHMS PCT (procalcitonin) assay as a ... septic shock. With this clearance, Roche is the first ... integrated solution for sepsis risk assessment and management. ... infection and PCT levels in blood can aid clinicians ...
Breaking Medicine Technology: