Navigation Links
Anticancer Effects of Curcumin Revealed

Curry powder is a mixture predominantly composed of turmeric root extract and other spices such as coriander and fenugreek. //

Curcumin, a turmeric root extract, has been shown to possess activity in the treatment and prevention of cancer, multiple sclerosis, and Alzheimer's disease. The molecular mechanism for its anticancer effect is largely unknown, although it is thought to inhibit the synthesis of MDM2, an oncoprotein known to bind p53 and modulate p21 expression.

In the issue of Cancer Research, Li and colleagues from the Comprehensive Cancer Center of the University of Alabama report on a study designed to elucidate the molecular anticancer effect of curcumin in a preclinical prostate cancer model.

Using PC-3 human prostate cancer cell lines grown in vitro, curcumin was found to decrease the mRNA and protein expression of the oncoprotein MDM2 and to enhance the expression of tumor modulator p21. This translated into an induction of apoptosis and inhibition of proliferation of PC-3 cells grown in culture.

A group of mice xenografts were also developed using the PC-3 cell-line. Curcumin was administered via an oral route to all mice (5 days per week for 4 weeks) except for the control group which only received cottonseed oil. Study groups (5 mice each) were divided as follows: (1) curcumin therapy alone, (2) gemcitabine alone intraperitoneally, (3) radiotherapy alone, and (4) control. Tumor mass was compared at the end of the study. Compared to the control, in all study groups curcumin was found to inhibit the growth of tumors in mice and to enhance the effects of both gemcitabine therapy and radiation therapy.

This well-performed study provides an elegant mechanistic explanation for the anticancer effect of curcumin, which appears to act in a p53 independent manner. These exciting data suggest that this dietary supplement should be studied in combination with traditional forms of chemotherapy or radio therapy in tumors dependent on the MDM2 pathway.

Source-IANS
'"/>




Related medicine news :

1. Anticancer Properties of Vitamin D Could Be Separated From Other Functions
2. Anticancer Properties of Vitamin D Revealed
3. GSK’s New Anticancer Drug A Huge Success In Drug trail
4. Acupuncture May Help Chemotherapy Side Effects
5. Chemotherapy Pill Has Fewer Side Effects Than IV
6. Therapy Boosts Chemotherapy Effects
7. Smoking and its Effects
8. Reducing The After Effects of Tonsillectomy
9. The Side Effects Of Estrogen Therapy
10. The Harmful Effects Of Cigarette Smoke
11. Lung Therapy Found To Have Long-Term Side Effects
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... , ... June 25, 2016 , ... ... and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a ... area —Johnson is one of the first doctors to perform the treatment. Orthobiologics ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits ... terms of the latter, setting the bar too high can result in disappointment, perhaps ... slow progress toward their goal. , Research from PsychTests.com reveals that ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set ... drug or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, ... traumatic event. , Trauma sufferers tend to feel a range of emotions, from depression, ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. ... The attorneys chosen by their peers for this recognition are considered among the top ... Shareholders received special honors as members of this year’s Legal Elite Hall of Fame: ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... report to their offering. ... kidney failure, it replaces the function of kidneys by removing ... thus the treatment helps to keep the patient body,s electrolytes ... Increasing number of ESRD patients & substantial healthcare expenditure ...
(Date:6/23/2016)... , June 23, 2016  In a startling report released ... failing their residents by lacking a comprehensive, proven plan to eliminate ... a definitive ranking of how states are tackling the worst drug ... only four states – Kentucky , ... Vermont . Of the 28 failing states, three – ...
Breaking Medicine Technology: