Navigation Links
Anticancer Effects of Curcumin Revealed

Curry powder is a mixture predominantly composed of turmeric root extract and other spices such as coriander and fenugreek. //

Curcumin, a turmeric root extract, has been shown to possess activity in the treatment and prevention of cancer, multiple sclerosis, and Alzheimer's disease. The molecular mechanism for its anticancer effect is largely unknown, although it is thought to inhibit the synthesis of MDM2, an oncoprotein known to bind p53 and modulate p21 expression.

In the issue of Cancer Research, Li and colleagues from the Comprehensive Cancer Center of the University of Alabama report on a study designed to elucidate the molecular anticancer effect of curcumin in a preclinical prostate cancer model.

Using PC-3 human prostate cancer cell lines grown in vitro, curcumin was found to decrease the mRNA and protein expression of the oncoprotein MDM2 and to enhance the expression of tumor modulator p21. This translated into an induction of apoptosis and inhibition of proliferation of PC-3 cells grown in culture.

A group of mice xenografts were also developed using the PC-3 cell-line. Curcumin was administered via an oral route to all mice (5 days per week for 4 weeks) except for the control group which only received cottonseed oil. Study groups (5 mice each) were divided as follows: (1) curcumin therapy alone, (2) gemcitabine alone intraperitoneally, (3) radiotherapy alone, and (4) control. Tumor mass was compared at the end of the study. Compared to the control, in all study groups curcumin was found to inhibit the growth of tumors in mice and to enhance the effects of both gemcitabine therapy and radiation therapy.

This well-performed study provides an elegant mechanistic explanation for the anticancer effect of curcumin, which appears to act in a p53 independent manner. These exciting data suggest that this dietary supplement should be studied in combination with traditional forms of chemotherapy or radio therapy in tumors dependent on the MDM2 pathway.

Source-IANS
'"/>




Related medicine news :

1. Anticancer Properties of Vitamin D Could Be Separated From Other Functions
2. Anticancer Properties of Vitamin D Revealed
3. GSK’s New Anticancer Drug A Huge Success In Drug trail
4. Acupuncture May Help Chemotherapy Side Effects
5. Chemotherapy Pill Has Fewer Side Effects Than IV
6. Therapy Boosts Chemotherapy Effects
7. Smoking and its Effects
8. Reducing The After Effects of Tonsillectomy
9. The Side Effects Of Estrogen Therapy
10. The Harmful Effects Of Cigarette Smoke
11. Lung Therapy Found To Have Long-Term Side Effects
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2017)... ... May 28, 2017 , ... Viewers likely know Rob Lowe from such ... also noted for his work on NBC’s The West Wing and Parks and Recreation. ... new series “Informed,” which puts the spotlight on important modern-day issues that face today’s ...
(Date:5/27/2017)... ... May 27, 2017 , ... From May 21-23, hearing healthcare ... three-day event was held at the Marriott Syracuse Downtown Hotel in Syracuse, New York. ... and network of independent hearing healthcare providers to help them stay ahead in the ...
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... ... gather at Boston CEO 2017 on May 30th and 31st at The Four ... forum for leading executives in the life sciences, offering exclusive access to key ...
(Date:5/26/2017)... ... May 26, 2017 , ... A new analysis of community health data ... are located in the Midwest. With the average cost of healthcare rising and the ... with both the quality and affordability of where they live. An annual 2017 report ...
(Date:5/26/2017)... ... May 26, 2017 , ... After raising nearly $30,000 on ... will continue to be available at a discounted crowdfunding price on Indiegogo . ... they are, I also wanted to bring a fidget toy to the market that ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... 2017 Zimmer Biomet Holdings, Inc. (NYSE and ... announced it has earned a spot on Forbes, ... Company was ranked among 500 U.S. employers as well ... Equipment and Services. The annual Forbes ... independent survey of over 30,000 employees across 25 industries. ...
(Date:5/9/2017)... 2017  Semler Scientific, Inc. (OTCQB: SMLR), an ... improve the clinical effectiveness and efficiency of healthcare ... quarter ended March 31, 2017. ... to identify when preventive care options are appropriate, ... heart attacks or strokes occur," said Doug ...
(Date:5/6/2017)... , May 5, 2017   Provista , a ... more than 200,000 customers, today announced Jim Cunniff ... wealth of executive and business experience to Provista, including most ... pharmacy in California . He assumed his ... "Jim is a great fit for Provista," says Jody ...
Breaking Medicine Technology: