Navigation Links
Antibodies in Mother Affect Heart of Fetus

A study conducted in 100 pregnant women with anti-Ro and anti-La antibodies revealed development of heart problems in fetus that could be treated in early stages//.

There is an increased risk of fetal heart problems when mothers carry particular antibodies associated with rheumatic diseases, according to an abstract presented by Yale School of Medicine researchers at the Society for Maternal-Fetal Medicine Conference February 9 in San Francisco.

Congenital heart block (CHB) is present at or before birth and impairs the heart's electrical signaling from the upper to the lower chambers. CHB carries a 20 percent death rate and nearly all survivors require pacemakers. Joshua Copel, M.D., professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale helped conduct the PR Interval and Dexamethasone Evaluation (PRIDE) study with a team of other researchers to evaluate an early marker of cardiac injury before there is permanent scarring.

The PRIDE group conducted a longitudinal (observational) study following over 100 women with the anti-Ro and anti-La antibodies to determine if there were early signs of fetal heart problems. They also explored whether early treatment would reverse the problems.

The team found that while first-degree fetal heart block may be reversible with the steroid drug dexamethasone, the condition could advance within as little as one week to a third-degree block, which is irreversible even with further intervention.

"Given the high recurrence rate we confirmed in this study, close monitoring and the earliest possible marker is necessary," said Copel, who plans trials of other possible treatments. "Advanced block and permanent heart damage can occur within one week of a normal echocardiogram, even a weekly evaluation may not be sufficient to detect early onset of disease."


Page: 1

Related medicine news :

1. Antibodies to fight HIV infection.
2. Heparin Antibodies May Put Patients At Risk
3. Survival of Mice With Human Breast Cancer Extended by Monoclonal Antibodies
4. Scientists Develop Antibodies from Plant Seeds
5. Mothers with periodontitis may deliver premature babies
6. Changing Partners may put Expectant Mothers at Risk
7. Link Between Mothers Depression and Violence in Children
8. Drug to stop HIV spread to babies may Indirectly harm The Mother
9. Mother’s Diet Could Prevent Cancer In Their Unborn Children
10. Mother’s Milk Stored For Long Periods Found To Have Less Antioxidant
11. Vaginal Birth After C-section Dangerous For Both Mother And Baby
Post Your Comments:

(Date:12/1/2015)... ... ... is the first health care provider in the region to offer the vBloc® Therapy ... vagal blocking therapy, delivered via the Maestro® System, for the treatment of adult patients over ... to 45 kg, or a BMI of at least 35 to 39.9 kg with a ...
(Date:12/1/2015)... ... December 01, 2015 , ... Dr. Paul Vitenas, one of the ... been named by MedEsthetics magazine as the Best Single Physician Practice in the nation. ... many elite aesthetic physicians honored by the industry publication. , Dr. Vitenas said ...
(Date:12/1/2015)... Delaware (PRWEB) , ... December 01, 2015 , ... ... winner at the 7th Annual 2015 Golden Bridge Business Awards under the New ... is a zero capex web based sample management software that helps ...
(Date:12/1/2015)... ... 2015 , ... For many X-rays taken at hospitals, doctors’ ... by the radiologist. The marking utensils are so small, however, they are difficult ... way to alleviate this problem. , He developed the patent-pending MARK N SHOW ...
(Date:12/1/2015)... ... December 01, 2015 , ... ... it has been awarded a fixed price per sprint agile development contract to ... at $34 million over five years, provides software engineering, infrastructure, as well as ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... Pa. , Dec. 1, 2015  Today, ... announced the launch of CareFront, a first-of-its-kind population ... patients diagnosed with cancer. Designed to be built ... diagnosed cancer patients with resources for their care ... The program also offers tools to help patients ...
(Date:12/1/2015)... , Dec. 1, 2015   Craneware, ... value cycle solutions, today announced the company will ... Pharmacy ChargeLink ® solution at the ... Midyear Clinical Meeting . The new features are ... process of monitoring and managing enterprise-wide pharmacy charges ...
(Date:12/1/2015)... 1, 2015  Booth #3506 – Claymount is featuring its ... meeting of the Radiological Society of North America ... year. Based in the Netherlands , Claymount ... Systems (NYSE: VAR ) and is one of the ... solid state automatic exposure control systems for controlling dose during ...
Breaking Medicine Technology: