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Antibiotics help combat dangerous tropical disease

was re-examined at eight months. At fourteen months after being treated with doxycyclin the doctors were only able to detect the typical movements of the worms (the dance of the filariae) on ultrasound in one in five patients. In the placebo group the rate was 89%.

"The importance of these findings for therapy should not be underestimated," Professor H?rauf emphasizes. "The mature worms are after all responsible for such symptoms of the disease as the extreme swelling of the limbs. In the past there was no effective and reliable method of combating them." The effectiveness of the antibiotic might be even greater than what was measured: "we cannot exclude the possibility that several patients became re-infected in the months following treatment with doxycyclin. It is therefore quite possible that all the worms were killed and the remaining 20% are the result of re-infection, which would no longer occur if infection was effectively prevented.

Doxycyclin has been used a safe and cheap drug and has been around for many years. however a note of caution is warranted when it is used in children. In them it may cause irreparable damage to the teeth and slow down growth of the bones. The antibiotic should not be used also during pregnancy. The drug is harmless in adults and adolescents. "Its biggest advantage is that it is already licensed for medical use," Professor H?rauf points out. "Elephantiasis hits the poor most of all. It is therefore not likely that the pharmaceuticals industry will develop completely new drugs."

Reference: The Lancet (vol. 365, May 2005).
Contact: Professor Achim H?rauf
hoerauf@parasit.meb.uni-bonn.de
49-228-287-5673
University of Bonn
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