Navigation Links
Antibiotics help combat dangerous tropical disease

More than 120 million people worldwide suffer from Filarial infection and some// get grotesque condition called elephantiasis, where their legs resemble that of an Elephant. The condition is caused by a pathogen called wuchereria bancrofti, this is a threadlike worm They go and house themselves in the body’s lymph nodes where they cause the blockage of the flow of lymphatic fluids and cause swelling of an organ like the legs or genitalia like the scrotum, penis or vulva.

The adult wuchereria worms have a lifespan of up to five years. And during this time they produce millions of offspring known as microfilariae. These micro-filarae from an infected patient find themselves infecting another person when the mosquito has another go at the blood pf these individuals. Once in the blood circulation they mature into adult worm and settle in their lymph nodes and the cycle keeps repeating.

"Although the drugs currently in use kill the micro-filariae, they largely leave the adult worms unscathed," Bonn parasitologist Professor Achim H?rauf explains. "Due to the long lifespan of the wuchereria worms, therapy lasts several years, during which time the symptoms continue to persist." The drug to treat the micro-filariae can also cause severe side-effects.

In an interesting find it was realized that the filarial threadworm is dependant on a bacteria to survive and if the bacteria is killed the worm also will die. "This is why wuchereria is susceptible to antibiotics which are normally used against bacterial infections," said Professor H?rauf emphasizes. In their study in Tanzania they treated 72 male patients for eight weeks with doxycyclin or a placebo.

What they found was that initially the patients blood was swarming with micro-filariae and the researchers counted on an average up to 1,300 of them per milliliter of blood. However in patients treated with doxycylin the micro-filariae had almost completely disappeared when the blood was re-examined at eight months. At fourteen months after being treated with doxycyclin the doctors were only able to detect the typical movements of the worms (the dance of the filariae) on ultrasound in one in five patients. In the placebo group the rate was 89%.

"The importance of these findings for therapy should not be underestimated," Professor H?rauf emphasizes. "The mature worms are after all responsible for such symptoms of the disease as the extreme swelling of the limbs. In the past there was no effective and reliable method of combating them." The effectiveness of the antibiotic might be even greater than what was measured: "we cannot exclude the possibility that several patients became re-infected in the months following treatment with doxycyclin. It is therefore quite possible that all the worms were killed and the remaining 20% are the result of re-infection, which would no longer occur if infection was effectively prevented.

Doxycyclin has been used a safe and cheap drug and has been around for many years. however a note of caution is warranted when it is used in children. In them it may cause irreparable damage to the teeth and slow down growth of the bones. The antibiotic should not be used also during pregnancy. The drug is harmless in adults and adolescents. "Its biggest advantage is that it is already licensed for medical use," Professor H?rauf points out. "Elephantiasis hits the poor most of all. It is therefore not likely that the pharmaceuticals industry will develop completely new drugs."

Reference: The Lancet (vol. 365, May 2005).
Contact: Professor Achim H?rauf
hoerauf@parasit.meb.uni-bonn.de
49-228-287-5673
University of Bonn
'"/>




Related medicine news :

1. Antibiotics Dangerous for Diarrhoea in Children Caused by E.Coli
2. Antibiotics Helps Autism
3. Antibiotics losing their power against acne
4. Antibiotics help heart patients
5. Antibiotics May Help Prevent Strokes
6. Antibiotics Found To Increase The Risk Of Developing Breast Cancer
7. Antibiotics Overload For Kids Questioned
8. The Use Of Antibiotics Questioned
9. The Dangers Of Prescribing Antibiotics
10. Eliminating Eye Infection With Antibiotics
11. Eliminating Eye Infection With Antibiotics
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... ... Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with clinical associate ... primary prevention of cardiovascular diseases during the 15th Annual Women’s Health Conference. ...
(Date:10/13/2017)... , ... October 13, 2017 , ... The Visiting Nurse ... Market. Featuring a collection of specialty vendors and unique items from across the nation, ... quality-focused health and wellness services offered by the VNA. The boutique will be ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, ... lowdown on sciatica in a new episode of "Success Files," which is an ... and innovation and investigates each subject in-depth with passion and integrity. , Sciatica ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance ... management, will showcase a range of technology and learning solutions at the 68th ... and Expo to be held October 14–18, 2017 at the Mandalay Bay Resort ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ... introduction of an innovative new design of the shoulder pad. The shoulder pad ... comfort while controlling your pain while using cold therapy. By utilizing ice and water ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Oct. 2, 2017 The Rebound mobile app is ... to reverse the tide of prescription drug addiction. The app ... medicine intake and stepping down their dosage in a safe, ... in December 2017; the first 100,000 people to sign up ... http://www.rebound-solution.com/ ...
(Date:9/27/2017)... 27, 2017  Commended for their devotion to personalized service, ... as number one in the South Florida Business Journal,s 50 ... 5000 yearly list, the national specialty pharmacy has found its ... will soon be honored by SFBJ as the 2017 ... Set to receive his award in October, Bardisa said ...
(Date:9/25/2017)... PROVIDENCE, R.I. , Sept. 25, 2017 /PRNewswire/ ... immunogenicity assessment, vaccine design, and immune-engineering today announced ... focused on the development of personalized therapeutic cancer ... and has provided exclusive access to enabling technologies ... MSc Eng., MBA will lead EpiVax Oncology as ...
Breaking Medicine Technology: