Navigation Links
Antibiotic Proved Protective against Heart Tissue Damage and Cell Death – Research Find

Antibiotics - decreased cell death and heart attack injury by maintaining Adenosine Tri Phosphate (ATP) levels in the cells//.

A study with rapamycin - an antibiotic (used to trigger organ survival in transplant patients) by Virginia Commonwealth University researchers have revealed that heart tissue damage after an acute heart attack might be protected by rapamycin.

In the July issue of the Journal of Molecular and Cellular Cardiology, the official publication of the International Society for Heart Research, researchers demonstrated for the first time that pretreatment with a clinically relevant dose of rapamycin induces a protective effect against heart attack injury and reduces programmed cell death.

Researchers believe through the opening of the mitochondrial KATP channel of heart cells, rapamycin enables cells to maintain ATP levels. Mitochondria are cellular organelles critical for converting oxygen into ATP, the key fuel for cellular function.

‘Rapamycin may one day be beneficial as a potential therapeutic strategy to limit cell death caused by ischemia or reperfusion injury, and possibly long-term prevention of ventricular remodeling – the changes in size, shape and function that may occur to the left ventricle of the heart,’ said Rakesh C. Kukreja, Ph.D., professor of medicine and Eric Lipman Chair of Cardiology at VCU. Kukreja is lead author of the study.

Rapamycin blocks protein synthesis by inhibiting the mammalian target of rapamycin (mTOR), an essential component in the pathway of the cell cycle progression. The drug has been found to be important in transplant medicine and especially in kidney or heart transplantation. Additionally, Kukreja said that because of the antibiotic’s antigrowth properties, rapamycin effectively reduces coronary restonosis, the abnormal narrowing of a blood vessel. In coronary angioplasty, stents coated with rapamycin are implanted to reduce the risk of restonosis.

‘A significant clinical question will be whether or not rapamycin coated stents can be utilized in patients to favorably affect damaged heart muscle beyond the blockage causing a heart attack,’ said George W. Vetrovec, M.D., chair of cardiology at VCU’s School of Medicine, and co-author of the study.

For the last several years, Kukreja and his colleagues have studied a class of erectile dysfunction drug known as phosphodiesterase-5 inhibitors as part of ongoing research into heart protection. The team first investigated Viagra?, generically known as sildenafil, and more recently, Levitra?, generically known as vardenafil, and found that both compounds showed protective effects in the heart during experimental heart attacks in animal models.

This work was supported by grants from the National Institutes of Health, and American Heart Association, National Center.

Source: Eureklert
'"/>




Related medicine news :

1. Antibiotics Dangerous for Diarrhoea in Children Caused by E.Coli
2. Antibiotics Helps Autism
3. Antibiotics losing their power against acne
4. Antibiotic induces liver damage in children with E.COLI infections.
5. Antibiotics help heart patients
6. Antibiotics May Help Prevent Strokes
7. ICU Survival can be improved by Antibiotic use
8. Antibiotics Found To Increase The Risk Of Developing Breast Cancer
9. Antibiotics Overload For Kids Questioned
10. The Use Of Antibiotics Questioned
11. The Dangers Of Prescribing Antibiotics
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/29/2016)... , ... April 29, 2016 , ... ... of a growth round of funding led by Eastside Partners, with participation from ... company’s rapidly growing customer base and accelerate its technology and product roadmap. ...
(Date:4/29/2016)... ... ... Nike Softball Camp at the College of Brockport in New York is ... 10-18. All facets of the game will be covered; hitting, fielding, base-running, and team ... the finest softball facilities in the region. The outstanding professional college staff complement and ...
(Date:4/29/2016)... ... 29, 2016 , ... Intellitec Solutions is pleased to announce ... GP for one their long-term care clients. Working together with the clients staff, ... clinical management systems, and delivered a fully integrated accounting and business-management solution that ...
(Date:4/29/2016)... ... 2016 , ... The number of chronically and seriously ill individuals is growing. ... an urgent need for highly skilled care managers and care coordinators. Care ... train and retain care managers, and enhance their skills. , Care Excellence ...
(Date:4/28/2016)... ... 2016 , ... The Dentists Insurance Company (TDIC), ... letter of intent with Moda to acquire Dentists Benefits Insurance Company ... by dentists 36 years ago, TDIC focuses exclusively on supporting the dental profession ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... 28, 2016 Dr. Vivek Ahuja ... and Ste phen Schmidt ... leading provider of cloud-based software solutions for life sciences, today announced ... bring a wealth of insight to a growing business.  This will ... George Phillips joined ArisGlobal in the position of ...
(Date:4/28/2016)... Florida , April 28, 2016 ... the development of innovative peptide and gene-based immunotherapeutics and vaccines ... it will be presenting at the 3rd Annual Growth ... - 5 th , 2016 at Caesars Palace in Las Vegas, ... 8.00 am on Wednesday, May 4 th by Dr. ...
(Date:4/27/2016)... 27 Avril 2016   ... de +5% sur le trimestre, soutenu par une ... Croissance de +16% des ventes aux ... Mauna Kea Technologies (Euronext : MKEA, FR0010609263 ; OTCQX : MKEAY), ... annonce aujourd,hui son chiffre d,affaires pour le premier ...
Breaking Medicine Technology: