Navigation Links
Antibiotic Inhibits Cancer Gene Activity

A little-known antibiotic shows early promise as an anti-cancer agent, inhibiting a gene found at higher-than-normal levels in most human tumors, // according to researchers at the University of Illinois at Chicago College of Medicine.

Their findings appear in the Oct. 1 issue of Cancer Research.

"We chose to target a gene believed to be over-expressed in cancer cells to screen for promising anti-cancer agents," said Andrei Gartel, assistant professor of medicine and of microbiology and immunology at UIC and principal investigator on the study.

The FoxM1 gene is responsible for turning on genes needed for cell proliferation and turning off genes that block proliferation. Uncontrolled proliferation is characteristic of cancer cells.

The researchers developed a new screening system, based on a naturally fluorescent protein called luciferase, to identify small molecules that inhibit proteins that turn genes on and off. Using this system, they identified an antibiotic, siomycin A, that specifically targets FoxM1 without affecting other cell functions.

In further experiments in tissue cultures, the researchers found that siomycin A induced cancer cells, but not normal cells, to commit suicide in a process called apoptosis.

The new screening technique, Gartel said, gives researchers a rapid way to find agents that target oncogenes -- genes believed to cause cancer. He said siomycin A, the first compound found with the method, "is particularly promising because we know that it is not toxic."

Siomycin A must now be tested against other cell lines in the laboratory and in preliminary animal experiments before human trials could be planned. Only a tiny fraction of promising candidate drugs enter clinical trials, and few of those are ever approved.

Gartel said the participation of the late Robert Costa, professor of biochemistry and molecular genetics at UIC and a leader in research on FoxM1, was critical for the success of the project thus far.

Senthil Radhakrishnan, a visiting bioinformatics expert at UIC, is first author of the paper. Uppoor Bhat, Douglas Hughes and I-Ching Wang also contributed to the study.

The research was supported by the 2006 Penny Severns Award from the Illinois Department of Public Health, the UIC Department of Medicine and the U.S. Public Health Service.

UIC ranks among the nation's top 50 universities in federal research funding and is Chicago's largest university with 25,000 students, 12,000 faculty and staff, 15 colleges and the state's major public medical center. A hallmark of the campus is the Great Cities Commitment, through which UIC faculty, students and staff engage with community, corporate, foundation and government partners in hundreds of programs to improve the quality of life in metropolitan areas around the world.

Source-Newswise
'"/>




Related medicine news :

1. Antibiotics Dangerous for Diarrhoea in Children Caused by E.Coli
2. Antibiotics Helps Autism
3. Antibiotics losing their power against acne
4. Antibiotic induces liver damage in children with E.COLI infections.
5. Antibiotics help heart patients
6. Antibiotics May Help Prevent Strokes
7. ICU Survival can be improved by Antibiotic use
8. Antibiotics Found To Increase The Risk Of Developing Breast Cancer
9. Antibiotics Overload For Kids Questioned
10. The Use Of Antibiotics Questioned
11. The Dangers Of Prescribing Antibiotics
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/5/2016)... ... ... For many years, Andrew G. Zubinas has accumulated over 130 hardcover ... Lithuanian language and its poetry inspired him in writing “ Forest Lungs ... aspects of a living, breathing forest where nothing ever stays the same. His subjects ...
(Date:12/5/2016)... ... December 05, 2016 , ... ... announced today that nominations will be accepted from December 5, 2016 through ... , Awards include the Information Security Executive® of the Year, which recognizes ...
(Date:12/5/2016)... ... December 05, 2016 , ... Worldwise ... global lifestyle design firm kathy ireland® Worldwide for five additional years, announced by ... into an exclusive licensing agreement three years ago to design and develop the ...
(Date:12/5/2016)... ... December 05, 2016 , ... Progressive ... of L-Citrulline and glutathione to enhance production of nitric oxide (NO). , NitroGenesis ... shown to produce NO twice as effectively and sustains NO blood levels twice ...
(Date:12/5/2016)... ... December 05, 2016 , ... ICA, ... alerting technology to Central Illinois Health Information Exchange (CIHIE) using its Smart ... as the sole sub-recipient participating with the Illinois Health Information Exchange Authority ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... According to a new market research report "Cartilage Repair/ ... Tissue Scaffolds, Cell-free composites), Application (Hyaline Cartilage, Fibrocartilage), by Region - ... reach USD 779.8 Million by 2021 from USD 414.6 Million in ... of 2016 to 2021. Continue Reading ... ...
(Date:12/5/2016)... PUNE, India , December 5, 2016 According ... by Product Type and by Application - Global Opportunity Analysis and Industry Forecast, ... 2015, and is expected to reach $5,255 million by 2022, growing at a ... in 2015 with more than four-fifths share. Continue ... ...
(Date:12/5/2016)... and PUNE, India , December ... report by Allied Market Research, titled, "Global Cancer Biomarkers Market ... revenue of cancer biomarkers market is projected to reach $15,737 ... CAGR of 13.3% from 2016 to 2022. Omic technologies segment ... 2015 and is expected to maintain its dominance during the ...
Breaking Medicine Technology: