Navigation Links
Anti-osteoporosis Drugs Could Result in Irregular Heart Rhythm, New Study

Research has revealed some disturbing link between Reclast, made by Novartis AG and Fosamax manufactured by Merck and Co and irregular heart rhythm//, though only in a small number of women users. Both are known bone-building drugs.

The signs of a problem seem to be more pronounced with Reclast, given as an annual shot. But there was a hint of similar trouble in a few women who took the leading osteoporosis pill, Fosamax by Merck & Co. They are all at risk for a condition called atrial fibrillation, an irregular heart rhythm that can cause strokes.

Though it is still uncertain how big a worry it might be, experts agreed the overall risk is small. They said women at high risk for bone breaks _ the main target of these osteoporosis drugs _ should keep taking them as prescribed.

Two separate reports published Thursday in The New England Journal of Medicine point to elevated rates of serious episodes of that heart condition in women.

"For the first time, there may be a side effect," said a researcher involved in both studies, Dr. Steven Cummings of California Pacific Medical Center Research Institute. Until now, people have assumed Fosamax "was completely safe and could be given to almost anybody."

Fosamax, the Merck brand name for alendronate, is now used by an estimated 1.8 million American women. In a letter to the medical journal, Cummings reported evidence of the heart problem found in a recent review of a 1997 Merck-sponsored study of postmenopausal women on Fosamax.

There appeared to be 50 percent more risk of the serious heart rhythm in women who took the daily pill than among those who didn't take it. About half of the 6,459 women took Fosamax, and 47 developed atrial fibrillation, compared to just 31 cases among the other women.

However, the finding, while not statistically definitive for Fosamax, worried some researchers because it is in line with the results of a new study published in th e same issue of the medical journal.

This study of 7,736 postmenopausal women with bone-thinning osteoporosis focuses on Reclast. Novartis recently won approval to sell Reclast, known generically as zoledronic acid, for Paget's disease, another bone condition. The company hopes to get an OK later this year to sell it for osteoporosis use.

The new study, funded by Novartis, shows that Reclast works at least as well as existing drugs in the same class, researchers say. However, the risk of a serious case of irregular heart rhythm was more than double that in the other patients _ 50 cases in the drug-taking half, compared to 20 cases in the others.

Researchers cautioned about overestimating the importance of the heart rhythm problem. The Reclast study showed little apparent difference in overall cardiac deaths and the overall risk of the rhythm condition remained small.

Doctors made available by Merck and Novartis said the side effect could be a statistical fluke or just a product of aging. They said earlier studies showed no sign of the possible side effect.

For now, it's unknown if the possible risk applies to other drugs in the class known as biphosphonates. Future studies are expected to help clarify the risk.
SRM/B
'"/>




Related medicine news :

1. Vitamin D or Anti-osteoporosis Drug Reduces Bone Loss from Binge Drinking
2. Lean Protein Could Be Key to Obesity Drugs
3. Life Saving Cancer Drugs – From Chicken! Possible Says Dolly’ Creatos
4. Nasal Spray Could Take Drugs Direct to Brain.
5. Emphasis to ban Drugs ads by Doctors
6. Osteoporosis Drugs: right time to take-off
7. Drugs disrupt formation of blood vessels
8. Drugs to stop burgeon of HIV
9. Misleading Advertisements for Prescription Drugs
10. Drugs For Anthrax May Interfere With Oral Contraceptives
11. Over-The-Counter Drugs May Prevent Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... ... March 28, 2017 , ... Medforce Technologies, Inc., ... to announce it has joined the National Association for Home Care and Hospice ... ill, disabled, and dying Americans of all ages and the caregiver who provide ...
(Date:3/28/2017)... ... March 28, 2017 , ... Alert Sentry Group LLC., ... (Mobile Personal Emergency Response Systems), the iSAFE and the iSAFE Plus. These iSAFE products ... first of their kind, the iSAFE and iSAFE Plus offer direct GPS Location and ...
(Date:3/28/2017)... ... March 28, 2017 , ... Usually, the impending arrival ... wardrobe. However, for those self-conscious about a double chin, this means more anxiety than ... solution. , “For most people, a double chin is undesirable,” Dr. Goldman said, ...
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... ... leading physicians, Paul Yost, will begin serving as new board chair for Orange ... month. Yost will serve the remainder of soon-to-be former chair Mark Refowitz’s term, ...
(Date:3/28/2017)... ... , ... With less than 10,000 dermatologists in the United States and more ... while the desire to conquer breakouts and eliminate skincare stress is widespread. Curology ... today released its inaugural survey on the State of Acne in America. , ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... , March 28, 2017 The ... reach USD 8.0 billion by 2025, according to a ... incidence of infectious diseases and cancer is expected to ... disease diagnosis over the coming years. In addition, higher ... autologous and allogenic stem cell therapy, due to adverse ...
(Date:3/27/2017)... 27, 2017 Summary This ... Bayer and its partnering interests and activities since 2010. ... an in-depth insight into the partnering activity of one of ... company reports are prepared upon purchase to ensure inclusion of ... The report will be delivered in PDF format within ...
(Date:3/27/2017)... , March 27, 2017  ImMAGE Biotherapeutics (OTCMKTS: IMMG), ... successfully passed early toxicology and efficacy studies. The company ... target a specific protein, MAGE A, in an effort ... cancer. After 4 weeks of treatment ... show very little toxicity in a full toxicology report ...
Breaking Medicine Technology: