Navigation Links
Anti-inflammatory Drugs Interact With Hormone Replacement Therapy

Any cardio protective effect of hormone replacement therapy may be inhibited if women are taking a particular type of non-steroidal anti-inflammatory pain killer, report researchers led by Garret FitzGerald from University of Pennsylvania.

The researchers examined the medical records of 1,673 women aged between 50 and 84 years from the UKs General Practice Research Database who had heart attacks or who died from coronary heart disease and compared them with 7,005 control women. Current use of hormone replacement therapy was associated with a significantly lower risk of heart attack than non-use; with an odds ratio of 0.78.

However, in women who used traditional nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, which variably inhibit both cyclooxygenase (COX)-1 and COX-2, at the same time as hormone replacement therapy, the chance of heart attack among this group o f women, as compared to nonusers of these NSAIDs and hormone replacement therapy, was 1.5, which was not significantly different.

There is conflicting evidence from previous work about whether hormone replacement therapy protects against heart disease in women. In addition, any beneficial effect of hormone replacement therapy on the heart might be counteracted by NSAIDs which inhibit COX-2. Inhibition of COX-2 prevents production of prostacyclin, which has a role in preventing blood clotting. As estrogen acts to increase production of prostacyclin; it is possible that the effect of hormone replacement therapy on the heart is counteracted by these NSAIDs.

The authors conclude that these observations, based on small numbers, are provocative rather than conclusive and are not intended to guide clinical practice, but rather to prompt additional research. Ultimately determination of the clinical implications of these findings will need to be addressed in future trials.


'"/>




Page: 1

Related medicine news :

1. Anti-inflammatory drugs reduce the risk of oral cancer for smokers
2. Protein Secreted By Worm Eggs Holds Key To Anti-inflammatory Therapy
3. Anti-inflammatory Drug Fails to Improve COPD Symptoms
4. Anti-inflammatory Drug Fails to Improve COPD Symptoms
5. Lean Protein Could Be Key to Obesity Drugs
6. Life Saving Cancer Drugs – From Chicken! Possible Says Dolly’ Creatos
7. Nasal Spray Could Take Drugs Direct to Brain.
8. Emphasis to ban Drugs ads by Doctors
9. Osteoporosis Drugs: right time to take-off
10. Drugs disrupt formation of blood vessels
11. Drugs to stop burgeon of HIV
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... ... ... Asante, a nationally recognized health system in southern Oregon, ... health joint venture through an agreement, effective October 1, 2017, to create AccentCare ... company with Asante, delivering clinically integrated care, for the past eight years. This ...
(Date:10/12/2017)... ANGELES (PRWEB) , ... October 12, 2017 , ... ... Parsa Mohebi Hair Restoration, has recently contributed a medical article to the newly ... on cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as ...
(Date:10/12/2017)... ... , ... Leading pediatric oncology experts at Children’s National Health System ... of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by ... Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of the ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... named one of Michigan’s 2017 Best and Brightest in Wellness® by Best and ... Wellness® awards program on Friday, Oct. 20 from 7:30 a.m. to 2 p.m. ...
(Date:10/12/2017)... BALTIMORE (PRWEB) , ... October 12, 2017 , ... ... average of $3,296 in property taxes a year. In some states—like New York, ... higher. , By contrast, many overseas retirement havens have extremely low property-tax rates, ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Oct. 2, 2017 Halo Labs announces the European launch ... called the HORIZON at MIBio 2017 in Cambridge, U.K ... visible particulate matter in biopharmaceutical samples with unprecedented speed and sensitivity ... novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
(Date:9/28/2017)... Sept. 28, 2017 Cohen Veterans Bioscience and ... use of wearable and home sensors for real-time monitoring ... Signal Foundation, a nonprofit organization focused on disruptive health ... an affordable analytical system to record and integrate behavioral, ... ...
(Date:9/25/2017)... , Sept. 25, 2017   Montrium , ... File solutions, today—from the IQPC Trial Master Files ... , NL)—announced that EastHORN Clinical Services has selected ... programs and TMF management. EastHORN, a leading European ... platform to increase transparency to enable greater collaboration ...
Breaking Medicine Technology: