Navigation Links
Anti-inflammatory Drug Fails to Improve COPD Symptoms

-tumor necrosis factor TNF-, and a number of studies have reported increased production of TNF in COPD patients. This increased production has been linked to weight loss, muscle weakness and muscle loss.

In addition, animal studies supported the prospect using the drug in COPD. When TNF- was infused into rats, they developed emphysema, which, along with chronic bronchitis, makes up most COPD cases. When the TNF- receptor was turned off in mice, they were less likely than mice that had not be genetically altered to develop emphysema when exposed to chronic cigarette smoke.

The latest study, however, did confirm a recently reported pilot study that found no improvement among the 14 COPD patients given infliximab.

In attempting to explain the disappointing results, the study authors speculate that, despite infliximab's efficacy in treating other inflammatory diseases, it may not be effective in COPD because other mediators, in addition to TNF-, are necessary to cause COPD. They also concede that six months may simply be too short a time period to see improvement.

However, an increased number of malignancies observed in infliximab-treated subjects, the authors said, raised concern about the safety of this drug in lung patients. Although the malignancies may have been present when the patients enrolled in the study, "the possibility that infliximab contributed to the progession, and thus the diagnosis, of malignancies remains a serious concern."

This safety issue, coupled with the "resoundingly negative results," make in unlikely that a longer trial will be undertaken, according to the accompanying editorial.


'"/>




Page: 1 2

Related medicine news :

1. Anti-inflammatory drugs reduce the risk of oral cancer for smokers
2. Protein Secreted By Worm Eggs Holds Key To Anti-inflammatory Therapy
3. Anti-inflammatory Drug Fails to Improve COPD Symptoms
4. Anti-inflammatory Drugs Interact With Hormone Replacement Therapy
5. Alcoholism Drug Fails To Prevent Drinking Relapses
6. Tamiflu Fails To Save Two Lives
7. Himachal Pradesh Fails To Become Health Tourism Center
8. Budhias Medical Report Fails to Address Long Term Health Issues
9. "Daydreaming" Network Fails In Autism
10. 72-year-old Bachelor of Rajasthan Fails Class 10 Again!
11. Already Short Staffed And In Deficit NHS Fails To Supply Staff For IT Project
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Anti inflammatory Drug Fails Improve COPD Symptoms

(Date:9/22/2014)... a very familiar "lub-dub" pattern that speeds up or ... pattern itself isn,t as regular as you might think. ... vary even at a "constant" heart rateand that variability, ... Reduced heart rate variability (HRV) has been found to ... congestive heart failure and inflammation. For athletes, a drop ...
(Date:9/22/2014)... 22, 2014 WHO: LiveOps, Inc., ... customer service solutions. , WHAT: The 10th annual ... customer care for the connected consumer. Constant change ... offer new challenges and opportunities for customer experience ... identify best practices, network and learn from fellow ...
(Date:9/22/2014)... HealthDay Reporter MONDAY, Sept. ... child,s brain processes sounds might help identify the severity ... Observing children,s brainwaves may also allow identification of autism ... "The finding that the brain,s response to certain ... hugely promising," said senior researcher Sophie Molholm, an associate ...
(Date:9/22/2014)... CA (PRWEB) September 22, 2014 ... California for a three-day conference to discuss brain-related ... brain injury from concussions and neurodegenerative disorders. ... medical director affiliated with a Silverado memory care ... of dedicated expertise in memory care, hosts the ...
(Date:9/22/2014)... The report segments the global physiotherapy ... geography. The equipment segment accounted for a lion’s ... product. However, the accessories segment is expected to ... period, owing to the rising demand of physiotherapy ... segments are the fastest-growing segments in the physiotherapy ...
Breaking Medicine News(10 mins):Health News:Variability keeps the body in balance 2Health News:Variability keeps the body in balance 3Health News:Variability keeps the body in balance 4Health News:LiveOps To Lead Panel Discussion At Customer Response Summit Memphis 2Health News:Brainwaves May Help Gauge Autism Severity: Study 2Health News:Brainwaves May Help Gauge Autism Severity: Study 3Health News:Brainwaves May Help Gauge Autism Severity: Study 4Health News:Nation’s Leading Brain Health Experts Gather for Annual Silverado Medical Director Conference 2Health News:Nation’s Leading Brain Health Experts Gather for Annual Silverado Medical Director Conference 3Health News:6.8% CAGR for Physiotherapy Equipment Market Globally to 2019 Says a New Research Report Available at ReportsnReports.com 2Health News:6.8% CAGR for Physiotherapy Equipment Market Globally to 2019 Says a New Research Report Available at ReportsnReports.com 3Health News:6.8% CAGR for Physiotherapy Equipment Market Globally to 2019 Says a New Research Report Available at ReportsnReports.com 4Health News:6.8% CAGR for Physiotherapy Equipment Market Globally to 2019 Says a New Research Report Available at ReportsnReports.com 5
... 4 BasicPlus Health,Insurance of Roswell, Ga., announced ... Companion Global Healthcare Inc. of Columbia, S.C., to,include ... most popular,limited benefit health insurance plans., The ... and BasicPlus (for individuals) limited benefit plans have ...
... outlines major issues and best practices for handling fresh, produce that every ... ... to know., ATLANTA, June 4 Fresh produce safety ... public awareness and,industry concern. At its biennial meeting in San Antonio, Texas, ...
... American Society for Investigative Pathology (ASIP) is pleased ... Professor of Pathology and Microbiology-Immunology at Northwestern University ... Amgen Outstanding Investigative Award, a prestigious annual award ... Amgen. Dr. Engman presented his paper, "Pathogenesis ...
... used chlorinated pesticides on more than 100 days in ... to researchers from the National Institutes of Health (NIH). ... from a 20 percent to a 200 percent increase ... Institute of Environmental Health Sciences (NIEHS) and the National ...
... LARGO, Fla., June 4 Unilens Vision ... UVI), which develops,licenses, manufactures, distributes and markets ... program for all Unilens GP (Gas Permeable),products., ... Professional,s Specialty Contact Lens,Company", continues its tradition ...
... 4th International Forum on Disability Management Will be Held in Berlin ... from 22 ... employees,capacity for work following sickness and disablement? Experts from,throughout the world will ... is to be held at the Berlin,Congress Centre from 22 to 24 ...
Cached Medicine News:Health News:Insurance Company Includes Global Network Option in Limited Benefit Plans 2Health News:Insurance Company Includes Global Network Option in Limited Benefit Plans 3Health News:Chemstar Corporation Publishes New Insights on Fresh Produce Safety From CFP Workshop 2Health News:Long-term pesticide exposure may increase risk of diabetes 2Health News:Long-term pesticide exposure may increase risk of diabetes 3Health News:Unilens Vision Announces New Policies Aimed at Increasing Eye Care Professionals Profitability 2Health News:Retaining Employees' Capacity For Work Following Sickness 2
(Date:9/22/2014)... Sept. 22, 2014  Inovio Pharmaceuticals, Inc. (NASDAQ: ... initiated a phase I clinical trial in patients ... safety, tolerability, and immunogenicity of INO-3106. This immunotherapy ... most aerodigestive cancers. Aerodigestive cancers affect ... and parts of the esophagus and windpipe. The ...
(Date:9/22/2014)...  CorMedix Inc. (NYSE MKT: CRMD), a pharmaceutical ... for the prevention and treatment of cardiorenal and ... TUV-SUD and The Medicinal Evaluation Board of ... its request for a label expansion for Neutrolin, ... in July 2013 for use in the prevention ...
(Date:9/22/2014)... 2014  Seres Health, a clinical-stage therapeutics company developing ... today announced that it has been named by ... companies, designating it as one of the most promising ... "Amid a great deal of ain,t-it-cool science in microbiomics, ... to practical therapeutic development," says Damian Garde , ...
Breaking Medicine Technology:Inovio Pharmaceuticals Expands HPV Immunotherapy Development to Aerodigestive Cancers 2Inovio Pharmaceuticals Expands HPV Immunotherapy Development to Aerodigestive Cancers 3Inovio Pharmaceuticals Expands HPV Immunotherapy Development to Aerodigestive Cancers 4Neutrolin Label Expansion Approved for the European Union 2Neutrolin Label Expansion Approved for the European Union 3Seres Health Named a "Fierce 15" Biotech Company for 2014 2
... BALTIMORE, Feb. 4, 2011 Ameritox®, the nation,s ... to advance its industry leadership position by strengthening ... the past twelve months.  Through significant investments in ... capabilities, Ameritox has reached several milestones – including ...
... R.I., Feb. 4, 2011 MEDfx Corporation today announced ... among providers using a combination of the standards and ... CONNECT Gateway. MEDfx is participating in, and is a ... of the National Coordinator of Health IT.  The MEDfx ...
Cached Medicine Technology:Ameritox® Continues to Advance Industry Leadership 2Ameritox® Continues to Advance Industry Leadership 3Ameritox® Continues to Advance Industry Leadership 4MEDfx to Harmonize the Direct Project With CONNECT 2MEDfx to Harmonize the Direct Project With CONNECT 3
... a leading provider of immunofluorescence assays, with ... that includes kits for autoimmune diseases, infectious ... conjugates and components. Our Impact IFA Test ... substrates and kit sizes to choose from. ...
... Diagnostics is a leading provider of immunofluorescence ... test menu that includes kits for autoimmune ... as miscellaneous conjugates and components. Our Impact ... assortment of substrates and kit sizes to ...
... Inverness Medical Professional Diagnostics is a leading ... IFA and DFA test menu that includes ... STDs as well as miscellaneous conjugates and ... you a wide assortment of substrates and ...
... is a leading provider of immunofluorescence assays, ... menu that includes kits for autoimmune diseases, ... miscellaneous conjugates and components. Our Impact IFA ... of substrates and kit sizes to choose ...
Medicine Products: