Navigation Links
Anti-fungal Drug Block Angiogenesis

Angiogenesis is the process by which the cancer cells ensure that new blood vessels feed it with nutrition to keep them growing; it is now discovered// that this can be blocked by a drug commonly used to treat toenail fungus called itraconazole.

New Research at Johns Hopkins have discovered that in mice itraconazole reduced blood vessel growth by 67 percent compared to placebo. "We were surprised, to say the least, that itraconazole popped up as a potential blocker of angiogenesis," says Jun O. Liu, Ph.D., professor of pharmacology. "We couldn't have predicted that an antifungal drug would have such a role."

There has been a great surge towards discovering these types of drugs to help in treating cancers. The tissue like human umbilical cords is a rich source of blood vessels and cells from it have been used in research. There have been almost 2,400 existing drugs that have been tested on these cells.

Itraconazole is a well known antifungal drug and it works by blocking a key enzyme for making fungal cholesterol and thus making them brittle and split apart.

"The best outcome was to find an already approved drug that worked, and the fact that we did was very satisfying," says Liu, whose study has appeared online in ACS Chemical Biology.

Itraconazole apparently maybe blocking the same enzyme in blood vessels, but the researchers aren't sure if that's the reason blood vessels stop growing.

"Our screening test did show that cholesterol-lowering statins also appear to stop blood vessel growth," Liu says, "so there is likely some important connection between cholesterol and angiogenesis."

"Itraconazole can be taken orally for fungal infection, and therefore oral delivery may work for angiogenesis as well," Liu notes. /M

Page: 1

Related medicine news :

1. Anti-fungal drug - Griseofulvin may help treat cancer
2. Blocked viens block eye sight
3. Human Antibody That Can Block SARS
4. Treating Blocked Arteries In The Lower Limbs
5. Blocking Pain Found To Slow Down The Healing Process
6. Operating on a Beating Heart Yields Better Results For Blocked Heart Arteries
7. Improving The Survival Of Lung Cancer Patients By Blocking The Effects Of Estrogen
8. Aspirin For Treating Blocked Brain Arteries
9. Humans Found To Have The Ability To Block Unwanted Memories
10. Valporic Acid Blocks Latent HIV Replication
11. Scientists Discover Ways To Block Virus From Attacking Cells
Post Your Comments:

(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set ... drug or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, ... traumatic event. , Trauma sufferers tend to feel a range of emotions, from depression, ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association ... it will receive two significant new grants to support its work to advance ... 25th anniversary by recognizing patients, medical professionals and scientists for their work in ...
(Date:6/24/2016)... ... 2016 , ... Comfort Keepers® of San Diego, CA is excited to announce ... program to drive cancer patients to and from their cancer treatments. Comfort Keepers ... of life and ongoing independence. Getting to and from medical treatments is one ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Research and Markets has announced the addition ... to their offering. The ... commercial environment for MedImmune to enter. The US ageing population ... to drive considerable growth for effective anti-influenza medications. The introduction ... considerably, but development is still in its infancy. ...
(Date:6/23/2016)... and INDIANAPOLIS , June 23, 2016 ... Lilly Diabetes Tomorrow,s Leaders Scholarship is any indication, the ... announced today online at by the ... diabetes stand in the way of academic and community ... Foundation,s scholarship program since 2012, and continues to advocate ...
(Date:6/23/2016)...  Guerbet announced today that it has been named ... . One of 12 suppliers to receive ... support of Premier members through exceptional local customer service ... to lower costs. ... outstanding customer service from Premier," says Massimo Carrara ...
Breaking Medicine Technology: