Navigation Links
Anti-fungal Drug Block Angiogenesis

Angiogenesis is the process by which the cancer cells ensure that new blood vessels feed it with nutrition to keep them growing; it is now discovered// that this can be blocked by a drug commonly used to treat toenail fungus called itraconazole.

New Research at Johns Hopkins have discovered that in mice itraconazole reduced blood vessel growth by 67 percent compared to placebo. "We were surprised, to say the least, that itraconazole popped up as a potential blocker of angiogenesis," says Jun O. Liu, Ph.D., professor of pharmacology. "We couldn't have predicted that an antifungal drug would have such a role."

There has been a great surge towards discovering these types of drugs to help in treating cancers. The tissue like human umbilical cords is a rich source of blood vessels and cells from it have been used in research. There have been almost 2,400 existing drugs that have been tested on these cells.

Itraconazole is a well known antifungal drug and it works by blocking a key enzyme for making fungal cholesterol and thus making them brittle and split apart.

"The best outcome was to find an already approved drug that worked, and the fact that we did was very satisfying," says Liu, whose study has appeared online in ACS Chemical Biology.

Itraconazole apparently maybe blocking the same enzyme in blood vessels, but the researchers aren't sure if that's the reason blood vessels stop growing.

"Our screening test did show that cholesterol-lowering statins also appear to stop blood vessel growth," Liu says, "so there is likely some important connection between cholesterol and angiogenesis."

"Itraconazole can be taken orally for fungal infection, and therefore oral delivery may work for angiogenesis as well," Liu notes. /M
'"/>




Page: 1

Related medicine news :

1. Anti-fungal drug - Griseofulvin may help treat cancer
2. Blocked viens block eye sight
3. Human Antibody That Can Block SARS
4. Treating Blocked Arteries In The Lower Limbs
5. Blocking Pain Found To Slow Down The Healing Process
6. Operating on a Beating Heart Yields Better Results For Blocked Heart Arteries
7. Improving The Survival Of Lung Cancer Patients By Blocking The Effects Of Estrogen
8. Aspirin For Treating Blocked Brain Arteries
9. Humans Found To Have The Ability To Block Unwanted Memories
10. Valporic Acid Blocks Latent HIV Replication
11. Scientists Discover Ways To Block Virus From Attacking Cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Anti fungal Drug Block Angiogenesis

(Date:12/20/2014)... Recently, AngelWeddingDress.com has introduced its special offer ... coming Christmas. In the promotion, all buyers worldwide can ... have something special for the women who are looking ... our new collections of 2015 dresses have been unveiled ... greatly discounted prices. Visit our website now before they ...
(Date:12/20/2014)... December 20, 2014 The Twin Cities ... education event in the nation! Over 250 financial professionals ... minute information on the industry, get motivated to protect ... real people facing and overcoming the challenges of disability. ... across the nation came together to attend The 13th ...
(Date:12/19/2014)... Balfleet.com , a leading dress company of wedding ... All the old and new customers can get a ... well-known for its high quality trendy women’s dresses, like ... more. Its formal dresses are quality made and come ... an elegant look when paired with any accessory. ...
(Date:12/19/2014)... 2014 Sub Zero Ice Cream is partnering ... drive Sunday the 28th from 2pm-6pm at the Expo Center ... in Sarasota, FL. , Inquiries regarding time slots and signing ... in the donating process, Sub Zero Ice Cream & Yogurt ... ice cream. , About Sub Zero Ice Cream & Yogurt ...
(Date:12/19/2014)... Missouri (PRWEB) December 19, 2014 Silver ... new official world record -- for the first time ever, ... prestigious record book, Guinness World Records 2015, listing the park’s ... Wooden Roller Coaster. In additional awards announced this week, Silver ... See Christmas Lights in the US,” USA Today’s 10Best awards ...
Breaking Medicine News(10 mins):Health News:AngelWeddingDress Has Introduced Its Special Offer For The Coming Christmas 2Health News:The 13th Annual Twin Cities DI Day Now On Video 2Health News:The 13th Annual Twin Cities DI Day Now On Video 3Health News:Balfleet.com Announces Its Formal Dress Promotion For 2015 2Health News:Shark Tank’s Sub Zero Ice Cream Sponsors Blood Drive 2Health News:Silver Dollar City Nets New Titles: Guinness Book of World Records, Plus CNN Travel, USA Today & Fodor’s Top Places for Christmas Lights 2
... 2011 -- Over 10 million people age 12 or older ... drugs in the prior year, according to a 2009 National ... most commonly detected non-alcohol drug in drivers, its role in ... between marijuana use by drivers and risk of a car ...
... -- New research suggests certain long-term psychotherapies may do ... stress disorder (PTSD) following a traumatic event. The ... PTSD didn,t seem to boost a person,s risk of ... when early clinical interventions cannot be provided," as might ...
... sinusitis is presented in a new thesis from Lund University. The ... the costs of the disease to society. Sinusitis is ... a chronic form. In Europe, over nine per cent of the ... thesis is Pernilla Sahlstrand Johnson, a PhD student and ear, nose ...
... , THURSDAY, Oct. 6 (HealthDay News) -- Technology that ... patients who were severely sickened by the H1N1 flu virus, ... their study had limitations, and they noted that debate continues ... At issue is a treatment called extracorporeal membrane oxygenation, which ...
... 6 (HealthDay News) -- People whose parents had a drinking ... they,re under stress, a new study says. Swedish researchers ... they had a family history of alcohol abuse. Both groups ... timed conditions in public) and then allowed to drink. ...
... HealthDay Reporter , THURSDAY, Oct. 6 (HealthDay ... children treated in emergency rooms for traumatic brain injuries, ... report from the U.S. Centers for Disease Control and ... saw 248,418 children with traumatic brain injuries compared to ...
Cached Medicine News:Health News:Marijuana use may double the risk of accidents for drivers 2Health News:Researchers Assess What Works Best to Prevent PTSD 2Health News:New method to diagnose sinusitis could reduce use of antibiotics 2Health News:Oxygenating Blood of Hospitalized H1N1 Flu Patients Saved Lives: Study 2Health News:More Kids Treated for Concussions in ERs: CDC 2Health News:More Kids Treated for Concussions in ERs: CDC 3
(Date:12/19/2014)... Dec. 19, 2014   Hospira, Inc. (NYSE: ... injectable drugs and infusion technologies, today announced that the ... Healthcare Conference on Wednesday, Jan. 14, 2015, in ... to begin at 10:30 a.m. Pacific time on Wednesday, ... interested parties through a live audiocast accessible via the ...
(Date:12/19/2014)...  Monarch America Inc. (OTCQB: CANK) ("Monarch America" or ... provide this review of the Company,s recent achievements and ... "Over this past year, we achieved many of our ... to say that Monarch America is in a stronger ... been," stated Eric Hagen , CEO of Monarch ...
(Date:12/19/2014)... YORK , Dec. 18, 2014 Somewhere ... addressing hearing health was forgotten. But Audicus , ... to hear better this new year. Hearing ... facing the aging population, though it is often unaddressed. ... in four has a hearing aid, mainly due to ...
Breaking Medicine Technology:Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 3Audicus Will Help People Resolve to Hear Better in 2015 2
... 8 Varian Medical Systems (NYSE: VAR ) ... of fiscal year 2010 following the close of regular trading ... followed by a teleconference available to all interested parties at ... the conference call webcast will be available on the company ...
... growing number of healthcare providers are choosing the ... control over non-file, off-contract spending, focusing on high-cost ... healthcare decision-makers receive sound content, accurate contract price ... rather than after the fact. With greater contract ...
Cached Medicine Technology:Varian Medical Systems Schedules Fourth Quarter FY2010 News Release and Conference Call 2Healthcare Providers Gain Control of Demand Channels With GHX Procurement Suite; 12 Percent Supply Spend Savings Achievable 2Healthcare Providers Gain Control of Demand Channels With GHX Procurement Suite; 12 Percent Supply Spend Savings Achievable 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: