Navigation Links
Anti-fungal Drug Block Angiogenesis

Angiogenesis is the process by which the cancer cells ensure that new blood vessels feed it with nutrition to keep them growing; it is now discovered// that this can be blocked by a drug commonly used to treat toenail fungus called itraconazole.

New Research at Johns Hopkins have discovered that in mice itraconazole reduced blood vessel growth by 67 percent compared to placebo. "We were surprised, to say the least, that itraconazole popped up as a potential blocker of angiogenesis," says Jun O. Liu, Ph.D., professor of pharmacology. "We couldn't have predicted that an antifungal drug would have such a role."

There has been a great surge towards discovering these types of drugs to help in treating cancers. The tissue like human umbilical cords is a rich source of blood vessels and cells from it have been used in research. There have been almost 2,400 existing drugs that have been tested on these cells.

Itraconazole is a well known antifungal drug and it works by blocking a key enzyme for making fungal cholesterol and thus making them brittle and split apart.

"The best outcome was to find an already approved drug that worked, and the fact that we did was very satisfying," says Liu, whose study has appeared online in ACS Chemical Biology.

Itraconazole apparently maybe blocking the same enzyme in blood vessels, but the researchers aren't sure if that's the reason blood vessels stop growing.

"Our screening test did show that cholesterol-lowering statins also appear to stop blood vessel growth," Liu says, "so there is likely some important connection between cholesterol and angiogenesis."

"Itraconazole can be taken orally for fungal infection, and therefore oral delivery may work for angiogenesis as well," Liu notes. /M
'"/>




Page: 1

Related medicine news :

1. Anti-fungal drug - Griseofulvin may help treat cancer
2. Blocked viens block eye sight
3. Human Antibody That Can Block SARS
4. Treating Blocked Arteries In The Lower Limbs
5. Blocking Pain Found To Slow Down The Healing Process
6. Operating on a Beating Heart Yields Better Results For Blocked Heart Arteries
7. Improving The Survival Of Lung Cancer Patients By Blocking The Effects Of Estrogen
8. Aspirin For Treating Blocked Brain Arteries
9. Humans Found To Have The Ability To Block Unwanted Memories
10. Valporic Acid Blocks Latent HIV Replication
11. Scientists Discover Ways To Block Virus From Attacking Cells
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/8/2016)... Somerset, N.J. (PRWEB) , ... December 08, 2016 ... ... advanced delivery technologies and development solutions for drugs, biologics and consumer health products, ... The PSCI was set up in 2006 as a non-profit organization to unite ...
(Date:12/8/2016)... ... December 08, 2016 , ... Today’s patients are ... this in mind, SIGVARIS has created a new line of anti-embolism stockings to ... and provide the benefits of graduated compression when transitioning from recovery to early ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... services from offices headquartered in Hamilton County, is embarking on a charity drive ... specializes in finding new homes for orphaned or neglected senior dogs in the ...
(Date:12/8/2016)... ... December 08, 2016 , ... The Compretta Insurance Agency, a family owned ... and around the Hancock County area, is announcing the launch of a charity effort ... The Hancock County Food Pantry has worked for more than 30 years to meet ...
(Date:12/7/2016)... ... , ... Students attending Envision’s summer 2017 National Youth ... experience in an emergency medical simulation, When Care is Hours Away. This dynamic ... skills that are critical success in a future career and beyond. , The ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... DUBLIN , Dec 8, 2016 Research ... Electrodes Market Analysis and Trends - Adhesion Type, Application, Usability - ... ... The Global Cardiology Electrodes Market is poised to grow at a ... prominent trends that the market is witnessing include advancements in extracellular ...
(Date:12/8/2016)...  Pennsylvania Physician General Dr. Rachel Levine ... Gary Tennis released safe prescribing guidelines ... developed with the help of a task force. ... frequently prescribed for anxiety or insomnia," said Dr. ... pain medications, benzodiazepines pose a significant risk for ...
(Date:12/8/2016)... , Dec. 8, 2016  EIP Pharma, LLC ... obtained proof-of-mechanism for neflamapimod (previously code named VX-745), ... 2a clinical trials that demonstrated significant Alzheimer,s disease ... (12-week treatment) and Study 303 (6-week treatment) are ... in Alzheimer,s Disease (CTAD) scientific conference in ...
Breaking Medicine Technology: