Navigation Links
Anti-Parasitic Drugs Useful in Reducing Damages of Congenital Toxoplasmosis

Recent studies of long-term clinical data has revealed that treatment with pyrimethamine and sulfadiazine (two anti-parasitic drugs) during the first year of life// leads to a lasting reduction in brain and eye damage for children with congenital toxoplasmosis.

In the May 15 issue of the journal Clinical Infectious Disease, researchers report that a treatment they defined -- now considered the standard of care because it improves early outcomes -- resulted in normal longer-term neurologic outcomes for all patients born with the infection who did not already have severe brain involvement.

Even for many patients born with moderate or severe neurologic disease, the treatment was able to resolve symptoms within a few weeks. Seventy-two percent of those patients had normal long-term cognitive outcomes.

By demonstrating the benefits of diagnosing and treating the infection, these findings have renewed the call for comprehensive screening for this acute parasitic infection in pregnant women and newborns.

‘We now know that we can improve longer-term outcomes if we treat the acute infection early,’ said study author Rima McLeod, M.D., professor of infectious diseases and medical director of the Toxoplasmosis Center at the University of Chicago, ‘but to treat it early we have to detect it early and we know we are missing many infants who would benefit.’

According to the Centers for Disease Control and Prevention, approximately 85 percent of women of childbearing age in the United States are at risk of acquiring the infection for the first time during gestation and transmitting the infection to their fetus. The Toxoplasma gondii parasite infects humans through undercooked, infected meat; through T. gondii oocysts found in cat litter; or when a newly infected pregnant woman transmits the parasite to her fetus.

Most people have no recognized symptoms. The immune system usually keeps the parasite from causing acute illn ess. If the infection is acquired for the first time while a woman is pregnant, however, it can cause serious problems for the fetus, including severe eye and brain damage.

The National Collaborative Chicago-Based Congenital Toxoplasmosis Study followed 120 infants from the United States and Canada who had been diagnosed with toxoplasmosis soon after birth and were referred, between 1981 and 2004, for treatment and periodic evaluation by the study team. Eighty percent of these infants (96/120) had clinical abnormalities at birth, often severe.

Patients were treated with pyrimethamine at one of two different dose levels and sulfadiazine for one year and then followed periodically. Follow-up evaluations assessed neurologic status, including movement abnormalities and cognitive function, vision, including the development of new lesions in the eye, and hearing loss.

The authors emphasize that the median age of these children is about 10 years and longer follow up into adulthood is needed to determine whether these current favorable outcomes are sustained.

Almost all of the outcomes were markedly better than the previously reported outcomes for children who were either untreated or treated for only one month, which was the usual approach at the beginning of the study.

Of the 96 children in this study who had severe disease at birth, 47 have been in the study for at least 7.5 years. Eighty percent of the children with severe disease now have normal motor function; 73 percent have IQs greater than 70; 84 percent have had no decrease in IQ of 15 points between evaluations. (Such a decrease is a sign of a progressing infection.)

Although most of these patients had eye disease at the beginning of the study and 85 percent have some impairment of vision, 64 percent have had no new retinal lesions since beginning treatment.

Unfortunately 11 of the 96 severely affected infants died, nine of them from respirator y infections associated with their disability. None of the deaths were related to treatment.

Of the 24 children who had no, mild or moderate symptoms at birth, 11 have already reached the age of 7.5 years. All 24 have normal motor and cognitive function and hearing. One child older than 7.5 years had a 15-point IQ decrease between evaluations. One developed a new retinal lesion.

‘The majority of the children in our cohort are entering adolescence without experiencing recurrent eye lesions or seizures and with normal cognitive and motor function,’ the authors wrote. This congenital infection, they added, is ‘preventable and treatable.’

‘Prior studies had shown that untreated children or children who received a short course of therapy (1 month) did poorly,’ noted Kami Kim, M.D., professor of infectious diseases and medicine at Albert Einstein College of Medicine, in a commentary in the journal. In this present study, ‘children with severe disease had a remarkably better outcome.’

This promising result provides ‘compelling evidence’ for prolonged treatment, she said. Because such treatment improves outcome, ‘it may be time to consider a more comprehensive plan for neonatal screening for congenital toxoplasmosis.’

More than one year ago, the research team recommended systematic toxoplasmosis screening for all pregnant women in the United States during prenatal visits, as well as screening for congenital toxoplasmosis in all newborns.

Most states already require screening of newborns for a number of genetic and metabolic diseases that are less common than toxoplasmosis, but there is no systematic program for screening for toxoplasmosis during pregnancy in the United States. The Genetics Newborn Screening Advisory Group noted that the rationale for screening for toxoplasmosis was as compelling as the rationale for detection of genetic diseases for which screening is now mandated in many states.

Source Eurekalert
'"/>




Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Life Saving Cancer Drugs – From Chicken! Possible Says Dolly’ Creatos
3. Nasal Spray Could Take Drugs Direct to Brain.
4. Emphasis to ban Drugs ads by Doctors
5. Osteoporosis Drugs: right time to take-off
6. Drugs disrupt formation of blood vessels
7. Drugs to stop burgeon of HIV
8. Misleading Advertisements for Prescription Drugs
9. Drugs For Anthrax May Interfere With Oral Contraceptives
10. Over-The-Counter Drugs May Prevent Alzheimers
11. Steps To Improve Quality Of Plant-Based Drugs
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2017)... ... May 26, 2017 , ... Water damage to the flooring of several ... had left education officials with a number of critical issues to address before students ... to be accomplished with little or no disruption to class schedules. Second, the project ...
(Date:5/24/2017)... ... 24, 2017 , ... In modern research, success depends greatly ... for research and understanding the basic principles that were designed to drive that ... in stereo microscopy for brightfield and fluorescence typically used in laboratories working on ...
(Date:5/24/2017)... (PRWEB) , ... May 24, 2017 , ... Altec ... its participation in nVerge 2017 – a one-day technology conference in San Diego, CA. ... management solution, which allows users to fully utilize and enhance their Sage ERP solutions ...
(Date:5/24/2017)... ... May 24, 2017 , ... Drs. Nicholas Rallis and ... now spent 10 years as clinical instructors for the reputable Full Mouth Rehabilitation ... Through the program, private practitioners receive cutting-edge clinical training and learn how to ...
(Date:5/24/2017)... OH (PRWEB) , ... May 24, 2017 , ... Patients ... in Cortland, OH, can now meet with Dr. Joseph Bedich for a consultation, with ... while simultaneously improving their oral health and functionality. , Dr. Bedich offers ...
Breaking Medicine News(10 mins):
(Date:5/12/2017)...  The China and Canada joint tech ... water, energy and detergent, and features a powerful disinfection process. ... washing machine that washes and sanitizes women,s panties or babies, cloth ... ... does not require an external water inlet. ...
(Date:5/10/2017)... Mass., May 10, 2017 Hologic, Inc. (Nasdaq: ... results for the fiscal second quarter ended April 1, ... of $1.84 increased 666.7% compared to the prior year ... resulted in a significant gain, while non-GAAP diluted EPS ... 3.2%, or 3.8% in constant currency terms.  Excluding the ...
(Date:5/10/2017)... , May 10, 2017  The Corporate ... or employees of sleep therapy clinics to call ... sleep therapy clinic is involved in a substantial ... interested in hearing from an employee of a ... in a kickback scheme to provide medical practice groups ...
Breaking Medicine Technology: